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Beneficial Effects of the Consumption of Hot-Water Extracts of Thinned Immature Mangos (Mangifera indica “Irwin”) on the Hypertriglyceridemia of Apolipoprotein E-Deficient Mice

The thinned immature fruit of the mango tree (Mangifera indica “Irwin”) are regarded as waste products. In this study, we evaluated the effects of daily consumption of a hot-water extract of thinned immature mango fruits (TIMEx) on the dyslipidemia of apolipoprotein E-deficient (ApoE(−/−)) mice. Apo...

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Autores principales: Tajiri, Hayato, Tanaka, Wataru, Matsuyama, Hiroki, Sugita, Takuya, Hidaka, Kenta, Yokoyama, Daigo, Sakakibara, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876935/
https://www.ncbi.nlm.nih.gov/pubmed/35208189
http://dx.doi.org/10.3390/metabo12020116
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author Tajiri, Hayato
Tanaka, Wataru
Matsuyama, Hiroki
Sugita, Takuya
Hidaka, Kenta
Yokoyama, Daigo
Sakakibara, Hiroyuki
author_facet Tajiri, Hayato
Tanaka, Wataru
Matsuyama, Hiroki
Sugita, Takuya
Hidaka, Kenta
Yokoyama, Daigo
Sakakibara, Hiroyuki
author_sort Tajiri, Hayato
collection PubMed
description The thinned immature fruit of the mango tree (Mangifera indica “Irwin”) are regarded as waste products. In this study, we evaluated the effects of daily consumption of a hot-water extract of thinned immature mango fruits (TIMEx) on the dyslipidemia of apolipoprotein E-deficient (ApoE(−/−)) mice. ApoE(−/−) mice and wild-type BALB/c mice were fed a 20% fat diet containing 0%, 0.1%, or 1.0% TIMEx for 8 weeks. Their body mass, food intake, and water consumption were unaffected by the TIMEx. The 1.0% TIMEx supplementation significantly reduced serum triglyceride, but not total cholesterol concentration. This effect was significant in ApoE(−/−) mice, but less marked under normal conditions in wild-type mice. In addition, the circulating concentrations of three hormones that regulate metabolism, resistin, leptin, and glucose-dependent insulinotropic polypeptide, were reduced by TIMEx consumption, which may be involved in its effect to prevent hypertriglyceridemia. However, none of the concentrations of TIMEx reduced the size of atherosclerotic plaque lesions. In conclusion, daily consumption of TIMEx ameliorates hypertriglyceridemia but not hypercholesterolemia in genetically predisposed mice.
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spelling pubmed-88769352022-02-26 Beneficial Effects of the Consumption of Hot-Water Extracts of Thinned Immature Mangos (Mangifera indica “Irwin”) on the Hypertriglyceridemia of Apolipoprotein E-Deficient Mice Tajiri, Hayato Tanaka, Wataru Matsuyama, Hiroki Sugita, Takuya Hidaka, Kenta Yokoyama, Daigo Sakakibara, Hiroyuki Metabolites Article The thinned immature fruit of the mango tree (Mangifera indica “Irwin”) are regarded as waste products. In this study, we evaluated the effects of daily consumption of a hot-water extract of thinned immature mango fruits (TIMEx) on the dyslipidemia of apolipoprotein E-deficient (ApoE(−/−)) mice. ApoE(−/−) mice and wild-type BALB/c mice were fed a 20% fat diet containing 0%, 0.1%, or 1.0% TIMEx for 8 weeks. Their body mass, food intake, and water consumption were unaffected by the TIMEx. The 1.0% TIMEx supplementation significantly reduced serum triglyceride, but not total cholesterol concentration. This effect was significant in ApoE(−/−) mice, but less marked under normal conditions in wild-type mice. In addition, the circulating concentrations of three hormones that regulate metabolism, resistin, leptin, and glucose-dependent insulinotropic polypeptide, were reduced by TIMEx consumption, which may be involved in its effect to prevent hypertriglyceridemia. However, none of the concentrations of TIMEx reduced the size of atherosclerotic plaque lesions. In conclusion, daily consumption of TIMEx ameliorates hypertriglyceridemia but not hypercholesterolemia in genetically predisposed mice. MDPI 2022-01-25 /pmc/articles/PMC8876935/ /pubmed/35208189 http://dx.doi.org/10.3390/metabo12020116 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tajiri, Hayato
Tanaka, Wataru
Matsuyama, Hiroki
Sugita, Takuya
Hidaka, Kenta
Yokoyama, Daigo
Sakakibara, Hiroyuki
Beneficial Effects of the Consumption of Hot-Water Extracts of Thinned Immature Mangos (Mangifera indica “Irwin”) on the Hypertriglyceridemia of Apolipoprotein E-Deficient Mice
title Beneficial Effects of the Consumption of Hot-Water Extracts of Thinned Immature Mangos (Mangifera indica “Irwin”) on the Hypertriglyceridemia of Apolipoprotein E-Deficient Mice
title_full Beneficial Effects of the Consumption of Hot-Water Extracts of Thinned Immature Mangos (Mangifera indica “Irwin”) on the Hypertriglyceridemia of Apolipoprotein E-Deficient Mice
title_fullStr Beneficial Effects of the Consumption of Hot-Water Extracts of Thinned Immature Mangos (Mangifera indica “Irwin”) on the Hypertriglyceridemia of Apolipoprotein E-Deficient Mice
title_full_unstemmed Beneficial Effects of the Consumption of Hot-Water Extracts of Thinned Immature Mangos (Mangifera indica “Irwin”) on the Hypertriglyceridemia of Apolipoprotein E-Deficient Mice
title_short Beneficial Effects of the Consumption of Hot-Water Extracts of Thinned Immature Mangos (Mangifera indica “Irwin”) on the Hypertriglyceridemia of Apolipoprotein E-Deficient Mice
title_sort beneficial effects of the consumption of hot-water extracts of thinned immature mangos (mangifera indica “irwin”) on the hypertriglyceridemia of apolipoprotein e-deficient mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876935/
https://www.ncbi.nlm.nih.gov/pubmed/35208189
http://dx.doi.org/10.3390/metabo12020116
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