Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

PR-104A is a dual hypoxia/nitroreductase gene therapy prodrug by virtue of its ability to undergo either one- or two-electron reduction to its cytotoxic species. It has been evaluated extensively in pre-clinical GDEPT studies, yet off-target human aldo-keto reductase AKR1C3-mediated activation has l...

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Detalles Bibliográficos
Autores principales: Ashoorzadeh, Amir, Mowday, Alexandra M., Guise, Christopher P., Silva, Shevan, Bull, Matthew R., Abbattista, Maria R., Copp, Janine N., Williams, Elsie M., Ackerley, David F., Patterson, Adam V., Smaill, Jeff B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877822/
https://www.ncbi.nlm.nih.gov/pubmed/35215297
http://dx.doi.org/10.3390/ph15020185

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