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Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction

Fetal growth restriction (FGR), when undetected antenatally, is the biggest risk factor for preventable stillbirth. Maternal circulating SPINT1 is reduced in pregnancies, which ultimately deliver small for gestational age (SGA) infants at term (birthweight < 10th centile), compared to appropriate...

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Autores principales: Murphy, Ciara N., Cluver, Catherine A., Walker, Susan P., Keenan, Emerson, Hastie, Roxanne, MacDonald, Teresa M., Hannan, Natalie J., Brownfoot, Fiona C., Cannon, Ping, Tong, Stephen, Kaitu’u-Lino, Tu’uhevaha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877863/
https://www.ncbi.nlm.nih.gov/pubmed/35207174
http://dx.doi.org/10.3390/jcm11040901
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author Murphy, Ciara N.
Cluver, Catherine A.
Walker, Susan P.
Keenan, Emerson
Hastie, Roxanne
MacDonald, Teresa M.
Hannan, Natalie J.
Brownfoot, Fiona C.
Cannon, Ping
Tong, Stephen
Kaitu’u-Lino, Tu’uhevaha J.
author_facet Murphy, Ciara N.
Cluver, Catherine A.
Walker, Susan P.
Keenan, Emerson
Hastie, Roxanne
MacDonald, Teresa M.
Hannan, Natalie J.
Brownfoot, Fiona C.
Cannon, Ping
Tong, Stephen
Kaitu’u-Lino, Tu’uhevaha J.
author_sort Murphy, Ciara N.
collection PubMed
description Fetal growth restriction (FGR), when undetected antenatally, is the biggest risk factor for preventable stillbirth. Maternal circulating SPINT1 is reduced in pregnancies, which ultimately deliver small for gestational age (SGA) infants at term (birthweight < 10th centile), compared to appropriate for gestational age (AGA) infants (birthweight ≥ 10th centile). SPINT1 is also reduced in FGR diagnosed before 34 weeks’ gestation. We hypothesised that circulating SPINT1 would be decreased in co-existing preterm preeclampsia and FGR. Plasma SPINT1 was measured in samples obtained from two double-blind, randomised therapeutic trials. In the Preeclampsia Intervention with Esomeprazole trial, circulating SPINT1 was decreased in women with preeclampsia who delivered SGA infants (n = 75, median = 18,857 pg/mL, IQR 10,782–29,890 pg/mL, p < 0.0001), relative to those delivering AGA (n = 22, median = 40,168 pg/mL, IQR 22,342–75,172 pg/mL). This was confirmed in the Preeclampsia Intervention 2 with metformin trial where levels of SPINT1 in maternal circulation were reduced in SGA pregnancies (n = 95, median = 57,764 pg/mL, IQR 42,212–91,356 pg/mL, p < 0.0001) compared to AGA controls (n = 40, median = 107,062 pg/mL, IQR 70,183–176,532 pg/mL). Placental Growth Factor (PlGF) and sFlt-1 were also measured. PlGF was significantly reduced in the SGA pregnancies, while ratios of sFlt-1/SPINT1 and sFlt1/PlGF were significantly increased. This is the first study to demonstrate significantly reduced SPINT1 in co-existing FGR and preeclamptic pregnancies.
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spelling pubmed-88778632022-02-26 Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction Murphy, Ciara N. Cluver, Catherine A. Walker, Susan P. Keenan, Emerson Hastie, Roxanne MacDonald, Teresa M. Hannan, Natalie J. Brownfoot, Fiona C. Cannon, Ping Tong, Stephen Kaitu’u-Lino, Tu’uhevaha J. J Clin Med Article Fetal growth restriction (FGR), when undetected antenatally, is the biggest risk factor for preventable stillbirth. Maternal circulating SPINT1 is reduced in pregnancies, which ultimately deliver small for gestational age (SGA) infants at term (birthweight < 10th centile), compared to appropriate for gestational age (AGA) infants (birthweight ≥ 10th centile). SPINT1 is also reduced in FGR diagnosed before 34 weeks’ gestation. We hypothesised that circulating SPINT1 would be decreased in co-existing preterm preeclampsia and FGR. Plasma SPINT1 was measured in samples obtained from two double-blind, randomised therapeutic trials. In the Preeclampsia Intervention with Esomeprazole trial, circulating SPINT1 was decreased in women with preeclampsia who delivered SGA infants (n = 75, median = 18,857 pg/mL, IQR 10,782–29,890 pg/mL, p < 0.0001), relative to those delivering AGA (n = 22, median = 40,168 pg/mL, IQR 22,342–75,172 pg/mL). This was confirmed in the Preeclampsia Intervention 2 with metformin trial where levels of SPINT1 in maternal circulation were reduced in SGA pregnancies (n = 95, median = 57,764 pg/mL, IQR 42,212–91,356 pg/mL, p < 0.0001) compared to AGA controls (n = 40, median = 107,062 pg/mL, IQR 70,183–176,532 pg/mL). Placental Growth Factor (PlGF) and sFlt-1 were also measured. PlGF was significantly reduced in the SGA pregnancies, while ratios of sFlt-1/SPINT1 and sFlt1/PlGF were significantly increased. This is the first study to demonstrate significantly reduced SPINT1 in co-existing FGR and preeclamptic pregnancies. MDPI 2022-02-09 /pmc/articles/PMC8877863/ /pubmed/35207174 http://dx.doi.org/10.3390/jcm11040901 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Murphy, Ciara N.
Cluver, Catherine A.
Walker, Susan P.
Keenan, Emerson
Hastie, Roxanne
MacDonald, Teresa M.
Hannan, Natalie J.
Brownfoot, Fiona C.
Cannon, Ping
Tong, Stephen
Kaitu’u-Lino, Tu’uhevaha J.
Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction
title Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction
title_full Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction
title_fullStr Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction
title_full_unstemmed Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction
title_short Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction
title_sort circulating spint1 is reduced in a preeclamptic cohort with co-existing fetal growth restriction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877863/
https://www.ncbi.nlm.nih.gov/pubmed/35207174
http://dx.doi.org/10.3390/jcm11040901
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