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Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy

Background: Organ donation (OD) remains the only therapeutic option for end-stage disease in some cases. Unfortunately, the gap between donors and recipients is still substantial. Trauma patients represent a potential yet underestimated pool of organ donors. In this article, we present our data on O...

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Autores principales: Altomare, Michele, Bekhor, Shir Sara, Cioffi, Stefano Piero Bernardo, Sacchi, Marco, Renzi, Federica, Spota, Andrea, Bini, Roberto, Ambrogi, Federico, Pozzi, Federico, Chieregato, Arturo, Chiara, Osvaldo, Cimbanassi, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877798/
https://www.ncbi.nlm.nih.gov/pubmed/35207501
http://dx.doi.org/10.3390/life12020214
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author Altomare, Michele
Bekhor, Shir Sara
Cioffi, Stefano Piero Bernardo
Sacchi, Marco
Renzi, Federica
Spota, Andrea
Bini, Roberto
Ambrogi, Federico
Pozzi, Federico
Chieregato, Arturo
Chiara, Osvaldo
Cimbanassi, Stefania
author_facet Altomare, Michele
Bekhor, Shir Sara
Cioffi, Stefano Piero Bernardo
Sacchi, Marco
Renzi, Federica
Spota, Andrea
Bini, Roberto
Ambrogi, Federico
Pozzi, Federico
Chieregato, Arturo
Chiara, Osvaldo
Cimbanassi, Stefania
author_sort Altomare, Michele
collection PubMed
description Background: Organ donation (OD) remains the only therapeutic option for end-stage disease in some cases. Unfortunately, the gap between donors and recipients is still substantial. Trauma patients represent a potential yet underestimated pool of organ donors. In this article, we present our data on OD after damage control strategy (DCS). Materials and Methods: A retrospective, observational cohort study was conducted through a complete revision of data of consecutive adult trauma patients (>18 years old) who underwent OD after DCS between January 2018 and May 2021. Four subgroups were created [Liver (Li), Lungs (Lu), Heart (H), Kidneys (K)] to compare variables between those who donated the organ of interest and those who did not. Results: Thirty-six patients underwent OD after DCS. Six patients (16.7%) were excluded: 2(5.6%) for missing data about admission; 4(11.1%) didn’t receive DCS. Mean ISS was 47.2 (SD ± 17.4). Number of donated organs was 113 with an organs/patient ratio of 3.8. The functional response rate was 91.2%. Ten organs (8.8%) had primary nonfunction after transplantation: 2/15 hearts (13.3%), 1/28 livers (3.6%), 4/53 kidneys (7.5%) and 3/5 pancreases (60%). No lung primary nonfunction were registered. Complete results of subgroup analysis are reported in supplementary materials. Conclusion: Organ donation should be considered a possible outcome in any trauma patient. Aggressive damage control strategy doesn’t affect the functional response rate of transplanted organs.
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spelling pubmed-88777982022-02-26 Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy Altomare, Michele Bekhor, Shir Sara Cioffi, Stefano Piero Bernardo Sacchi, Marco Renzi, Federica Spota, Andrea Bini, Roberto Ambrogi, Federico Pozzi, Federico Chieregato, Arturo Chiara, Osvaldo Cimbanassi, Stefania Life (Basel) Article Background: Organ donation (OD) remains the only therapeutic option for end-stage disease in some cases. Unfortunately, the gap between donors and recipients is still substantial. Trauma patients represent a potential yet underestimated pool of organ donors. In this article, we present our data on OD after damage control strategy (DCS). Materials and Methods: A retrospective, observational cohort study was conducted through a complete revision of data of consecutive adult trauma patients (>18 years old) who underwent OD after DCS between January 2018 and May 2021. Four subgroups were created [Liver (Li), Lungs (Lu), Heart (H), Kidneys (K)] to compare variables between those who donated the organ of interest and those who did not. Results: Thirty-six patients underwent OD after DCS. Six patients (16.7%) were excluded: 2(5.6%) for missing data about admission; 4(11.1%) didn’t receive DCS. Mean ISS was 47.2 (SD ± 17.4). Number of donated organs was 113 with an organs/patient ratio of 3.8. The functional response rate was 91.2%. Ten organs (8.8%) had primary nonfunction after transplantation: 2/15 hearts (13.3%), 1/28 livers (3.6%), 4/53 kidneys (7.5%) and 3/5 pancreases (60%). No lung primary nonfunction were registered. Complete results of subgroup analysis are reported in supplementary materials. Conclusion: Organ donation should be considered a possible outcome in any trauma patient. Aggressive damage control strategy doesn’t affect the functional response rate of transplanted organs. MDPI 2022-01-30 /pmc/articles/PMC8877798/ /pubmed/35207501 http://dx.doi.org/10.3390/life12020214 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Altomare, Michele
Bekhor, Shir Sara
Cioffi, Stefano Piero Bernardo
Sacchi, Marco
Renzi, Federica
Spota, Andrea
Bini, Roberto
Ambrogi, Federico
Pozzi, Federico
Chieregato, Arturo
Chiara, Osvaldo
Cimbanassi, Stefania
Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy
title Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy
title_full Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy
title_fullStr Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy
title_full_unstemmed Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy
title_short Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy
title_sort organ donation after damage control strategy in trauma patients: experience from first level trauma center in italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877798/
https://www.ncbi.nlm.nih.gov/pubmed/35207501
http://dx.doi.org/10.3390/life12020214
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