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Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies
We explored the molecular evolution of the spike gene after the administration of anti-spike monoclonal antibodies in patients with mild or moderate forms of COVID-19. Four out of the 13 patients acquired a mutation during follow-up; two mutations (G1204E and E406G) appeared as a mixture without cli...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877338/ https://www.ncbi.nlm.nih.gov/pubmed/35215820 http://dx.doi.org/10.3390/v14020226 |
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| author | Jary, Aude Marot, Stéphane Faycal, Antoine Leon, Sacha Sayon, Sophie Zafilaza, Karen Ghidaoui, Emna Quoc, Stéphanie Nguyen Nemlaghi, Safaa Choquet, Sylvain Dres, Martin Pourcher, Valérie Calvez, Vincent Junot, Helga Marcelin, Anne-Geneviève Soulié, Cathia |
| author_facet | Jary, Aude Marot, Stéphane Faycal, Antoine Leon, Sacha Sayon, Sophie Zafilaza, Karen Ghidaoui, Emna Quoc, Stéphanie Nguyen Nemlaghi, Safaa Choquet, Sylvain Dres, Martin Pourcher, Valérie Calvez, Vincent Junot, Helga Marcelin, Anne-Geneviève Soulié, Cathia |
| author_sort | Jary, Aude |
| collection | PubMed |
| description | We explored the molecular evolution of the spike gene after the administration of anti-spike monoclonal antibodies in patients with mild or moderate forms of COVID-19. Four out of the 13 patients acquired a mutation during follow-up; two mutations (G1204E and E406G) appeared as a mixture without clinical impact, while the Q493R mutation emerged in two patients (one receiving bamlanivimab and one receiving bamlanivimab/etesevimab) with fatal outcomes. Careful virological monitoring of patients treated with mAbs should be performed, especially in immunosuppressed patients. |
| format | Online Article Text |
| id | pubmed-8877338 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-88773382022-02-26 Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies Jary, Aude Marot, Stéphane Faycal, Antoine Leon, Sacha Sayon, Sophie Zafilaza, Karen Ghidaoui, Emna Quoc, Stéphanie Nguyen Nemlaghi, Safaa Choquet, Sylvain Dres, Martin Pourcher, Valérie Calvez, Vincent Junot, Helga Marcelin, Anne-Geneviève Soulié, Cathia Viruses Brief Report We explored the molecular evolution of the spike gene after the administration of anti-spike monoclonal antibodies in patients with mild or moderate forms of COVID-19. Four out of the 13 patients acquired a mutation during follow-up; two mutations (G1204E and E406G) appeared as a mixture without clinical impact, while the Q493R mutation emerged in two patients (one receiving bamlanivimab and one receiving bamlanivimab/etesevimab) with fatal outcomes. Careful virological monitoring of patients treated with mAbs should be performed, especially in immunosuppressed patients. MDPI 2022-01-24 /pmc/articles/PMC8877338/ /pubmed/35215820 http://dx.doi.org/10.3390/v14020226 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Brief Report Jary, Aude Marot, Stéphane Faycal, Antoine Leon, Sacha Sayon, Sophie Zafilaza, Karen Ghidaoui, Emna Quoc, Stéphanie Nguyen Nemlaghi, Safaa Choquet, Sylvain Dres, Martin Pourcher, Valérie Calvez, Vincent Junot, Helga Marcelin, Anne-Geneviève Soulié, Cathia Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies |
| title | Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies |
| title_full | Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies |
| title_fullStr | Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies |
| title_full_unstemmed | Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies |
| title_short | Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies |
| title_sort | spike gene evolution and immune escape mutations in patients with mild or moderate forms of covid-19 and treated with monoclonal antibodies therapies |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877338/ https://www.ncbi.nlm.nih.gov/pubmed/35215820 http://dx.doi.org/10.3390/v14020226 |
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