Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their (13)C-NMR Spectroscopic Data Characteristics

Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using (13)C-NMR will be used. Overall, 75 compounds are categorized int...

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Autores principales: Abdelkarem, Fahd M., Abouelela, Mohamed E., Kamel, Mohamed R., Nafady, Alaa M., Allam, Ahmed E., Abdel-Rahman, Iman A. M., Almatroudi, Ahmad, Alrumaihi, Faris, Allemailem, Khaled S., Assaf, Hamdy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878145/
https://www.ncbi.nlm.nih.gov/pubmed/35200668
http://dx.doi.org/10.3390/md20020139
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author Abdelkarem, Fahd M.
Abouelela, Mohamed E.
Kamel, Mohamed R.
Nafady, Alaa M.
Allam, Ahmed E.
Abdel-Rahman, Iman A. M.
Almatroudi, Ahmad
Alrumaihi, Faris
Allemailem, Khaled S.
Assaf, Hamdy K.
author_facet Abdelkarem, Fahd M.
Abouelela, Mohamed E.
Kamel, Mohamed R.
Nafady, Alaa M.
Allam, Ahmed E.
Abdel-Rahman, Iman A. M.
Almatroudi, Ahmad
Alrumaihi, Faris
Allemailem, Khaled S.
Assaf, Hamdy K.
author_sort Abdelkarem, Fahd M.
collection PubMed
description Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using (13)C-NMR will be used. Overall, 75 compounds are categorized into five major groups: gorgost-5-ene, 5,6-epoxygorgostane, 5,6-dihydroxygorgostane, 9,11-secogorgostane, and 23-demethylgorgostane, in addition to miscellaneous gorgostane. The structural diversity, selectivity for marine organisms, and biological effects of gorgostane steroids have generated considerable interest in the field of drug discovery research.
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spelling pubmed-88781452022-02-26 Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their (13)C-NMR Spectroscopic Data Characteristics Abdelkarem, Fahd M. Abouelela, Mohamed E. Kamel, Mohamed R. Nafady, Alaa M. Allam, Ahmed E. Abdel-Rahman, Iman A. M. Almatroudi, Ahmad Alrumaihi, Faris Allemailem, Khaled S. Assaf, Hamdy K. Mar Drugs Review Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using (13)C-NMR will be used. Overall, 75 compounds are categorized into five major groups: gorgost-5-ene, 5,6-epoxygorgostane, 5,6-dihydroxygorgostane, 9,11-secogorgostane, and 23-demethylgorgostane, in addition to miscellaneous gorgostane. The structural diversity, selectivity for marine organisms, and biological effects of gorgostane steroids have generated considerable interest in the field of drug discovery research. MDPI 2022-02-14 /pmc/articles/PMC8878145/ /pubmed/35200668 http://dx.doi.org/10.3390/md20020139 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abdelkarem, Fahd M.
Abouelela, Mohamed E.
Kamel, Mohamed R.
Nafady, Alaa M.
Allam, Ahmed E.
Abdel-Rahman, Iman A. M.
Almatroudi, Ahmad
Alrumaihi, Faris
Allemailem, Khaled S.
Assaf, Hamdy K.
Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their (13)C-NMR Spectroscopic Data Characteristics
title Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their (13)C-NMR Spectroscopic Data Characteristics
title_full Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their (13)C-NMR Spectroscopic Data Characteristics
title_fullStr Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their (13)C-NMR Spectroscopic Data Characteristics
title_full_unstemmed Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their (13)C-NMR Spectroscopic Data Characteristics
title_short Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their (13)C-NMR Spectroscopic Data Characteristics
title_sort chemical review of gorgostane-type steroids isolated from marine organisms and their (13)c-nmr spectroscopic data characteristics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878145/
https://www.ncbi.nlm.nih.gov/pubmed/35200668
http://dx.doi.org/10.3390/md20020139
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