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Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics

Owing to bio-polymer’s low-cost, environmental friendliness and mechanically stable nature, calcium alginate microcapsules have attracted much interest for their applications in numerous fields. Among the common production methods, the Electrospraying technique has shown a great potential due to sma...

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Autores principales: Anani, Joshua, Noby, Hussien, Zkria, Abdelrahman, Yoshitake, Tsuyoshi, ElKady, Marwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877230/
https://www.ncbi.nlm.nih.gov/pubmed/35215622
http://dx.doi.org/10.3390/polym14040709
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author Anani, Joshua
Noby, Hussien
Zkria, Abdelrahman
Yoshitake, Tsuyoshi
ElKady, Marwa
author_facet Anani, Joshua
Noby, Hussien
Zkria, Abdelrahman
Yoshitake, Tsuyoshi
ElKady, Marwa
author_sort Anani, Joshua
collection PubMed
description Owing to bio-polymer’s low-cost, environmental friendliness and mechanically stable nature, calcium alginate microcapsules have attracted much interest for their applications in numerous fields. Among the common production methods, the Electrospraying technique has shown a great potential due to smaller shape capsule production and ease of control of independent affecting parameters. Although one factor at a time (OFAT) can predict the trends of parameter effect on size and sphericity, it is inefficient in explaining the complex parameter interaction of the electrospray process. In the current study, the effects of the main parameters affecting on size and sphericity of the microcapsules using OFAT were optimized to attain calcium alginate microcapsules with an average diameter below 100 µm. Furthermore, we propose a statistical model employing the Surface Responses Methodology (RSM) and Central Composite Design (CDD) to generate a quadratic order linear regression model for the microcapsule diameter and sphericity coefficient. Experimentally, microcapsules with a size of 92.586 µm and sphericity coefficient of 0.771 were predicted and obtained from an alginate concentration of 2.013 w/v, with a flowrate of 0.560 mL/h, a needle size of 27 G and a 2.024 w/v calcium chloride concentration as optimum parameters. The optimization processes were successfully aligned towards formation of the spherical microcapsules with smaller average diameter of less than 100 µm, owing to the applied high voltage that reached up to 21 kV.
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spelling pubmed-88772302022-02-26 Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics Anani, Joshua Noby, Hussien Zkria, Abdelrahman Yoshitake, Tsuyoshi ElKady, Marwa Polymers (Basel) Article Owing to bio-polymer’s low-cost, environmental friendliness and mechanically stable nature, calcium alginate microcapsules have attracted much interest for their applications in numerous fields. Among the common production methods, the Electrospraying technique has shown a great potential due to smaller shape capsule production and ease of control of independent affecting parameters. Although one factor at a time (OFAT) can predict the trends of parameter effect on size and sphericity, it is inefficient in explaining the complex parameter interaction of the electrospray process. In the current study, the effects of the main parameters affecting on size and sphericity of the microcapsules using OFAT were optimized to attain calcium alginate microcapsules with an average diameter below 100 µm. Furthermore, we propose a statistical model employing the Surface Responses Methodology (RSM) and Central Composite Design (CDD) to generate a quadratic order linear regression model for the microcapsule diameter and sphericity coefficient. Experimentally, microcapsules with a size of 92.586 µm and sphericity coefficient of 0.771 were predicted and obtained from an alginate concentration of 2.013 w/v, with a flowrate of 0.560 mL/h, a needle size of 27 G and a 2.024 w/v calcium chloride concentration as optimum parameters. The optimization processes were successfully aligned towards formation of the spherical microcapsules with smaller average diameter of less than 100 µm, owing to the applied high voltage that reached up to 21 kV. MDPI 2022-02-12 /pmc/articles/PMC8877230/ /pubmed/35215622 http://dx.doi.org/10.3390/polym14040709 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anani, Joshua
Noby, Hussien
Zkria, Abdelrahman
Yoshitake, Tsuyoshi
ElKady, Marwa
Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics
title Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics
title_full Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics
title_fullStr Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics
title_full_unstemmed Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics
title_short Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics
title_sort monothetic analysis and response surface methodology optimization of calcium alginate microcapsules characteristics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877230/
https://www.ncbi.nlm.nih.gov/pubmed/35215622
http://dx.doi.org/10.3390/polym14040709
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