The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography

The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound’s state during wound healing including the effect of low-dose photodynamic therapy using topical app...

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Detalles Bibliográficos
Autores principales: Zuhayri, Hala, Nikolaev, Viktor V., Lepekhina, Tatiana B., Sandykova, Ekaterina A., Krivova, Natalya A., Kistenev, Yury V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877015/
https://www.ncbi.nlm.nih.gov/pubmed/35214134
http://dx.doi.org/10.3390/pharmaceutics14020399
Descripción
Sumario:The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound’s state during wound healing including the effect of low-dose photodynamic therapy using topical application of two different photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser doses of 1 J/cm(2) and 4 J/cm(2). It was concluded that the laser dose of 4 J/cm(2) was better compared to 1 J/cm(2) and allowed the wound healing process to accelerate.

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