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Peculiarities of the T Cell Immune Response in COVID-19
Understanding the T cell response to SARS-CoV-2 is critical to vaccine development, epidemiological surveillance, and control strategies for this disease. This review provides data from studies of the immune response in coronavirus infections. It describes general mechanisms of immunity, its T cell...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877307/ https://www.ncbi.nlm.nih.gov/pubmed/35214700 http://dx.doi.org/10.3390/vaccines10020242 |
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author | Kudlay, Dmitry Kofiadi, Ilya Khaitov, Musa |
author_facet | Kudlay, Dmitry Kofiadi, Ilya Khaitov, Musa |
author_sort | Kudlay, Dmitry |
collection | PubMed |
description | Understanding the T cell response to SARS-CoV-2 is critical to vaccine development, epidemiological surveillance, and control strategies for this disease. This review provides data from studies of the immune response in coronavirus infections. It describes general mechanisms of immunity, its T cell components, and presents a detailed scheme of the T cell response in SARS-CoV-2 infection, including from the standpoint of determining the most promising targets for assessing its level. In addition, we reviewed studies investigating post-vaccination immunity in the development of vaccines against COVID-19. This review also includes the peculiarities of immunity in different age and gender groups, and in the presence of a number of factors, for example, comorbidity or disease severity. This study summarizes the most informative methods for assessing the immune response to SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-8877307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88773072022-02-26 Peculiarities of the T Cell Immune Response in COVID-19 Kudlay, Dmitry Kofiadi, Ilya Khaitov, Musa Vaccines (Basel) Review Understanding the T cell response to SARS-CoV-2 is critical to vaccine development, epidemiological surveillance, and control strategies for this disease. This review provides data from studies of the immune response in coronavirus infections. It describes general mechanisms of immunity, its T cell components, and presents a detailed scheme of the T cell response in SARS-CoV-2 infection, including from the standpoint of determining the most promising targets for assessing its level. In addition, we reviewed studies investigating post-vaccination immunity in the development of vaccines against COVID-19. This review also includes the peculiarities of immunity in different age and gender groups, and in the presence of a number of factors, for example, comorbidity or disease severity. This study summarizes the most informative methods for assessing the immune response to SARS-CoV-2 infection. MDPI 2022-02-04 /pmc/articles/PMC8877307/ /pubmed/35214700 http://dx.doi.org/10.3390/vaccines10020242 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kudlay, Dmitry Kofiadi, Ilya Khaitov, Musa Peculiarities of the T Cell Immune Response in COVID-19 |
title | Peculiarities of the T Cell Immune Response in COVID-19 |
title_full | Peculiarities of the T Cell Immune Response in COVID-19 |
title_fullStr | Peculiarities of the T Cell Immune Response in COVID-19 |
title_full_unstemmed | Peculiarities of the T Cell Immune Response in COVID-19 |
title_short | Peculiarities of the T Cell Immune Response in COVID-19 |
title_sort | peculiarities of the t cell immune response in covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877307/ https://www.ncbi.nlm.nih.gov/pubmed/35214700 http://dx.doi.org/10.3390/vaccines10020242 |
work_keys_str_mv | AT kudlaydmitry peculiaritiesofthetcellimmuneresponseincovid19 AT kofiadiilya peculiaritiesofthetcellimmuneresponseincovid19 AT khaitovmusa peculiaritiesofthetcellimmuneresponseincovid19 |