The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947

The LuxS protein, encoded by luxS, is required for the production of autoinducer 2 (AI-2) in Streptococcus pneumoniae. The AI-2 molecule serves as a quorum sensing signal, and thus regulates cellular processes such as carbohydrate utilisation and biofilm formation, as well as impacting virulence. Th...

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Autores principales: Tikhomirova, Alexandra, Brazel, Erin B., McLean, Kimberley T., Agnew, Hannah N., Paton, James C., Trappetti, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877971/
https://www.ncbi.nlm.nih.gov/pubmed/35215159
http://dx.doi.org/10.3390/pathogens11020216
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author Tikhomirova, Alexandra
Brazel, Erin B.
McLean, Kimberley T.
Agnew, Hannah N.
Paton, James C.
Trappetti, Claudia
author_facet Tikhomirova, Alexandra
Brazel, Erin B.
McLean, Kimberley T.
Agnew, Hannah N.
Paton, James C.
Trappetti, Claudia
author_sort Tikhomirova, Alexandra
collection PubMed
description The LuxS protein, encoded by luxS, is required for the production of autoinducer 2 (AI-2) in Streptococcus pneumoniae. The AI-2 molecule serves as a quorum sensing signal, and thus regulates cellular processes such as carbohydrate utilisation and biofilm formation, as well as impacting virulence. The role of luxS in S. pneumoniae biology and lifestyle has been predominantly assessed in the laboratory strain D39. However, as biofilm formation, which is regulated by luxS, is critical for the ability of S. pneumoniae to cause otitis media, we investigated the role of luxS in a middle ear isolate, strain 947. Our results identified luxS to have a role in prevention of S. pneumoniae transition from colonisation of the nasopharynx to the ear, and in facilitating adherence to host epithelial cells.
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spelling pubmed-88779712022-02-26 The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947 Tikhomirova, Alexandra Brazel, Erin B. McLean, Kimberley T. Agnew, Hannah N. Paton, James C. Trappetti, Claudia Pathogens Article The LuxS protein, encoded by luxS, is required for the production of autoinducer 2 (AI-2) in Streptococcus pneumoniae. The AI-2 molecule serves as a quorum sensing signal, and thus regulates cellular processes such as carbohydrate utilisation and biofilm formation, as well as impacting virulence. The role of luxS in S. pneumoniae biology and lifestyle has been predominantly assessed in the laboratory strain D39. However, as biofilm formation, which is regulated by luxS, is critical for the ability of S. pneumoniae to cause otitis media, we investigated the role of luxS in a middle ear isolate, strain 947. Our results identified luxS to have a role in prevention of S. pneumoniae transition from colonisation of the nasopharynx to the ear, and in facilitating adherence to host epithelial cells. MDPI 2022-02-07 /pmc/articles/PMC8877971/ /pubmed/35215159 http://dx.doi.org/10.3390/pathogens11020216 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tikhomirova, Alexandra
Brazel, Erin B.
McLean, Kimberley T.
Agnew, Hannah N.
Paton, James C.
Trappetti, Claudia
The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947
title The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947
title_full The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947
title_fullStr The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947
title_full_unstemmed The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947
title_short The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947
title_sort role of luxs in the middle ear streptococcus pneumoniae isolate 947
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877971/
https://www.ncbi.nlm.nih.gov/pubmed/35215159
http://dx.doi.org/10.3390/pathogens11020216
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