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Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers
During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided two shots of CoronaVac to healthcare workers. Whereas ChAdOx1 nCoV-19 is the promising vaccine as the booster dose, the data on immunogenicity when administered after CoronaVac have been limited. The pur...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878194/ https://www.ncbi.nlm.nih.gov/pubmed/35214675 http://dx.doi.org/10.3390/vaccines10020217 |
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author | Prasithsirikul, Wisit Pongpirul, Krit Nopsopon, Tanawin Phutrakool, Phanupong Pongpirul, Wannarat Samuthpongtorn, Chatpol Suwanwattana, Pawita Jongkaewwattana, Anan |
author_facet | Prasithsirikul, Wisit Pongpirul, Krit Nopsopon, Tanawin Phutrakool, Phanupong Pongpirul, Wannarat Samuthpongtorn, Chatpol Suwanwattana, Pawita Jongkaewwattana, Anan |
author_sort | Prasithsirikul, Wisit |
collection | PubMed |
description | During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided two shots of CoronaVac to healthcare workers. Whereas ChAdOx1 nCoV-19 is the promising vaccine as the booster dose, the data on immunogenicity when administered after CoronaVac have been limited. The purpose of this study was to evaluate the immunogenicity of ChAdOx1 nCoV-19 as the third dose vaccine in healthcare workers who previously received two shots of CoronaVac. The blood samples were obtained before the third vaccination dose, and one month and three months after vaccination. All participants were measured for humoral immunity including anti-spike IgG and neutralizing antibody by ELISA. Twenty participants were stratified by random samples based on baseline IgG status for a cellular immunity function test at three-month post-vaccination, which included T cell and B cell functions by ELISpot. This study showed significant improvement for both humoral and cellular immunity one month after vaccination. Subgroup analysis indicated a significantly higher neutralizing antibody improvement for the population with a negative anti-spike IgG at baseline. Our study suggests that, while immunity level declines at three months post-vaccination, the level was sufficiently high to protect against SARS-CoV-2. |
format | Online Article Text |
id | pubmed-8878194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88781942022-02-26 Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers Prasithsirikul, Wisit Pongpirul, Krit Nopsopon, Tanawin Phutrakool, Phanupong Pongpirul, Wannarat Samuthpongtorn, Chatpol Suwanwattana, Pawita Jongkaewwattana, Anan Vaccines (Basel) Article During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided two shots of CoronaVac to healthcare workers. Whereas ChAdOx1 nCoV-19 is the promising vaccine as the booster dose, the data on immunogenicity when administered after CoronaVac have been limited. The purpose of this study was to evaluate the immunogenicity of ChAdOx1 nCoV-19 as the third dose vaccine in healthcare workers who previously received two shots of CoronaVac. The blood samples were obtained before the third vaccination dose, and one month and three months after vaccination. All participants were measured for humoral immunity including anti-spike IgG and neutralizing antibody by ELISA. Twenty participants were stratified by random samples based on baseline IgG status for a cellular immunity function test at three-month post-vaccination, which included T cell and B cell functions by ELISpot. This study showed significant improvement for both humoral and cellular immunity one month after vaccination. Subgroup analysis indicated a significantly higher neutralizing antibody improvement for the population with a negative anti-spike IgG at baseline. Our study suggests that, while immunity level declines at three months post-vaccination, the level was sufficiently high to protect against SARS-CoV-2. MDPI 2022-01-30 /pmc/articles/PMC8878194/ /pubmed/35214675 http://dx.doi.org/10.3390/vaccines10020217 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Prasithsirikul, Wisit Pongpirul, Krit Nopsopon, Tanawin Phutrakool, Phanupong Pongpirul, Wannarat Samuthpongtorn, Chatpol Suwanwattana, Pawita Jongkaewwattana, Anan Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers |
title | Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers |
title_full | Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers |
title_fullStr | Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers |
title_full_unstemmed | Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers |
title_short | Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers |
title_sort | immunogenicity of chadox1 ncov-19 booster vaccination following two coronavac shots in healthcare workers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878194/ https://www.ncbi.nlm.nih.gov/pubmed/35214675 http://dx.doi.org/10.3390/vaccines10020217 |
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