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Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity
In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as F...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878255/ https://www.ncbi.nlm.nih.gov/pubmed/35200633 http://dx.doi.org/10.3390/md20020103 |
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author | Oliveira, Verônica da Silva da Cruz, Meriângela Miranda Bezerra, Gabriela Suassuna Silva, Natan Emanuell Sobral e Nogueira, Fernando Henrique Andrade Chaves, Guilherme Maranhão Sobrinho, José Lamartine Soares Mendonça-Junior, Francisco Jaime Bezerra Damasceno, Bolívar Ponciano Goulart de Lima Converti, Attilio de Lima, Ádley Antonini Neves |
author_facet | Oliveira, Verônica da Silva da Cruz, Meriângela Miranda Bezerra, Gabriela Suassuna Silva, Natan Emanuell Sobral e Nogueira, Fernando Henrique Andrade Chaves, Guilherme Maranhão Sobrinho, José Lamartine Soares Mendonça-Junior, Francisco Jaime Bezerra Damasceno, Bolívar Ponciano Goulart de Lima Converti, Attilio de Lima, Ádley Antonini Neves |
author_sort | Oliveira, Verônica da Silva |
collection | PubMed |
description | In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electronic microscopy (SEM). Additionally, the antifungal potential of the films was evaluated in vitro against three species of Candida (C. albicans, C. tropicalis, and C. parapsilosis). The results of the FTIR and thermal analysis showed the incorporation of 6CN in the polymer matrix. In the diffractogram, the 6CN-chitosan films exhibited diffraction halos that were characteristic of amorphous structures, while the micrographs showed that 6CN particles were dispersed in the chitosan matrix, exhibiting pores and cracks on the film surface. In addition, the results of antifungal investigation demonstrated that 6CN-chitosan films were effective against Candida species showing potential for application as a new antifungal drug. |
format | Online Article Text |
id | pubmed-8878255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88782552022-02-26 Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity Oliveira, Verônica da Silva da Cruz, Meriângela Miranda Bezerra, Gabriela Suassuna Silva, Natan Emanuell Sobral e Nogueira, Fernando Henrique Andrade Chaves, Guilherme Maranhão Sobrinho, José Lamartine Soares Mendonça-Junior, Francisco Jaime Bezerra Damasceno, Bolívar Ponciano Goulart de Lima Converti, Attilio de Lima, Ádley Antonini Neves Mar Drugs Article In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electronic microscopy (SEM). Additionally, the antifungal potential of the films was evaluated in vitro against three species of Candida (C. albicans, C. tropicalis, and C. parapsilosis). The results of the FTIR and thermal analysis showed the incorporation of 6CN in the polymer matrix. In the diffractogram, the 6CN-chitosan films exhibited diffraction halos that were characteristic of amorphous structures, while the micrographs showed that 6CN particles were dispersed in the chitosan matrix, exhibiting pores and cracks on the film surface. In addition, the results of antifungal investigation demonstrated that 6CN-chitosan films were effective against Candida species showing potential for application as a new antifungal drug. MDPI 2022-01-26 /pmc/articles/PMC8878255/ /pubmed/35200633 http://dx.doi.org/10.3390/md20020103 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Oliveira, Verônica da Silva da Cruz, Meriângela Miranda Bezerra, Gabriela Suassuna Silva, Natan Emanuell Sobral e Nogueira, Fernando Henrique Andrade Chaves, Guilherme Maranhão Sobrinho, José Lamartine Soares Mendonça-Junior, Francisco Jaime Bezerra Damasceno, Bolívar Ponciano Goulart de Lima Converti, Attilio de Lima, Ádley Antonini Neves Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity |
title | Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity |
title_full | Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity |
title_fullStr | Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity |
title_full_unstemmed | Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity |
title_short | Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity |
title_sort | chitosan-based films with 2-aminothiophene derivative: formulation, characterization and potential antifungal activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878255/ https://www.ncbi.nlm.nih.gov/pubmed/35200633 http://dx.doi.org/10.3390/md20020103 |
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