Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application

We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine whether a pharmacokinetic (PK)/pharmacodynamic (PD)...

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Detalles Bibliográficos
Autores principales: Alvarez, Jean Claude, Davido, Benjamin, Moine, Pierre, Etting, Isabelle, Annane, Djillali, Larabi, Islam Amine, Simon, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877570/
https://www.ncbi.nlm.nih.gov/pubmed/35215368
http://dx.doi.org/10.3390/ph15020256

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