Cargando…
Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction
The present review summarizes the current knowledge concerning provenance, properties, physiological and therapeutic actions of elderberry and the bioactive molecules present in the plant, with emphasis on their action on female reproduction. Elderberry or black elder (Sambucus nigra L.) attracts at...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877800/ https://www.ncbi.nlm.nih.gov/pubmed/35215351 http://dx.doi.org/10.3390/ph15020239 |
_version_ | 1784658505321414656 |
---|---|
author | Kolesarova, Adriana Baldovska, Simona Kohut, Ladislav Sirotkin, Alexander V. |
author_facet | Kolesarova, Adriana Baldovska, Simona Kohut, Ladislav Sirotkin, Alexander V. |
author_sort | Kolesarova, Adriana |
collection | PubMed |
description | The present review summarizes the current knowledge concerning provenance, properties, physiological and therapeutic actions of elderberry and the bioactive molecules present in the plant, with emphasis on their action on female reproduction. Elderberry or black elder (Sambucus nigra L.) attracts attention due to its easy cultivation and high availability of bioactive compounds. Most of the available data concerning black elder’s therapeutic action are focused on its effects such as activation of immune processes and anti-inflammatory processes (cytokine production, etc.) and regulation of hormones and their receptors in cancer cells. The effects of elderberry on reproduction have been poorly investigated so far. Nevertheless, conducted studies so far demonstrate the stimulatory influence of black elder extract and its constituents, such as rutin, anthocyanins and agglutinins, on the viability and steroidogenesis of healthy ovarian cells as well as their ability to promote apoptosis and reduce the viability and proliferation of ovarian cancer cells. Furthermore, the action of black elder extract and its constituent biomolecules, such as anthocyanins and lectins, on embryogenesis and the embryonal estradiol-estradiol receptor system have also been reported. The available information, despite limitations, suggest the applicability of black elder constituents for improvement of reproductive processes in animal biotechnology, animal production and assisted reproduction, as well as for prevention and treatment of reproductive disorders (including cancer) in veterinary and human medicine. |
format | Online Article Text |
id | pubmed-8877800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88778002022-02-26 Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction Kolesarova, Adriana Baldovska, Simona Kohut, Ladislav Sirotkin, Alexander V. Pharmaceuticals (Basel) Review The present review summarizes the current knowledge concerning provenance, properties, physiological and therapeutic actions of elderberry and the bioactive molecules present in the plant, with emphasis on their action on female reproduction. Elderberry or black elder (Sambucus nigra L.) attracts attention due to its easy cultivation and high availability of bioactive compounds. Most of the available data concerning black elder’s therapeutic action are focused on its effects such as activation of immune processes and anti-inflammatory processes (cytokine production, etc.) and regulation of hormones and their receptors in cancer cells. The effects of elderberry on reproduction have been poorly investigated so far. Nevertheless, conducted studies so far demonstrate the stimulatory influence of black elder extract and its constituents, such as rutin, anthocyanins and agglutinins, on the viability and steroidogenesis of healthy ovarian cells as well as their ability to promote apoptosis and reduce the viability and proliferation of ovarian cancer cells. Furthermore, the action of black elder extract and its constituent biomolecules, such as anthocyanins and lectins, on embryogenesis and the embryonal estradiol-estradiol receptor system have also been reported. The available information, despite limitations, suggest the applicability of black elder constituents for improvement of reproductive processes in animal biotechnology, animal production and assisted reproduction, as well as for prevention and treatment of reproductive disorders (including cancer) in veterinary and human medicine. MDPI 2022-02-17 /pmc/articles/PMC8877800/ /pubmed/35215351 http://dx.doi.org/10.3390/ph15020239 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kolesarova, Adriana Baldovska, Simona Kohut, Ladislav Sirotkin, Alexander V. Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
title | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
title_full | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
title_fullStr | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
title_full_unstemmed | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
title_short | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
title_sort | black elder and its constituents: molecular mechanisms of action associated with female reproduction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877800/ https://www.ncbi.nlm.nih.gov/pubmed/35215351 http://dx.doi.org/10.3390/ph15020239 |
work_keys_str_mv | AT kolesarovaadriana blackelderanditsconstituentsmolecularmechanismsofactionassociatedwithfemalereproduction AT baldovskasimona blackelderanditsconstituentsmolecularmechanismsofactionassociatedwithfemalereproduction AT kohutladislav blackelderanditsconstituentsmolecularmechanismsofactionassociatedwithfemalereproduction AT sirotkinalexanderv blackelderanditsconstituentsmolecularmechanismsofactionassociatedwithfemalereproduction |