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Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019

Although thrombosis in coronavirus disease 2019 (COVID-19) infection has attracted attention, the mechanism underlying its development remains unclear. The relationship between platelet activation and the severity of COVID-19 infection was compared with that involving other infections. Plasma solubl...

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Autores principales: Wada, Hideo, Ichikawa, Yuhuko, Ezaki, Minoru, Yamamoto, Akitaka, Tomida, Masaki, Yoshida, Masamichi, Fukui, Shunsuke, Moritani, Isao, Shiraki, Katsuya, Shimaoka, Motomu, Iba, Toshiaki, Suzuki-Inoue, Katsue, Shimpo, Hideto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877880/
https://www.ncbi.nlm.nih.gov/pubmed/35207258
http://dx.doi.org/10.3390/jcm11040985
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author Wada, Hideo
Ichikawa, Yuhuko
Ezaki, Minoru
Yamamoto, Akitaka
Tomida, Masaki
Yoshida, Masamichi
Fukui, Shunsuke
Moritani, Isao
Shiraki, Katsuya
Shimaoka, Motomu
Iba, Toshiaki
Suzuki-Inoue, Katsue
Shimpo, Hideto
author_facet Wada, Hideo
Ichikawa, Yuhuko
Ezaki, Minoru
Yamamoto, Akitaka
Tomida, Masaki
Yoshida, Masamichi
Fukui, Shunsuke
Moritani, Isao
Shiraki, Katsuya
Shimaoka, Motomu
Iba, Toshiaki
Suzuki-Inoue, Katsue
Shimpo, Hideto
author_sort Wada, Hideo
collection PubMed
description Although thrombosis in coronavirus disease 2019 (COVID-19) infection has attracted attention, the mechanism underlying its development remains unclear. The relationship between platelet activation and the severity of COVID-19 infection was compared with that involving other infections. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2) levels were measured in 46 patients with COVID-19 infection and in 127 patients with other infections. The plasma sCLEC-2 levels in patients with COVID-19 infection {median (25th, 75th percentile), 489 (355, 668) ng/L} were significantly higher (p < 0.001) in comparison to patients suffering from other pneumonia {276 (183, 459) ng/L}, and the plasma sCLEC-2 levels of COVID-19 patients with severe {641 (406, 781) ng/L} or critical illness {776 (627, 860) ng/L} were significantly higher (p < 0.01, respectively) in comparison to those with mild illness {375 (278, 484) ng/L}. The ratio of the sCLEC-2 levels to platelets in COVID-19 patients with critical illness of infection was significantly higher (p < 0.01, p < 0.001 and p < 0.05, respectively) in comparison to COVID-19 patients with mild, moderate or severe illness. Plasma sCLEC-2 levels were significantly higher in patients with COVID-19 infection than in those with other infections, suggesting that platelet activation is triggered and facilitated by COVID-19 infection.
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spelling pubmed-88778802022-02-26 Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019 Wada, Hideo Ichikawa, Yuhuko Ezaki, Minoru Yamamoto, Akitaka Tomida, Masaki Yoshida, Masamichi Fukui, Shunsuke Moritani, Isao Shiraki, Katsuya Shimaoka, Motomu Iba, Toshiaki Suzuki-Inoue, Katsue Shimpo, Hideto J Clin Med Article Although thrombosis in coronavirus disease 2019 (COVID-19) infection has attracted attention, the mechanism underlying its development remains unclear. The relationship between platelet activation and the severity of COVID-19 infection was compared with that involving other infections. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2) levels were measured in 46 patients with COVID-19 infection and in 127 patients with other infections. The plasma sCLEC-2 levels in patients with COVID-19 infection {median (25th, 75th percentile), 489 (355, 668) ng/L} were significantly higher (p < 0.001) in comparison to patients suffering from other pneumonia {276 (183, 459) ng/L}, and the plasma sCLEC-2 levels of COVID-19 patients with severe {641 (406, 781) ng/L} or critical illness {776 (627, 860) ng/L} were significantly higher (p < 0.01, respectively) in comparison to those with mild illness {375 (278, 484) ng/L}. The ratio of the sCLEC-2 levels to platelets in COVID-19 patients with critical illness of infection was significantly higher (p < 0.01, p < 0.001 and p < 0.05, respectively) in comparison to COVID-19 patients with mild, moderate or severe illness. Plasma sCLEC-2 levels were significantly higher in patients with COVID-19 infection than in those with other infections, suggesting that platelet activation is triggered and facilitated by COVID-19 infection. MDPI 2022-02-14 /pmc/articles/PMC8877880/ /pubmed/35207258 http://dx.doi.org/10.3390/jcm11040985 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wada, Hideo
Ichikawa, Yuhuko
Ezaki, Minoru
Yamamoto, Akitaka
Tomida, Masaki
Yoshida, Masamichi
Fukui, Shunsuke
Moritani, Isao
Shiraki, Katsuya
Shimaoka, Motomu
Iba, Toshiaki
Suzuki-Inoue, Katsue
Shimpo, Hideto
Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019
title Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019
title_full Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019
title_fullStr Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019
title_full_unstemmed Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019
title_short Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019
title_sort elevated plasma soluble c-type lectin-like receptor 2 is associated with the worsening of coronavirus disease 2019
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877880/
https://www.ncbi.nlm.nih.gov/pubmed/35207258
http://dx.doi.org/10.3390/jcm11040985
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