Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their (13)C-NMR Spectroscopic Data Characteristics

Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using (13)C-NMR will be used. Overall, 75 compounds are categorized int...

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Detalles Bibliográficos
Autores principales: Abdelkarem, Fahd M., Abouelela, Mohamed E., Kamel, Mohamed R., Nafady, Alaa M., Allam, Ahmed E., Abdel-Rahman, Iman A. M., Almatroudi, Ahmad, Alrumaihi, Faris, Allemailem, Khaled S., Assaf, Hamdy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878145/
https://www.ncbi.nlm.nih.gov/pubmed/35200668
http://dx.doi.org/10.3390/md20020139
Descripción
Sumario:Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using (13)C-NMR will be used. Overall, 75 compounds are categorized into five major groups: gorgost-5-ene, 5,6-epoxygorgostane, 5,6-dihydroxygorgostane, 9,11-secogorgostane, and 23-demethylgorgostane, in addition to miscellaneous gorgostane. The structural diversity, selectivity for marine organisms, and biological effects of gorgostane steroids have generated considerable interest in the field of drug discovery research.

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