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Peculiarities of the T Cell Immune Response in COVID-19

Understanding the T cell response to SARS-CoV-2 is critical to vaccine development, epidemiological surveillance, and control strategies for this disease. This review provides data from studies of the immune response in coronavirus infections. It describes general mechanisms of immunity, its T cell...

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Detalles Bibliográficos
Autores principales: Kudlay, Dmitry, Kofiadi, Ilya, Khaitov, Musa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877307/
https://www.ncbi.nlm.nih.gov/pubmed/35214700
http://dx.doi.org/10.3390/vaccines10020242
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author Kudlay, Dmitry
Kofiadi, Ilya
Khaitov, Musa
author_facet Kudlay, Dmitry
Kofiadi, Ilya
Khaitov, Musa
author_sort Kudlay, Dmitry
collection PubMed
description Understanding the T cell response to SARS-CoV-2 is critical to vaccine development, epidemiological surveillance, and control strategies for this disease. This review provides data from studies of the immune response in coronavirus infections. It describes general mechanisms of immunity, its T cell components, and presents a detailed scheme of the T cell response in SARS-CoV-2 infection, including from the standpoint of determining the most promising targets for assessing its level. In addition, we reviewed studies investigating post-vaccination immunity in the development of vaccines against COVID-19. This review also includes the peculiarities of immunity in different age and gender groups, and in the presence of a number of factors, for example, comorbidity or disease severity. This study summarizes the most informative methods for assessing the immune response to SARS-CoV-2 infection.
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spelling pubmed-88773072022-02-26 Peculiarities of the T Cell Immune Response in COVID-19 Kudlay, Dmitry Kofiadi, Ilya Khaitov, Musa Vaccines (Basel) Review Understanding the T cell response to SARS-CoV-2 is critical to vaccine development, epidemiological surveillance, and control strategies for this disease. This review provides data from studies of the immune response in coronavirus infections. It describes general mechanisms of immunity, its T cell components, and presents a detailed scheme of the T cell response in SARS-CoV-2 infection, including from the standpoint of determining the most promising targets for assessing its level. In addition, we reviewed studies investigating post-vaccination immunity in the development of vaccines against COVID-19. This review also includes the peculiarities of immunity in different age and gender groups, and in the presence of a number of factors, for example, comorbidity or disease severity. This study summarizes the most informative methods for assessing the immune response to SARS-CoV-2 infection. MDPI 2022-02-04 /pmc/articles/PMC8877307/ /pubmed/35214700 http://dx.doi.org/10.3390/vaccines10020242 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kudlay, Dmitry
Kofiadi, Ilya
Khaitov, Musa
Peculiarities of the T Cell Immune Response in COVID-19
title Peculiarities of the T Cell Immune Response in COVID-19
title_full Peculiarities of the T Cell Immune Response in COVID-19
title_fullStr Peculiarities of the T Cell Immune Response in COVID-19
title_full_unstemmed Peculiarities of the T Cell Immune Response in COVID-19
title_short Peculiarities of the T Cell Immune Response in COVID-19
title_sort peculiarities of the t cell immune response in covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877307/
https://www.ncbi.nlm.nih.gov/pubmed/35214700
http://dx.doi.org/10.3390/vaccines10020242
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