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An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals

Tetrode arrays are a standard method for neuronal recordings in behaving animals, especially for chronic recordings of many neurons in freely-moving animals. OBJECTIVE. We sought to simplify tetrode drive designs with the aim of enabling building and implanting a 16-tetrode drive in a single day. AP...

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Autores principales: Voigts, Jakob, Newman, Jonathan P, Wilson, Matthew A, Harnett, Mark T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878001/
https://www.ncbi.nlm.nih.gov/pubmed/32074511
http://dx.doi.org/10.1088/1741-2552/ab77f9
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author Voigts, Jakob
Newman, Jonathan P
Wilson, Matthew A
Harnett, Mark T
author_facet Voigts, Jakob
Newman, Jonathan P
Wilson, Matthew A
Harnett, Mark T
author_sort Voigts, Jakob
collection PubMed
description Tetrode arrays are a standard method for neuronal recordings in behaving animals, especially for chronic recordings of many neurons in freely-moving animals. OBJECTIVE. We sought to simplify tetrode drive designs with the aim of enabling building and implanting a 16-tetrode drive in a single day. APPROACH. Our design makes use of recently developed technologies to reduce the complexity of the drive while maintaining a low weight. MAIN RESULTS. The design presents an improvement over existing implants in terms of robustness, weight, and ease of use. We describe two variants: a 16 tetrode implant weighing ~2 g for mice, bats, tree shrews and similar animals, and a 64 tetrode implant weighing ~16 g for rats and similar animals. These designs were co-developed and optimized alongside a new class of drive-mounted feature-rich amplifier boards with ultra-thin radio-frequency tethers, as described in an upcoming paper (Newman, Zhang et al in prep). SIGNIFICANCE. This design significantly improves the data yield of chronic electrophysiology experiments.
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spelling pubmed-88780012022-02-25 An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals Voigts, Jakob Newman, Jonathan P Wilson, Matthew A Harnett, Mark T J Neural Eng Article Tetrode arrays are a standard method for neuronal recordings in behaving animals, especially for chronic recordings of many neurons in freely-moving animals. OBJECTIVE. We sought to simplify tetrode drive designs with the aim of enabling building and implanting a 16-tetrode drive in a single day. APPROACH. Our design makes use of recently developed technologies to reduce the complexity of the drive while maintaining a low weight. MAIN RESULTS. The design presents an improvement over existing implants in terms of robustness, weight, and ease of use. We describe two variants: a 16 tetrode implant weighing ~2 g for mice, bats, tree shrews and similar animals, and a 64 tetrode implant weighing ~16 g for rats and similar animals. These designs were co-developed and optimized alongside a new class of drive-mounted feature-rich amplifier boards with ultra-thin radio-frequency tethers, as described in an upcoming paper (Newman, Zhang et al in prep). SIGNIFICANCE. This design significantly improves the data yield of chronic electrophysiology experiments. 2020-05-19 /pmc/articles/PMC8878001/ /pubmed/32074511 http://dx.doi.org/10.1088/1741-2552/ab77f9 Text en https://creativecommons.org/licenses/by/4.0/Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence.
spellingShingle Article
Voigts, Jakob
Newman, Jonathan P
Wilson, Matthew A
Harnett, Mark T
An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals
title An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals
title_full An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals
title_fullStr An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals
title_full_unstemmed An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals
title_short An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals
title_sort easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878001/
https://www.ncbi.nlm.nih.gov/pubmed/32074511
http://dx.doi.org/10.1088/1741-2552/ab77f9
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