Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age

Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression to severe COVID-19. In this study, we investigated levels of circulating IFNα a...

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Detalles Bibliográficos
Autores principales: Alidjinou, Enagnon Kazali, Hirabidian, Mickael, Rabat, Anthony, Ouafi, Mahdi, Nekoua, Magloire Pandoua, Sane, Famara, Poissy, Julien, Hober, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877658/
https://www.ncbi.nlm.nih.gov/pubmed/35207234
http://dx.doi.org/10.3390/jcm11040961
Descripción
Sumario:Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression to severe COVID-19. In this study, we investigated levels of circulating IFNα and serum neutralizing activity in COVID-19 patients admitted to the intensive care unit. We found a significant association of levels of IFNα with age (p = 0.007). This association has also been observed in a cohort of COVID-19 outpatients with mild infection (p = 0.02). The impact of senescence on IFN response can explain the higher susceptibility of the elderly to severe COVID-19.

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