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Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania

Background and Objectives: The occurrence of human immunodeficiency virus (HIV) infection in children in Romania has been reported since 1989. This retrospective study was aimed at assessing clinical and biological risk factors for mother-to-child transmission (MTCT) of HIV in two HIV-acquired immun...

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Autores principales: Cambrea, Simona Claudia, Marcu, Eugenia Andreea, Cucli, Elena, Badiu, Diana, Penciu, Roxana, Petcu, Cristian Lucian, Dumea, Elena, Halichidis, Stela, Pazara, Loredana, Mihai, Cristina Maria, Dumitrescu, Florentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877470/
https://www.ncbi.nlm.nih.gov/pubmed/35208597
http://dx.doi.org/10.3390/medicina58020275
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author Cambrea, Simona Claudia
Marcu, Eugenia Andreea
Cucli, Elena
Badiu, Diana
Penciu, Roxana
Petcu, Cristian Lucian
Dumea, Elena
Halichidis, Stela
Pazara, Loredana
Mihai, Cristina Maria
Dumitrescu, Florentina
author_facet Cambrea, Simona Claudia
Marcu, Eugenia Andreea
Cucli, Elena
Badiu, Diana
Penciu, Roxana
Petcu, Cristian Lucian
Dumea, Elena
Halichidis, Stela
Pazara, Loredana
Mihai, Cristina Maria
Dumitrescu, Florentina
author_sort Cambrea, Simona Claudia
collection PubMed
description Background and Objectives: The occurrence of human immunodeficiency virus (HIV) infection in children in Romania has been reported since 1989. This retrospective study was aimed at assessing clinical and biological risk factors for mother-to-child transmission (MTCT) of HIV in two HIV-acquired immune deficiency syndrome (AIDS) Regional Centers (RCs), Constanta and Craiova in Romania. Materials and Methods: During the study period (2008–2019), 408 HIV-positive pregnant women, 244 from Constanta RC and 164 from Craiova RC who attended antenatal visits, were included. All HIV-positive pregnant women were under combined antiretroviral therapy (cART) during pregnancy and childbirth, being followedup with their infants up to 18 months after delivery. We investigated the clinical as well as biological risk factorsassociated with increased MTCT of HIV. Results: Comparing different variables of HIV-positive pregnant women from the two HIV-AIDS CRs, we find that there are significant differences between the mean value of hemoglobin, CD4 level, environmental area, marital and amniotic membranes status, and HIV patient stage in the last trimester of pregnancy (p < 0.05), but without any differences in mother’s mean age, education level, type of delivery, breastfeeding, the duration of cART administration, HIV viral load, and survival rate. Conclusions: In 408 HIV-positive pregnant women followed up at two HIV-AIDS RCs in Romania, the most important clinical and biological risk factors associated with increased MTCT of HIV are represented by anemia, CD4 level, and HIV patient stage.
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spelling pubmed-88774702022-02-26 Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania Cambrea, Simona Claudia Marcu, Eugenia Andreea Cucli, Elena Badiu, Diana Penciu, Roxana Petcu, Cristian Lucian Dumea, Elena Halichidis, Stela Pazara, Loredana Mihai, Cristina Maria Dumitrescu, Florentina Medicina (Kaunas) Article Background and Objectives: The occurrence of human immunodeficiency virus (HIV) infection in children in Romania has been reported since 1989. This retrospective study was aimed at assessing clinical and biological risk factors for mother-to-child transmission (MTCT) of HIV in two HIV-acquired immune deficiency syndrome (AIDS) Regional Centers (RCs), Constanta and Craiova in Romania. Materials and Methods: During the study period (2008–2019), 408 HIV-positive pregnant women, 244 from Constanta RC and 164 from Craiova RC who attended antenatal visits, were included. All HIV-positive pregnant women were under combined antiretroviral therapy (cART) during pregnancy and childbirth, being followedup with their infants up to 18 months after delivery. We investigated the clinical as well as biological risk factorsassociated with increased MTCT of HIV. Results: Comparing different variables of HIV-positive pregnant women from the two HIV-AIDS CRs, we find that there are significant differences between the mean value of hemoglobin, CD4 level, environmental area, marital and amniotic membranes status, and HIV patient stage in the last trimester of pregnancy (p < 0.05), but without any differences in mother’s mean age, education level, type of delivery, breastfeeding, the duration of cART administration, HIV viral load, and survival rate. Conclusions: In 408 HIV-positive pregnant women followed up at two HIV-AIDS RCs in Romania, the most important clinical and biological risk factors associated with increased MTCT of HIV are represented by anemia, CD4 level, and HIV patient stage. MDPI 2022-02-11 /pmc/articles/PMC8877470/ /pubmed/35208597 http://dx.doi.org/10.3390/medicina58020275 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cambrea, Simona Claudia
Marcu, Eugenia Andreea
Cucli, Elena
Badiu, Diana
Penciu, Roxana
Petcu, Cristian Lucian
Dumea, Elena
Halichidis, Stela
Pazara, Loredana
Mihai, Cristina Maria
Dumitrescu, Florentina
Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania
title Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania
title_full Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania
title_fullStr Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania
title_full_unstemmed Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania
title_short Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania
title_sort clinical and biological risk factors associated with increased mother-to-child transmission of hiv in two south-east hiv-aids regional centers in romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877470/
https://www.ncbi.nlm.nih.gov/pubmed/35208597
http://dx.doi.org/10.3390/medicina58020275
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