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Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019
Although thrombosis in coronavirus disease 2019 (COVID-19) infection has attracted attention, the mechanism underlying its development remains unclear. The relationship between platelet activation and the severity of COVID-19 infection was compared with that involving other infections. Plasma solubl...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877880/ https://www.ncbi.nlm.nih.gov/pubmed/35207258 http://dx.doi.org/10.3390/jcm11040985 |
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author | Wada, Hideo Ichikawa, Yuhuko Ezaki, Minoru Yamamoto, Akitaka Tomida, Masaki Yoshida, Masamichi Fukui, Shunsuke Moritani, Isao Shiraki, Katsuya Shimaoka, Motomu Iba, Toshiaki Suzuki-Inoue, Katsue Shimpo, Hideto |
author_facet | Wada, Hideo Ichikawa, Yuhuko Ezaki, Minoru Yamamoto, Akitaka Tomida, Masaki Yoshida, Masamichi Fukui, Shunsuke Moritani, Isao Shiraki, Katsuya Shimaoka, Motomu Iba, Toshiaki Suzuki-Inoue, Katsue Shimpo, Hideto |
author_sort | Wada, Hideo |
collection | PubMed |
description | Although thrombosis in coronavirus disease 2019 (COVID-19) infection has attracted attention, the mechanism underlying its development remains unclear. The relationship between platelet activation and the severity of COVID-19 infection was compared with that involving other infections. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2) levels were measured in 46 patients with COVID-19 infection and in 127 patients with other infections. The plasma sCLEC-2 levels in patients with COVID-19 infection {median (25th, 75th percentile), 489 (355, 668) ng/L} were significantly higher (p < 0.001) in comparison to patients suffering from other pneumonia {276 (183, 459) ng/L}, and the plasma sCLEC-2 levels of COVID-19 patients with severe {641 (406, 781) ng/L} or critical illness {776 (627, 860) ng/L} were significantly higher (p < 0.01, respectively) in comparison to those with mild illness {375 (278, 484) ng/L}. The ratio of the sCLEC-2 levels to platelets in COVID-19 patients with critical illness of infection was significantly higher (p < 0.01, p < 0.001 and p < 0.05, respectively) in comparison to COVID-19 patients with mild, moderate or severe illness. Plasma sCLEC-2 levels were significantly higher in patients with COVID-19 infection than in those with other infections, suggesting that platelet activation is triggered and facilitated by COVID-19 infection. |
format | Online Article Text |
id | pubmed-8877880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88778802022-02-26 Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019 Wada, Hideo Ichikawa, Yuhuko Ezaki, Minoru Yamamoto, Akitaka Tomida, Masaki Yoshida, Masamichi Fukui, Shunsuke Moritani, Isao Shiraki, Katsuya Shimaoka, Motomu Iba, Toshiaki Suzuki-Inoue, Katsue Shimpo, Hideto J Clin Med Article Although thrombosis in coronavirus disease 2019 (COVID-19) infection has attracted attention, the mechanism underlying its development remains unclear. The relationship between platelet activation and the severity of COVID-19 infection was compared with that involving other infections. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2) levels were measured in 46 patients with COVID-19 infection and in 127 patients with other infections. The plasma sCLEC-2 levels in patients with COVID-19 infection {median (25th, 75th percentile), 489 (355, 668) ng/L} were significantly higher (p < 0.001) in comparison to patients suffering from other pneumonia {276 (183, 459) ng/L}, and the plasma sCLEC-2 levels of COVID-19 patients with severe {641 (406, 781) ng/L} or critical illness {776 (627, 860) ng/L} were significantly higher (p < 0.01, respectively) in comparison to those with mild illness {375 (278, 484) ng/L}. The ratio of the sCLEC-2 levels to platelets in COVID-19 patients with critical illness of infection was significantly higher (p < 0.01, p < 0.001 and p < 0.05, respectively) in comparison to COVID-19 patients with mild, moderate or severe illness. Plasma sCLEC-2 levels were significantly higher in patients with COVID-19 infection than in those with other infections, suggesting that platelet activation is triggered and facilitated by COVID-19 infection. MDPI 2022-02-14 /pmc/articles/PMC8877880/ /pubmed/35207258 http://dx.doi.org/10.3390/jcm11040985 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wada, Hideo Ichikawa, Yuhuko Ezaki, Minoru Yamamoto, Akitaka Tomida, Masaki Yoshida, Masamichi Fukui, Shunsuke Moritani, Isao Shiraki, Katsuya Shimaoka, Motomu Iba, Toshiaki Suzuki-Inoue, Katsue Shimpo, Hideto Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019 |
title | Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019 |
title_full | Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019 |
title_fullStr | Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019 |
title_full_unstemmed | Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019 |
title_short | Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019 |
title_sort | elevated plasma soluble c-type lectin-like receptor 2 is associated with the worsening of coronavirus disease 2019 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877880/ https://www.ncbi.nlm.nih.gov/pubmed/35207258 http://dx.doi.org/10.3390/jcm11040985 |
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