The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography

The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound’s state during wound healing including the effect of low-dose photodynamic therapy using topical app...

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Autores principales: Zuhayri, Hala, Nikolaev, Viktor V., Lepekhina, Tatiana B., Sandykova, Ekaterina A., Krivova, Natalya A., Kistenev, Yury V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877015/
https://www.ncbi.nlm.nih.gov/pubmed/35214134
http://dx.doi.org/10.3390/pharmaceutics14020399
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author Zuhayri, Hala
Nikolaev, Viktor V.
Lepekhina, Tatiana B.
Sandykova, Ekaterina A.
Krivova, Natalya A.
Kistenev, Yury V.
author_facet Zuhayri, Hala
Nikolaev, Viktor V.
Lepekhina, Tatiana B.
Sandykova, Ekaterina A.
Krivova, Natalya A.
Kistenev, Yury V.
author_sort Zuhayri, Hala
collection PubMed
description The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound’s state during wound healing including the effect of low-dose photodynamic therapy using topical application of two different photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser doses of 1 J/cm(2) and 4 J/cm(2). It was concluded that the laser dose of 4 J/cm(2) was better compared to 1 J/cm(2) and allowed the wound healing process to accelerate.
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spelling pubmed-88770152022-02-26 The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography Zuhayri, Hala Nikolaev, Viktor V. Lepekhina, Tatiana B. Sandykova, Ekaterina A. Krivova, Natalya A. Kistenev, Yury V. Pharmaceutics Article The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound’s state during wound healing including the effect of low-dose photodynamic therapy using topical application of two different photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser doses of 1 J/cm(2) and 4 J/cm(2). It was concluded that the laser dose of 4 J/cm(2) was better compared to 1 J/cm(2) and allowed the wound healing process to accelerate. MDPI 2022-02-11 /pmc/articles/PMC8877015/ /pubmed/35214134 http://dx.doi.org/10.3390/pharmaceutics14020399 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zuhayri, Hala
Nikolaev, Viktor V.
Lepekhina, Tatiana B.
Sandykova, Ekaterina A.
Krivova, Natalya A.
Kistenev, Yury V.
The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography
title The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography
title_full The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography
title_fullStr The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography
title_full_unstemmed The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography
title_short The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography
title_sort in vivo quantitative assessment of the effectiveness of low-dose photodynamic therapy on wound healing using optical coherence tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877015/
https://www.ncbi.nlm.nih.gov/pubmed/35214134
http://dx.doi.org/10.3390/pharmaceutics14020399
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