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Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity

In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as F...

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Autores principales: Oliveira, Verônica da Silva, da Cruz, Meriângela Miranda, Bezerra, Gabriela Suassuna, Silva, Natan Emanuell Sobral e, Nogueira, Fernando Henrique Andrade, Chaves, Guilherme Maranhão, Sobrinho, José Lamartine Soares, Mendonça-Junior, Francisco Jaime Bezerra, Damasceno, Bolívar Ponciano Goulart de Lima, Converti, Attilio, de Lima, Ádley Antonini Neves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878255/
https://www.ncbi.nlm.nih.gov/pubmed/35200633
http://dx.doi.org/10.3390/md20020103
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author Oliveira, Verônica da Silva
da Cruz, Meriângela Miranda
Bezerra, Gabriela Suassuna
Silva, Natan Emanuell Sobral e
Nogueira, Fernando Henrique Andrade
Chaves, Guilherme Maranhão
Sobrinho, José Lamartine Soares
Mendonça-Junior, Francisco Jaime Bezerra
Damasceno, Bolívar Ponciano Goulart de Lima
Converti, Attilio
de Lima, Ádley Antonini Neves
author_facet Oliveira, Verônica da Silva
da Cruz, Meriângela Miranda
Bezerra, Gabriela Suassuna
Silva, Natan Emanuell Sobral e
Nogueira, Fernando Henrique Andrade
Chaves, Guilherme Maranhão
Sobrinho, José Lamartine Soares
Mendonça-Junior, Francisco Jaime Bezerra
Damasceno, Bolívar Ponciano Goulart de Lima
Converti, Attilio
de Lima, Ádley Antonini Neves
author_sort Oliveira, Verônica da Silva
collection PubMed
description In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electronic microscopy (SEM). Additionally, the antifungal potential of the films was evaluated in vitro against three species of Candida (C. albicans, C. tropicalis, and C. parapsilosis). The results of the FTIR and thermal analysis showed the incorporation of 6CN in the polymer matrix. In the diffractogram, the 6CN-chitosan films exhibited diffraction halos that were characteristic of amorphous structures, while the micrographs showed that 6CN particles were dispersed in the chitosan matrix, exhibiting pores and cracks on the film surface. In addition, the results of antifungal investigation demonstrated that 6CN-chitosan films were effective against Candida species showing potential for application as a new antifungal drug.
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spelling pubmed-88782552022-02-26 Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity Oliveira, Verônica da Silva da Cruz, Meriângela Miranda Bezerra, Gabriela Suassuna Silva, Natan Emanuell Sobral e Nogueira, Fernando Henrique Andrade Chaves, Guilherme Maranhão Sobrinho, José Lamartine Soares Mendonça-Junior, Francisco Jaime Bezerra Damasceno, Bolívar Ponciano Goulart de Lima Converti, Attilio de Lima, Ádley Antonini Neves Mar Drugs Article In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electronic microscopy (SEM). Additionally, the antifungal potential of the films was evaluated in vitro against three species of Candida (C. albicans, C. tropicalis, and C. parapsilosis). The results of the FTIR and thermal analysis showed the incorporation of 6CN in the polymer matrix. In the diffractogram, the 6CN-chitosan films exhibited diffraction halos that were characteristic of amorphous structures, while the micrographs showed that 6CN particles were dispersed in the chitosan matrix, exhibiting pores and cracks on the film surface. In addition, the results of antifungal investigation demonstrated that 6CN-chitosan films were effective against Candida species showing potential for application as a new antifungal drug. MDPI 2022-01-26 /pmc/articles/PMC8878255/ /pubmed/35200633 http://dx.doi.org/10.3390/md20020103 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oliveira, Verônica da Silva
da Cruz, Meriângela Miranda
Bezerra, Gabriela Suassuna
Silva, Natan Emanuell Sobral e
Nogueira, Fernando Henrique Andrade
Chaves, Guilherme Maranhão
Sobrinho, José Lamartine Soares
Mendonça-Junior, Francisco Jaime Bezerra
Damasceno, Bolívar Ponciano Goulart de Lima
Converti, Attilio
de Lima, Ádley Antonini Neves
Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity
title Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity
title_full Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity
title_fullStr Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity
title_full_unstemmed Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity
title_short Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity
title_sort chitosan-based films with 2-aminothiophene derivative: formulation, characterization and potential antifungal activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878255/
https://www.ncbi.nlm.nih.gov/pubmed/35200633
http://dx.doi.org/10.3390/md20020103
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