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Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions
We previously reported on the effects of a lactobacilli probiotic (SynForU-HerCare; two capsules/day of 9.5 log CFU/capsule) in improving symptoms of vaginal irritation, discharge and burning in pregnant women with vaginal candidiasis upon administration for 8 weeks, accompanied by improved emotiona...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877909/ https://www.ncbi.nlm.nih.gov/pubmed/35208739 http://dx.doi.org/10.3390/microorganisms10020285 |
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author | Ang, Xin Yee Mageswaran, Uma Mageswary Chung, Yi Li Fiona Lee, Boon Kiat Azhar, Siti Nur Afiqah Roslan, Nurhanis Syazni Saufian, Ili Farhana Binti Mustaffa, Nor Sheila Kalam, Ermadina Mohamad Ibrahim, Aini Farhah Abdul Wahid, Normala Deris, Zakuan Zainy Oon, Chern-Ein Adnan, Wan Fadhlina Wan Sany, Salina Liong, Min-Tze |
author_facet | Ang, Xin Yee Mageswaran, Uma Mageswary Chung, Yi Li Fiona Lee, Boon Kiat Azhar, Siti Nur Afiqah Roslan, Nurhanis Syazni Saufian, Ili Farhana Binti Mustaffa, Nor Sheila Kalam, Ermadina Mohamad Ibrahim, Aini Farhah Abdul Wahid, Normala Deris, Zakuan Zainy Oon, Chern-Ein Adnan, Wan Fadhlina Wan Sany, Salina Liong, Min-Tze |
author_sort | Ang, Xin Yee |
collection | PubMed |
description | We previously reported on the effects of a lactobacilli probiotic (SynForU-HerCare; two capsules/day of 9.5 log CFU/capsule) in improving symptoms of vaginal irritation, discharge and burning in pregnant women with vaginal candidiasis upon administration for 8 weeks, accompanied by improved emotional and social quality of life parameters. Thus, the present study aimed to analyse vaginal microbiota and inflammatory changes in hope to better understand the improved clinical symptoms as observed previously. Patients in the probiotic group showed a decreased abundance of Candida glabrata after 8 weeks (p = 0.009) in the lower vaginal region, while patients in the placebo group did not show any changes over time. In the higher vaginal and cervicovaginal regions, patients in the placebo group showed a decreased abundance of Candida albicans only within 4 weeks (p < 0.05) but no changes in abundance of C. glabrata over time, while patients in the probiotic group showed a continuous decreased abundance of C. albicans and C. glabrata over 8 weeks (p < 0.05). Patients in the placebo group also had a decreased abundance of Lactobacillus crispatus over 4 weeks (p = 0.023) in the lower vaginal region and a decreased abundance of L. jensenii over 8 weeks in the cervicovaginal region (p = 0.001). Meanwhile, patients in the probiotic group had an increased abundance of L. crispatus in the lower vaginal region after 8 weeks (p = 0.012) and Lactobacillus jensenii over 4 weeks in the cervicovaginal region (p < 0.001). Inflammation may have occurred in both low and high vaginal regions, predominantly observed by the increased concentration of pro-inflammatory cytokine TNF-alpha in patients from the placebo group (p < 0.05), while the administration of probiotics has shortened the period of inflammation as observed from the reduced need for anti-inflammatory cytokine IL-4 and IL-10 over time (p < 0.05). Taken together, our present new data further support previous findings that probiotic SynForU-HerCare had a beneficial effect against vaginal candidiasis in pregnant women via modulation of the vaginal microbiota and microenvironment. |
format | Online Article Text |
id | pubmed-8877909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88779092022-02-26 Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions Ang, Xin Yee Mageswaran, Uma Mageswary Chung, Yi Li Fiona Lee, Boon Kiat Azhar, Siti Nur Afiqah Roslan, Nurhanis Syazni Saufian, Ili Farhana Binti Mustaffa, Nor Sheila Kalam, Ermadina Mohamad Ibrahim, Aini Farhah Abdul Wahid, Normala Deris, Zakuan Zainy Oon, Chern-Ein Adnan, Wan Fadhlina Wan Sany, Salina Liong, Min-Tze Microorganisms Article We previously reported on the effects of a lactobacilli probiotic (SynForU-HerCare; two capsules/day of 9.5 log CFU/capsule) in improving symptoms of vaginal irritation, discharge and burning in pregnant women with vaginal candidiasis upon administration for 8 weeks, accompanied by improved emotional and social quality of life parameters. Thus, the present study aimed to analyse vaginal microbiota and inflammatory changes in hope to better understand the improved clinical symptoms as observed previously. Patients in the probiotic group showed a decreased abundance of Candida glabrata after 8 weeks (p = 0.009) in the lower vaginal region, while patients in the placebo group did not show any changes over time. In the higher vaginal and cervicovaginal regions, patients in the placebo group showed a decreased abundance of Candida albicans only within 4 weeks (p < 0.05) but no changes in abundance of C. glabrata over time, while patients in the probiotic group showed a continuous decreased abundance of C. albicans and C. glabrata over 8 weeks (p < 0.05). Patients in the placebo group also had a decreased abundance of Lactobacillus crispatus over 4 weeks (p = 0.023) in the lower vaginal region and a decreased abundance of L. jensenii over 8 weeks in the cervicovaginal region (p = 0.001). Meanwhile, patients in the probiotic group had an increased abundance of L. crispatus in the lower vaginal region after 8 weeks (p = 0.012) and Lactobacillus jensenii over 4 weeks in the cervicovaginal region (p < 0.001). Inflammation may have occurred in both low and high vaginal regions, predominantly observed by the increased concentration of pro-inflammatory cytokine TNF-alpha in patients from the placebo group (p < 0.05), while the administration of probiotics has shortened the period of inflammation as observed from the reduced need for anti-inflammatory cytokine IL-4 and IL-10 over time (p < 0.05). Taken together, our present new data further support previous findings that probiotic SynForU-HerCare had a beneficial effect against vaginal candidiasis in pregnant women via modulation of the vaginal microbiota and microenvironment. MDPI 2022-01-26 /pmc/articles/PMC8877909/ /pubmed/35208739 http://dx.doi.org/10.3390/microorganisms10020285 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ang, Xin Yee Mageswaran, Uma Mageswary Chung, Yi Li Fiona Lee, Boon Kiat Azhar, Siti Nur Afiqah Roslan, Nurhanis Syazni Saufian, Ili Farhana Binti Mustaffa, Nor Sheila Kalam, Ermadina Mohamad Ibrahim, Aini Farhah Abdul Wahid, Normala Deris, Zakuan Zainy Oon, Chern-Ein Adnan, Wan Fadhlina Wan Sany, Salina Liong, Min-Tze Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions |
title | Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions |
title_full | Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions |
title_fullStr | Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions |
title_full_unstemmed | Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions |
title_short | Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions |
title_sort | probiotics reduce vaginal candidiasis in pregnant women via modulating abundance of candida and lactobacillus in vaginal and cervicovaginal regions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877909/ https://www.ncbi.nlm.nih.gov/pubmed/35208739 http://dx.doi.org/10.3390/microorganisms10020285 |
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