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Prediction of Cortical Bone Thickness Variations in the Tibial Diaphysis of Running Rats

A cell-mechanobiological model is used for the prediction of bone density variation in rat tibiae under medium and high mechanical loads. The proposed theoretical-numerical model has only four parameters that need to be identified experimentally. It was used on three groups of male Wistar rats under...

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Autores principales: George, Daniel, Pallu, Stéphane, Bourzac, Céline, Wazzani, Rkia, Allena, Rachele, Rémond, Yves, Portier, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878138/
https://www.ncbi.nlm.nih.gov/pubmed/35207520
http://dx.doi.org/10.3390/life12020233
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author George, Daniel
Pallu, Stéphane
Bourzac, Céline
Wazzani, Rkia
Allena, Rachele
Rémond, Yves
Portier, Hugues
author_facet George, Daniel
Pallu, Stéphane
Bourzac, Céline
Wazzani, Rkia
Allena, Rachele
Rémond, Yves
Portier, Hugues
author_sort George, Daniel
collection PubMed
description A cell-mechanobiological model is used for the prediction of bone density variation in rat tibiae under medium and high mechanical loads. The proposed theoretical-numerical model has only four parameters that need to be identified experimentally. It was used on three groups of male Wistar rats under sedentary, moderate intermittent and continuous running scenarios over an eight week period. The theoretical numerical model was able to predict an increase in bone density under intermittent running (medium intensity mechanical load) and a decrease of bone density under continuous running (higher intensity mechanical load). The numerical predictions were well correlated with the experimental observations of cortical bone thickness variations, and the experimental results of cell activity enabled us to validate the numerical results predictions. The proposed model shows a good capacity to predict bone density variation through medium and high mechanical loads. The mechanobiological balance between osteoblast and osteoclast activity seems to be validated and a foreseen prediction of bone density is made available.
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spelling pubmed-88781382022-02-26 Prediction of Cortical Bone Thickness Variations in the Tibial Diaphysis of Running Rats George, Daniel Pallu, Stéphane Bourzac, Céline Wazzani, Rkia Allena, Rachele Rémond, Yves Portier, Hugues Life (Basel) Article A cell-mechanobiological model is used for the prediction of bone density variation in rat tibiae under medium and high mechanical loads. The proposed theoretical-numerical model has only four parameters that need to be identified experimentally. It was used on three groups of male Wistar rats under sedentary, moderate intermittent and continuous running scenarios over an eight week period. The theoretical numerical model was able to predict an increase in bone density under intermittent running (medium intensity mechanical load) and a decrease of bone density under continuous running (higher intensity mechanical load). The numerical predictions were well correlated with the experimental observations of cortical bone thickness variations, and the experimental results of cell activity enabled us to validate the numerical results predictions. The proposed model shows a good capacity to predict bone density variation through medium and high mechanical loads. The mechanobiological balance between osteoblast and osteoclast activity seems to be validated and a foreseen prediction of bone density is made available. MDPI 2022-02-03 /pmc/articles/PMC8878138/ /pubmed/35207520 http://dx.doi.org/10.3390/life12020233 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
George, Daniel
Pallu, Stéphane
Bourzac, Céline
Wazzani, Rkia
Allena, Rachele
Rémond, Yves
Portier, Hugues
Prediction of Cortical Bone Thickness Variations in the Tibial Diaphysis of Running Rats
title Prediction of Cortical Bone Thickness Variations in the Tibial Diaphysis of Running Rats
title_full Prediction of Cortical Bone Thickness Variations in the Tibial Diaphysis of Running Rats
title_fullStr Prediction of Cortical Bone Thickness Variations in the Tibial Diaphysis of Running Rats
title_full_unstemmed Prediction of Cortical Bone Thickness Variations in the Tibial Diaphysis of Running Rats
title_short Prediction of Cortical Bone Thickness Variations in the Tibial Diaphysis of Running Rats
title_sort prediction of cortical bone thickness variations in the tibial diaphysis of running rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878138/
https://www.ncbi.nlm.nih.gov/pubmed/35207520
http://dx.doi.org/10.3390/life12020233
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