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New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis

Osteoporosis (OP) is a systemic bone disease characterized by decreased bone strength, microarchitectural changes in bone tissues, and increased risk of fracture. Its occurrence is closely related to various factors such as aging, genetic factors, living habits, and nutritional deficiencies as well...

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Detalles Bibliográficos
Autores principales: Che, Yanting, Yang, Jingzhi, Tang, Fen, Wei, Ziheng, Chao, Yufan, Li, Na, Li, Henghui, Wu, Si, Dong, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876989/
https://www.ncbi.nlm.nih.gov/pubmed/35216140
http://dx.doi.org/10.3390/ijms23042020
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author Che, Yanting
Yang, Jingzhi
Tang, Fen
Wei, Ziheng
Chao, Yufan
Li, Na
Li, Henghui
Wu, Si
Dong, Xin
author_facet Che, Yanting
Yang, Jingzhi
Tang, Fen
Wei, Ziheng
Chao, Yufan
Li, Na
Li, Henghui
Wu, Si
Dong, Xin
author_sort Che, Yanting
collection PubMed
description Osteoporosis (OP) is a systemic bone disease characterized by decreased bone strength, microarchitectural changes in bone tissues, and increased risk of fracture. Its occurrence is closely related to various factors such as aging, genetic factors, living habits, and nutritional deficiencies as well as the disturbance of bone homeostasis. The dysregulation of bone metabolism is regarded as one of the key influencing factors causing OP. Cholesterol oxidation products (COPs) are important compounds in the maintenance of bone metabolic homeostasis by participating in several important biological processes such as the differentiation of mesenchymal stem cells, bone formation in osteoblasts, and bone resorption in osteoclasts. The effects of specific COPs on mesenchymal stem cells are mainly manifested by promoting osteoblast genesis and inhibiting adipocyte genesis. This review aims to elucidate the biological roles of COPs in OP development, starting from the molecular mechanisms of OP, pointing out opportunities and challenges in current research, and providing new ideas and perspectives for further studies of OP pathogenesis.
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spelling pubmed-88769892022-02-26 New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis Che, Yanting Yang, Jingzhi Tang, Fen Wei, Ziheng Chao, Yufan Li, Na Li, Henghui Wu, Si Dong, Xin Int J Mol Sci Review Osteoporosis (OP) is a systemic bone disease characterized by decreased bone strength, microarchitectural changes in bone tissues, and increased risk of fracture. Its occurrence is closely related to various factors such as aging, genetic factors, living habits, and nutritional deficiencies as well as the disturbance of bone homeostasis. The dysregulation of bone metabolism is regarded as one of the key influencing factors causing OP. Cholesterol oxidation products (COPs) are important compounds in the maintenance of bone metabolic homeostasis by participating in several important biological processes such as the differentiation of mesenchymal stem cells, bone formation in osteoblasts, and bone resorption in osteoclasts. The effects of specific COPs on mesenchymal stem cells are mainly manifested by promoting osteoblast genesis and inhibiting adipocyte genesis. This review aims to elucidate the biological roles of COPs in OP development, starting from the molecular mechanisms of OP, pointing out opportunities and challenges in current research, and providing new ideas and perspectives for further studies of OP pathogenesis. MDPI 2022-02-11 /pmc/articles/PMC8876989/ /pubmed/35216140 http://dx.doi.org/10.3390/ijms23042020 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Che, Yanting
Yang, Jingzhi
Tang, Fen
Wei, Ziheng
Chao, Yufan
Li, Na
Li, Henghui
Wu, Si
Dong, Xin
New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis
title New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis
title_full New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis
title_fullStr New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis
title_full_unstemmed New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis
title_short New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis
title_sort new function of cholesterol oxidation products involved in osteoporosis pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876989/
https://www.ncbi.nlm.nih.gov/pubmed/35216140
http://dx.doi.org/10.3390/ijms23042020
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