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Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions

We previously reported on the effects of a lactobacilli probiotic (SynForU-HerCare; two capsules/day of 9.5 log CFU/capsule) in improving symptoms of vaginal irritation, discharge and burning in pregnant women with vaginal candidiasis upon administration for 8 weeks, accompanied by improved emotiona...

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Autores principales: Ang, Xin Yee, Mageswaran, Uma Mageswary, Chung, Yi Li Fiona, Lee, Boon Kiat, Azhar, Siti Nur Afiqah, Roslan, Nurhanis Syazni, Saufian, Ili Farhana Binti, Mustaffa, Nor Sheila, Kalam, Ermadina Mohamad, Ibrahim, Aini Farhah, Abdul Wahid, Normala, Deris, Zakuan Zainy, Oon, Chern-Ein, Adnan, Wan Fadhlina Wan, Sany, Salina, Liong, Min-Tze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877909/
https://www.ncbi.nlm.nih.gov/pubmed/35208739
http://dx.doi.org/10.3390/microorganisms10020285
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author Ang, Xin Yee
Mageswaran, Uma Mageswary
Chung, Yi Li Fiona
Lee, Boon Kiat
Azhar, Siti Nur Afiqah
Roslan, Nurhanis Syazni
Saufian, Ili Farhana Binti
Mustaffa, Nor Sheila
Kalam, Ermadina Mohamad
Ibrahim, Aini Farhah
Abdul Wahid, Normala
Deris, Zakuan Zainy
Oon, Chern-Ein
Adnan, Wan Fadhlina Wan
Sany, Salina
Liong, Min-Tze
author_facet Ang, Xin Yee
Mageswaran, Uma Mageswary
Chung, Yi Li Fiona
Lee, Boon Kiat
Azhar, Siti Nur Afiqah
Roslan, Nurhanis Syazni
Saufian, Ili Farhana Binti
Mustaffa, Nor Sheila
Kalam, Ermadina Mohamad
Ibrahim, Aini Farhah
Abdul Wahid, Normala
Deris, Zakuan Zainy
Oon, Chern-Ein
Adnan, Wan Fadhlina Wan
Sany, Salina
Liong, Min-Tze
author_sort Ang, Xin Yee
collection PubMed
description We previously reported on the effects of a lactobacilli probiotic (SynForU-HerCare; two capsules/day of 9.5 log CFU/capsule) in improving symptoms of vaginal irritation, discharge and burning in pregnant women with vaginal candidiasis upon administration for 8 weeks, accompanied by improved emotional and social quality of life parameters. Thus, the present study aimed to analyse vaginal microbiota and inflammatory changes in hope to better understand the improved clinical symptoms as observed previously. Patients in the probiotic group showed a decreased abundance of Candida glabrata after 8 weeks (p = 0.009) in the lower vaginal region, while patients in the placebo group did not show any changes over time. In the higher vaginal and cervicovaginal regions, patients in the placebo group showed a decreased abundance of Candida albicans only within 4 weeks (p < 0.05) but no changes in abundance of C. glabrata over time, while patients in the probiotic group showed a continuous decreased abundance of C. albicans and C. glabrata over 8 weeks (p < 0.05). Patients in the placebo group also had a decreased abundance of Lactobacillus crispatus over 4 weeks (p = 0.023) in the lower vaginal region and a decreased abundance of L. jensenii over 8 weeks in the cervicovaginal region (p = 0.001). Meanwhile, patients in the probiotic group had an increased abundance of L. crispatus in the lower vaginal region after 8 weeks (p = 0.012) and Lactobacillus jensenii over 4 weeks in the cervicovaginal region (p < 0.001). Inflammation may have occurred in both low and high vaginal regions, predominantly observed by the increased concentration of pro-inflammatory cytokine TNF-alpha in patients from the placebo group (p < 0.05), while the administration of probiotics has shortened the period of inflammation as observed from the reduced need for anti-inflammatory cytokine IL-4 and IL-10 over time (p < 0.05). Taken together, our present new data further support previous findings that probiotic SynForU-HerCare had a beneficial effect against vaginal candidiasis in pregnant women via modulation of the vaginal microbiota and microenvironment.
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spelling pubmed-88779092022-02-26 Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions Ang, Xin Yee Mageswaran, Uma Mageswary Chung, Yi Li Fiona Lee, Boon Kiat Azhar, Siti Nur Afiqah Roslan, Nurhanis Syazni Saufian, Ili Farhana Binti Mustaffa, Nor Sheila Kalam, Ermadina Mohamad Ibrahim, Aini Farhah Abdul Wahid, Normala Deris, Zakuan Zainy Oon, Chern-Ein Adnan, Wan Fadhlina Wan Sany, Salina Liong, Min-Tze Microorganisms Article We previously reported on the effects of a lactobacilli probiotic (SynForU-HerCare; two capsules/day of 9.5 log CFU/capsule) in improving symptoms of vaginal irritation, discharge and burning in pregnant women with vaginal candidiasis upon administration for 8 weeks, accompanied by improved emotional and social quality of life parameters. Thus, the present study aimed to analyse vaginal microbiota and inflammatory changes in hope to better understand the improved clinical symptoms as observed previously. Patients in the probiotic group showed a decreased abundance of Candida glabrata after 8 weeks (p = 0.009) in the lower vaginal region, while patients in the placebo group did not show any changes over time. In the higher vaginal and cervicovaginal regions, patients in the placebo group showed a decreased abundance of Candida albicans only within 4 weeks (p < 0.05) but no changes in abundance of C. glabrata over time, while patients in the probiotic group showed a continuous decreased abundance of C. albicans and C. glabrata over 8 weeks (p < 0.05). Patients in the placebo group also had a decreased abundance of Lactobacillus crispatus over 4 weeks (p = 0.023) in the lower vaginal region and a decreased abundance of L. jensenii over 8 weeks in the cervicovaginal region (p = 0.001). Meanwhile, patients in the probiotic group had an increased abundance of L. crispatus in the lower vaginal region after 8 weeks (p = 0.012) and Lactobacillus jensenii over 4 weeks in the cervicovaginal region (p < 0.001). Inflammation may have occurred in both low and high vaginal regions, predominantly observed by the increased concentration of pro-inflammatory cytokine TNF-alpha in patients from the placebo group (p < 0.05), while the administration of probiotics has shortened the period of inflammation as observed from the reduced need for anti-inflammatory cytokine IL-4 and IL-10 over time (p < 0.05). Taken together, our present new data further support previous findings that probiotic SynForU-HerCare had a beneficial effect against vaginal candidiasis in pregnant women via modulation of the vaginal microbiota and microenvironment. MDPI 2022-01-26 /pmc/articles/PMC8877909/ /pubmed/35208739 http://dx.doi.org/10.3390/microorganisms10020285 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ang, Xin Yee
Mageswaran, Uma Mageswary
Chung, Yi Li Fiona
Lee, Boon Kiat
Azhar, Siti Nur Afiqah
Roslan, Nurhanis Syazni
Saufian, Ili Farhana Binti
Mustaffa, Nor Sheila
Kalam, Ermadina Mohamad
Ibrahim, Aini Farhah
Abdul Wahid, Normala
Deris, Zakuan Zainy
Oon, Chern-Ein
Adnan, Wan Fadhlina Wan
Sany, Salina
Liong, Min-Tze
Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions
title Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions
title_full Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions
title_fullStr Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions
title_full_unstemmed Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions
title_short Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions
title_sort probiotics reduce vaginal candidiasis in pregnant women via modulating abundance of candida and lactobacillus in vaginal and cervicovaginal regions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877909/
https://www.ncbi.nlm.nih.gov/pubmed/35208739
http://dx.doi.org/10.3390/microorganisms10020285
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