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Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers

During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided two shots of CoronaVac to healthcare workers. Whereas ChAdOx1 nCoV-19 is the promising vaccine as the booster dose, the data on immunogenicity when administered after CoronaVac have been limited. The pur...

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Autores principales: Prasithsirikul, Wisit, Pongpirul, Krit, Nopsopon, Tanawin, Phutrakool, Phanupong, Pongpirul, Wannarat, Samuthpongtorn, Chatpol, Suwanwattana, Pawita, Jongkaewwattana, Anan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878194/
https://www.ncbi.nlm.nih.gov/pubmed/35214675
http://dx.doi.org/10.3390/vaccines10020217
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author Prasithsirikul, Wisit
Pongpirul, Krit
Nopsopon, Tanawin
Phutrakool, Phanupong
Pongpirul, Wannarat
Samuthpongtorn, Chatpol
Suwanwattana, Pawita
Jongkaewwattana, Anan
author_facet Prasithsirikul, Wisit
Pongpirul, Krit
Nopsopon, Tanawin
Phutrakool, Phanupong
Pongpirul, Wannarat
Samuthpongtorn, Chatpol
Suwanwattana, Pawita
Jongkaewwattana, Anan
author_sort Prasithsirikul, Wisit
collection PubMed
description During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided two shots of CoronaVac to healthcare workers. Whereas ChAdOx1 nCoV-19 is the promising vaccine as the booster dose, the data on immunogenicity when administered after CoronaVac have been limited. The purpose of this study was to evaluate the immunogenicity of ChAdOx1 nCoV-19 as the third dose vaccine in healthcare workers who previously received two shots of CoronaVac. The blood samples were obtained before the third vaccination dose, and one month and three months after vaccination. All participants were measured for humoral immunity including anti-spike IgG and neutralizing antibody by ELISA. Twenty participants were stratified by random samples based on baseline IgG status for a cellular immunity function test at three-month post-vaccination, which included T cell and B cell functions by ELISpot. This study showed significant improvement for both humoral and cellular immunity one month after vaccination. Subgroup analysis indicated a significantly higher neutralizing antibody improvement for the population with a negative anti-spike IgG at baseline. Our study suggests that, while immunity level declines at three months post-vaccination, the level was sufficiently high to protect against SARS-CoV-2.
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spelling pubmed-88781942022-02-26 Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers Prasithsirikul, Wisit Pongpirul, Krit Nopsopon, Tanawin Phutrakool, Phanupong Pongpirul, Wannarat Samuthpongtorn, Chatpol Suwanwattana, Pawita Jongkaewwattana, Anan Vaccines (Basel) Article During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided two shots of CoronaVac to healthcare workers. Whereas ChAdOx1 nCoV-19 is the promising vaccine as the booster dose, the data on immunogenicity when administered after CoronaVac have been limited. The purpose of this study was to evaluate the immunogenicity of ChAdOx1 nCoV-19 as the third dose vaccine in healthcare workers who previously received two shots of CoronaVac. The blood samples were obtained before the third vaccination dose, and one month and three months after vaccination. All participants were measured for humoral immunity including anti-spike IgG and neutralizing antibody by ELISA. Twenty participants were stratified by random samples based on baseline IgG status for a cellular immunity function test at three-month post-vaccination, which included T cell and B cell functions by ELISpot. This study showed significant improvement for both humoral and cellular immunity one month after vaccination. Subgroup analysis indicated a significantly higher neutralizing antibody improvement for the population with a negative anti-spike IgG at baseline. Our study suggests that, while immunity level declines at three months post-vaccination, the level was sufficiently high to protect against SARS-CoV-2. MDPI 2022-01-30 /pmc/articles/PMC8878194/ /pubmed/35214675 http://dx.doi.org/10.3390/vaccines10020217 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Prasithsirikul, Wisit
Pongpirul, Krit
Nopsopon, Tanawin
Phutrakool, Phanupong
Pongpirul, Wannarat
Samuthpongtorn, Chatpol
Suwanwattana, Pawita
Jongkaewwattana, Anan
Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers
title Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers
title_full Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers
title_fullStr Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers
title_full_unstemmed Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers
title_short Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare Workers
title_sort immunogenicity of chadox1 ncov-19 booster vaccination following two coronavac shots in healthcare workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878194/
https://www.ncbi.nlm.nih.gov/pubmed/35214675
http://dx.doi.org/10.3390/vaccines10020217
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