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Achromobacter spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients

Achromobacter is an opportunistic pathogen that mainly causes chronic lung infections in cystic fibrosis (CF) patients and is associated with increased mortality. Little is known about Achromobacter spp. in the lung transplant recipient (LTXr) population. We aimed at describing rates of Achromobacte...

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Autores principales: Crone, Cornelia Geisler, Rezahosseini, Omid, Schultz, Hans Henrik Lawaetz, Qvist, Tavs, Johansen, Helle Krogh, Nielsen, Susanne Dam, Perch, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877520/
https://www.ncbi.nlm.nih.gov/pubmed/35215124
http://dx.doi.org/10.3390/pathogens11020181
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author Crone, Cornelia Geisler
Rezahosseini, Omid
Schultz, Hans Henrik Lawaetz
Qvist, Tavs
Johansen, Helle Krogh
Nielsen, Susanne Dam
Perch, Michael
author_facet Crone, Cornelia Geisler
Rezahosseini, Omid
Schultz, Hans Henrik Lawaetz
Qvist, Tavs
Johansen, Helle Krogh
Nielsen, Susanne Dam
Perch, Michael
author_sort Crone, Cornelia Geisler
collection PubMed
description Achromobacter is an opportunistic pathogen that mainly causes chronic lung infections in cystic fibrosis (CF) patients and is associated with increased mortality. Little is known about Achromobacter spp. in the lung transplant recipient (LTXr) population. We aimed at describing rates of Achromobacter spp. infection in LTXr prior to, in relation to, and after transplantation, as well as all-cause mortality proportion in infected and uninfected LTXr. We included 288 adult LTXr who underwent lung transplantation (LTX) between 1 January 2010 and 31 December 2019 in Denmark. Bronchoalveolar lavage was performed at regular intervals starting two weeks after transplantation. Positive cultures of Achromobacter spp. were identified in nationwide microbiology registries, and infections were categorized as persistent or transient, according to the proportion of positive cultures. A total of 11 of the 288 LTXr had transient (n = 7) or persistent (n = 4) Achromobacter spp. infection after LTX; CF was the underlying disease in 9 out of 11 LTXr. Three out of the four patients, with persistent infection after LTX, also had persistent infection before LTX. The cumulative incidence of the first episode of infection one year after LTX was 3.8% (95% CI: 1.6–6.0). The incidence rates of transient and persistent infection in the first year after LTX were 27 (12–53) and 15 (5–37) per 1000 person-years of follow-up, respectively. The all-cause mortality proportion one year after LTX was 27% in the Achromobacter spp. infected patients and 12% in the uninfected patients (p = 0.114). Achromobacter spp. mainly affected LTXr with CF as the underlying disease and was rare in non-CF LTXr. Larger studies are needed to assess long-term outcomes of Achromobacter spp. in LTXr.
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spelling pubmed-88775202022-02-26 Achromobacter spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients Crone, Cornelia Geisler Rezahosseini, Omid Schultz, Hans Henrik Lawaetz Qvist, Tavs Johansen, Helle Krogh Nielsen, Susanne Dam Perch, Michael Pathogens Article Achromobacter is an opportunistic pathogen that mainly causes chronic lung infections in cystic fibrosis (CF) patients and is associated with increased mortality. Little is known about Achromobacter spp. in the lung transplant recipient (LTXr) population. We aimed at describing rates of Achromobacter spp. infection in LTXr prior to, in relation to, and after transplantation, as well as all-cause mortality proportion in infected and uninfected LTXr. We included 288 adult LTXr who underwent lung transplantation (LTX) between 1 January 2010 and 31 December 2019 in Denmark. Bronchoalveolar lavage was performed at regular intervals starting two weeks after transplantation. Positive cultures of Achromobacter spp. were identified in nationwide microbiology registries, and infections were categorized as persistent or transient, according to the proportion of positive cultures. A total of 11 of the 288 LTXr had transient (n = 7) or persistent (n = 4) Achromobacter spp. infection after LTX; CF was the underlying disease in 9 out of 11 LTXr. Three out of the four patients, with persistent infection after LTX, also had persistent infection before LTX. The cumulative incidence of the first episode of infection one year after LTX was 3.8% (95% CI: 1.6–6.0). The incidence rates of transient and persistent infection in the first year after LTX were 27 (12–53) and 15 (5–37) per 1000 person-years of follow-up, respectively. The all-cause mortality proportion one year after LTX was 27% in the Achromobacter spp. infected patients and 12% in the uninfected patients (p = 0.114). Achromobacter spp. mainly affected LTXr with CF as the underlying disease and was rare in non-CF LTXr. Larger studies are needed to assess long-term outcomes of Achromobacter spp. in LTXr. MDPI 2022-01-28 /pmc/articles/PMC8877520/ /pubmed/35215124 http://dx.doi.org/10.3390/pathogens11020181 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Crone, Cornelia Geisler
Rezahosseini, Omid
Schultz, Hans Henrik Lawaetz
Qvist, Tavs
Johansen, Helle Krogh
Nielsen, Susanne Dam
Perch, Michael
Achromobacter spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients
title Achromobacter spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients
title_full Achromobacter spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients
title_fullStr Achromobacter spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients
title_full_unstemmed Achromobacter spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients
title_short Achromobacter spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients
title_sort achromobacter spp. in a cohort of non-selected pre- and post-lung transplant recipients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877520/
https://www.ncbi.nlm.nih.gov/pubmed/35215124
http://dx.doi.org/10.3390/pathogens11020181
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