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The Potential Role of Nutrition in Lung Cancer Establishment and Progression
Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877211/ https://www.ncbi.nlm.nih.gov/pubmed/35207557 http://dx.doi.org/10.3390/life12020270 |
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author | Porro, Chiara La Torre, Maria Ester Tartaglia, Nicola Benameur, Tarek Santini, Mario Ambrosi, Antonio Messina, Giovanni Cibelli, Giuseppe Fiorelli, Alfonso Polito, Rita Messina, Gaetana |
author_facet | Porro, Chiara La Torre, Maria Ester Tartaglia, Nicola Benameur, Tarek Santini, Mario Ambrosi, Antonio Messina, Giovanni Cibelli, Giuseppe Fiorelli, Alfonso Polito, Rita Messina, Gaetana |
author_sort | Porro, Chiara |
collection | PubMed |
description | Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment of lung cancer. Various factors appear to be involved in the development of the latter, such as cigarette smoking or certain external environmental factors. The increase in oxidative stress is therefore an integral part of the carcinogenesis process. The biological role of bioactive factors derived from adipose tissue, mainly adipokines, is implicated in various cancers, and an increasing body of evidence has shown that certain adipocytokines contribute to the development, progression and prognosis of lung cancer. Not all adipokines stimulate tumor growth; in fact, adiponectin inhibits carcinogenesis by regulating both cell growth and the levels of inflammatory cytokines. Adiponectin expression is deregulated in several cancer types. Many nutritional factors have been shown to increase adiponectin levels and therefore could be used as a new therapeutic strategy for combating lung cancer. In addition, foods with antioxidant and anti-inflammatory properties play a key role in the prevention of many human diseases, including lung cancer. The purpose of this review is to analyze the role of diet in lung cancer in order to recommend dietary habit and lifestyle changes to prevent or treat this pathology. |
format | Online Article Text |
id | pubmed-8877211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88772112022-02-26 The Potential Role of Nutrition in Lung Cancer Establishment and Progression Porro, Chiara La Torre, Maria Ester Tartaglia, Nicola Benameur, Tarek Santini, Mario Ambrosi, Antonio Messina, Giovanni Cibelli, Giuseppe Fiorelli, Alfonso Polito, Rita Messina, Gaetana Life (Basel) Review Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment of lung cancer. Various factors appear to be involved in the development of the latter, such as cigarette smoking or certain external environmental factors. The increase in oxidative stress is therefore an integral part of the carcinogenesis process. The biological role of bioactive factors derived from adipose tissue, mainly adipokines, is implicated in various cancers, and an increasing body of evidence has shown that certain adipocytokines contribute to the development, progression and prognosis of lung cancer. Not all adipokines stimulate tumor growth; in fact, adiponectin inhibits carcinogenesis by regulating both cell growth and the levels of inflammatory cytokines. Adiponectin expression is deregulated in several cancer types. Many nutritional factors have been shown to increase adiponectin levels and therefore could be used as a new therapeutic strategy for combating lung cancer. In addition, foods with antioxidant and anti-inflammatory properties play a key role in the prevention of many human diseases, including lung cancer. The purpose of this review is to analyze the role of diet in lung cancer in order to recommend dietary habit and lifestyle changes to prevent or treat this pathology. MDPI 2022-02-12 /pmc/articles/PMC8877211/ /pubmed/35207557 http://dx.doi.org/10.3390/life12020270 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Porro, Chiara La Torre, Maria Ester Tartaglia, Nicola Benameur, Tarek Santini, Mario Ambrosi, Antonio Messina, Giovanni Cibelli, Giuseppe Fiorelli, Alfonso Polito, Rita Messina, Gaetana The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
title | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
title_full | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
title_fullStr | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
title_full_unstemmed | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
title_short | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
title_sort | potential role of nutrition in lung cancer establishment and progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877211/ https://www.ncbi.nlm.nih.gov/pubmed/35207557 http://dx.doi.org/10.3390/life12020270 |
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