Crosstalk between Hepatitis B Virus and the 3D Genome Structure

Viruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expres...

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Autores principales: Dias, João Diogo, Sarica, Nazim, Cournac, Axel, Koszul, Romain, Neuveut, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877387/
https://www.ncbi.nlm.nih.gov/pubmed/35216038
http://dx.doi.org/10.3390/v14020445
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author Dias, João Diogo
Sarica, Nazim
Cournac, Axel
Koszul, Romain
Neuveut, Christine
author_facet Dias, João Diogo
Sarica, Nazim
Cournac, Axel
Koszul, Romain
Neuveut, Christine
author_sort Dias, João Diogo
collection PubMed
description Viruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expression. This review provides an updated overview on the current knowledge on how the hepatitis B virus interacts with the cellular 3D genome and its consequences on viral and cellular gene expression. We also briefly discuss the strategies developed by other DNA viruses to co-opt and sometimes subvert cellular genome spatial organization.
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spelling pubmed-88773872022-02-26 Crosstalk between Hepatitis B Virus and the 3D Genome Structure Dias, João Diogo Sarica, Nazim Cournac, Axel Koszul, Romain Neuveut, Christine Viruses Review Viruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expression. This review provides an updated overview on the current knowledge on how the hepatitis B virus interacts with the cellular 3D genome and its consequences on viral and cellular gene expression. We also briefly discuss the strategies developed by other DNA viruses to co-opt and sometimes subvert cellular genome spatial organization. MDPI 2022-02-21 /pmc/articles/PMC8877387/ /pubmed/35216038 http://dx.doi.org/10.3390/v14020445 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dias, João Diogo
Sarica, Nazim
Cournac, Axel
Koszul, Romain
Neuveut, Christine
Crosstalk between Hepatitis B Virus and the 3D Genome Structure
title Crosstalk between Hepatitis B Virus and the 3D Genome Structure
title_full Crosstalk between Hepatitis B Virus and the 3D Genome Structure
title_fullStr Crosstalk between Hepatitis B Virus and the 3D Genome Structure
title_full_unstemmed Crosstalk between Hepatitis B Virus and the 3D Genome Structure
title_short Crosstalk between Hepatitis B Virus and the 3D Genome Structure
title_sort crosstalk between hepatitis b virus and the 3d genome structure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877387/
https://www.ncbi.nlm.nih.gov/pubmed/35216038
http://dx.doi.org/10.3390/v14020445
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