Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post‐mortem motor cortex and cerebrospinal fluid

Although the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) are not yet fully understood, several studies report alterations in tau phosphorylation in both sporadic and familial ALS. Recently, we have demonstrated that phosphorylated tau at S396 (pTau‐S396) is mislocalized to sy...

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Detalles Bibliográficos
Autores principales: Petrozziello, Tiziana, Amaral, Ana C., Dujardin, Simon, Farhan, Sali M. K., Chan, James, Trombetta, Bianca A., Kivisäkk, Pia, Mills, Alexandra N., Bordt, Evan A., Kim, Spencer E., Dooley, Patrick M., Commins, Caitlin, Connors, Theresa R., Oakley, Derek H., Ghosal, Anubrata, Gomez‐Isla, Teresa, Hyman, Bradley T., Arnold, Steven E., Spires‐Jones, Tara, Cudkowicz, Merit E., Berry, James D., Sadri‐Vakili, Ghazaleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877756/
https://www.ncbi.nlm.nih.gov/pubmed/34779076
http://dx.doi.org/10.1111/bpa.13035

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