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New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis
Osteoporosis (OP) is a systemic bone disease characterized by decreased bone strength, microarchitectural changes in bone tissues, and increased risk of fracture. Its occurrence is closely related to various factors such as aging, genetic factors, living habits, and nutritional deficiencies as well...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876989/ https://www.ncbi.nlm.nih.gov/pubmed/35216140 http://dx.doi.org/10.3390/ijms23042020 |
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author | Che, Yanting Yang, Jingzhi Tang, Fen Wei, Ziheng Chao, Yufan Li, Na Li, Henghui Wu, Si Dong, Xin |
author_facet | Che, Yanting Yang, Jingzhi Tang, Fen Wei, Ziheng Chao, Yufan Li, Na Li, Henghui Wu, Si Dong, Xin |
author_sort | Che, Yanting |
collection | PubMed |
description | Osteoporosis (OP) is a systemic bone disease characterized by decreased bone strength, microarchitectural changes in bone tissues, and increased risk of fracture. Its occurrence is closely related to various factors such as aging, genetic factors, living habits, and nutritional deficiencies as well as the disturbance of bone homeostasis. The dysregulation of bone metabolism is regarded as one of the key influencing factors causing OP. Cholesterol oxidation products (COPs) are important compounds in the maintenance of bone metabolic homeostasis by participating in several important biological processes such as the differentiation of mesenchymal stem cells, bone formation in osteoblasts, and bone resorption in osteoclasts. The effects of specific COPs on mesenchymal stem cells are mainly manifested by promoting osteoblast genesis and inhibiting adipocyte genesis. This review aims to elucidate the biological roles of COPs in OP development, starting from the molecular mechanisms of OP, pointing out opportunities and challenges in current research, and providing new ideas and perspectives for further studies of OP pathogenesis. |
format | Online Article Text |
id | pubmed-8876989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88769892022-02-26 New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis Che, Yanting Yang, Jingzhi Tang, Fen Wei, Ziheng Chao, Yufan Li, Na Li, Henghui Wu, Si Dong, Xin Int J Mol Sci Review Osteoporosis (OP) is a systemic bone disease characterized by decreased bone strength, microarchitectural changes in bone tissues, and increased risk of fracture. Its occurrence is closely related to various factors such as aging, genetic factors, living habits, and nutritional deficiencies as well as the disturbance of bone homeostasis. The dysregulation of bone metabolism is regarded as one of the key influencing factors causing OP. Cholesterol oxidation products (COPs) are important compounds in the maintenance of bone metabolic homeostasis by participating in several important biological processes such as the differentiation of mesenchymal stem cells, bone formation in osteoblasts, and bone resorption in osteoclasts. The effects of specific COPs on mesenchymal stem cells are mainly manifested by promoting osteoblast genesis and inhibiting adipocyte genesis. This review aims to elucidate the biological roles of COPs in OP development, starting from the molecular mechanisms of OP, pointing out opportunities and challenges in current research, and providing new ideas and perspectives for further studies of OP pathogenesis. MDPI 2022-02-11 /pmc/articles/PMC8876989/ /pubmed/35216140 http://dx.doi.org/10.3390/ijms23042020 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Che, Yanting Yang, Jingzhi Tang, Fen Wei, Ziheng Chao, Yufan Li, Na Li, Henghui Wu, Si Dong, Xin New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis |
title | New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis |
title_full | New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis |
title_fullStr | New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis |
title_full_unstemmed | New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis |
title_short | New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis |
title_sort | new function of cholesterol oxidation products involved in osteoporosis pathogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876989/ https://www.ncbi.nlm.nih.gov/pubmed/35216140 http://dx.doi.org/10.3390/ijms23042020 |
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