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The Potential Role of Nutrition in Lung Cancer Establishment and Progression

Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment...

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Autores principales: Porro, Chiara, La Torre, Maria Ester, Tartaglia, Nicola, Benameur, Tarek, Santini, Mario, Ambrosi, Antonio, Messina, Giovanni, Cibelli, Giuseppe, Fiorelli, Alfonso, Polito, Rita, Messina, Gaetana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877211/
https://www.ncbi.nlm.nih.gov/pubmed/35207557
http://dx.doi.org/10.3390/life12020270
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author Porro, Chiara
La Torre, Maria Ester
Tartaglia, Nicola
Benameur, Tarek
Santini, Mario
Ambrosi, Antonio
Messina, Giovanni
Cibelli, Giuseppe
Fiorelli, Alfonso
Polito, Rita
Messina, Gaetana
author_facet Porro, Chiara
La Torre, Maria Ester
Tartaglia, Nicola
Benameur, Tarek
Santini, Mario
Ambrosi, Antonio
Messina, Giovanni
Cibelli, Giuseppe
Fiorelli, Alfonso
Polito, Rita
Messina, Gaetana
author_sort Porro, Chiara
collection PubMed
description Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment of lung cancer. Various factors appear to be involved in the development of the latter, such as cigarette smoking or certain external environmental factors. The increase in oxidative stress is therefore an integral part of the carcinogenesis process. The biological role of bioactive factors derived from adipose tissue, mainly adipokines, is implicated in various cancers, and an increasing body of evidence has shown that certain adipocytokines contribute to the development, progression and prognosis of lung cancer. Not all adipokines stimulate tumor growth; in fact, adiponectin inhibits carcinogenesis by regulating both cell growth and the levels of inflammatory cytokines. Adiponectin expression is deregulated in several cancer types. Many nutritional factors have been shown to increase adiponectin levels and therefore could be used as a new therapeutic strategy for combating lung cancer. In addition, foods with antioxidant and anti-inflammatory properties play a key role in the prevention of many human diseases, including lung cancer. The purpose of this review is to analyze the role of diet in lung cancer in order to recommend dietary habit and lifestyle changes to prevent or treat this pathology.
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spelling pubmed-88772112022-02-26 The Potential Role of Nutrition in Lung Cancer Establishment and Progression Porro, Chiara La Torre, Maria Ester Tartaglia, Nicola Benameur, Tarek Santini, Mario Ambrosi, Antonio Messina, Giovanni Cibelli, Giuseppe Fiorelli, Alfonso Polito, Rita Messina, Gaetana Life (Basel) Review Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment of lung cancer. Various factors appear to be involved in the development of the latter, such as cigarette smoking or certain external environmental factors. The increase in oxidative stress is therefore an integral part of the carcinogenesis process. The biological role of bioactive factors derived from adipose tissue, mainly adipokines, is implicated in various cancers, and an increasing body of evidence has shown that certain adipocytokines contribute to the development, progression and prognosis of lung cancer. Not all adipokines stimulate tumor growth; in fact, adiponectin inhibits carcinogenesis by regulating both cell growth and the levels of inflammatory cytokines. Adiponectin expression is deregulated in several cancer types. Many nutritional factors have been shown to increase adiponectin levels and therefore could be used as a new therapeutic strategy for combating lung cancer. In addition, foods with antioxidant and anti-inflammatory properties play a key role in the prevention of many human diseases, including lung cancer. The purpose of this review is to analyze the role of diet in lung cancer in order to recommend dietary habit and lifestyle changes to prevent or treat this pathology. MDPI 2022-02-12 /pmc/articles/PMC8877211/ /pubmed/35207557 http://dx.doi.org/10.3390/life12020270 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Porro, Chiara
La Torre, Maria Ester
Tartaglia, Nicola
Benameur, Tarek
Santini, Mario
Ambrosi, Antonio
Messina, Giovanni
Cibelli, Giuseppe
Fiorelli, Alfonso
Polito, Rita
Messina, Gaetana
The Potential Role of Nutrition in Lung Cancer Establishment and Progression
title The Potential Role of Nutrition in Lung Cancer Establishment and Progression
title_full The Potential Role of Nutrition in Lung Cancer Establishment and Progression
title_fullStr The Potential Role of Nutrition in Lung Cancer Establishment and Progression
title_full_unstemmed The Potential Role of Nutrition in Lung Cancer Establishment and Progression
title_short The Potential Role of Nutrition in Lung Cancer Establishment and Progression
title_sort potential role of nutrition in lung cancer establishment and progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877211/
https://www.ncbi.nlm.nih.gov/pubmed/35207557
http://dx.doi.org/10.3390/life12020270
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