Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age

Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression to severe COVID-19. In this study, we investigated levels of circulating IFNα a...

Descripción completa

Detalles Bibliográficos
Autores principales: Alidjinou, Enagnon Kazali, Hirabidian, Mickael, Rabat, Anthony, Ouafi, Mahdi, Nekoua, Magloire Pandoua, Sane, Famara, Poissy, Julien, Hober, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877658/
https://www.ncbi.nlm.nih.gov/pubmed/35207234
http://dx.doi.org/10.3390/jcm11040961
_version_ 1784658472394031104
author Alidjinou, Enagnon Kazali
Hirabidian, Mickael
Rabat, Anthony
Ouafi, Mahdi
Nekoua, Magloire Pandoua
Sane, Famara
Poissy, Julien
Hober, Didier
author_facet Alidjinou, Enagnon Kazali
Hirabidian, Mickael
Rabat, Anthony
Ouafi, Mahdi
Nekoua, Magloire Pandoua
Sane, Famara
Poissy, Julien
Hober, Didier
author_sort Alidjinou, Enagnon Kazali
collection PubMed
description Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression to severe COVID-19. In this study, we investigated levels of circulating IFNα and serum neutralizing activity in COVID-19 patients admitted to the intensive care unit. We found a significant association of levels of IFNα with age (p = 0.007). This association has also been observed in a cohort of COVID-19 outpatients with mild infection (p = 0.02). The impact of senescence on IFN response can explain the higher susceptibility of the elderly to severe COVID-19.
format Online
Article
Text
id pubmed-8877658
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88776582022-02-26 Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age Alidjinou, Enagnon Kazali Hirabidian, Mickael Rabat, Anthony Ouafi, Mahdi Nekoua, Magloire Pandoua Sane, Famara Poissy, Julien Hober, Didier J Clin Med Article Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression to severe COVID-19. In this study, we investigated levels of circulating IFNα and serum neutralizing activity in COVID-19 patients admitted to the intensive care unit. We found a significant association of levels of IFNα with age (p = 0.007). This association has also been observed in a cohort of COVID-19 outpatients with mild infection (p = 0.02). The impact of senescence on IFN response can explain the higher susceptibility of the elderly to severe COVID-19. MDPI 2022-02-12 /pmc/articles/PMC8877658/ /pubmed/35207234 http://dx.doi.org/10.3390/jcm11040961 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alidjinou, Enagnon Kazali
Hirabidian, Mickael
Rabat, Anthony
Ouafi, Mahdi
Nekoua, Magloire Pandoua
Sane, Famara
Poissy, Julien
Hober, Didier
Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age
title Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age
title_full Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age
title_fullStr Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age
title_full_unstemmed Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age
title_short Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age
title_sort low serum levels of interferon alpha in covid-19 patients are associated with older age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877658/
https://www.ncbi.nlm.nih.gov/pubmed/35207234
http://dx.doi.org/10.3390/jcm11040961
work_keys_str_mv AT alidjinouenagnonkazali lowserumlevelsofinterferonalphaincovid19patientsareassociatedwitholderage
AT hirabidianmickael lowserumlevelsofinterferonalphaincovid19patientsareassociatedwitholderage
AT rabatanthony lowserumlevelsofinterferonalphaincovid19patientsareassociatedwitholderage
AT ouafimahdi lowserumlevelsofinterferonalphaincovid19patientsareassociatedwitholderage
AT nekouamagloirepandoua lowserumlevelsofinterferonalphaincovid19patientsareassociatedwitholderage
AT sanefamara lowserumlevelsofinterferonalphaincovid19patientsareassociatedwitholderage
AT poissyjulien lowserumlevelsofinterferonalphaincovid19patientsareassociatedwitholderage
AT hoberdidier lowserumlevelsofinterferonalphaincovid19patientsareassociatedwitholderage
AT lowserumlevelsofinterferonalphaincovid19patientsareassociatedwitholderage

Ejemplares similares