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Zika Virus Immunoglobulin G Seroprevalence among Young Adults Living with HIV or without HIV in Thailand from 1997 to 2017

Zika virus (ZIKV) epidemiological data in Thailand are limited. We assessed ZIKV IgG seroprevalence among young adults during 1997–2017 and determined factors associated with ZIKV IgG seropositivity. This retrospective laboratory study included randomly selected subjects aged 18–25 years participati...

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Autores principales: Choyrum, Sirinath, Wangsaeng, Nantawan, Nechba, Anouar, Salvadori, Nicolas, Saisom, Rumpaiphorn, Achalapong, Jullapong, Putiyanun, Chaiwat, Sabsanong, Prapan, Sangsawang, Suraphan, Patamasingh Na Ayudhaya, Orada, Jourdain, Gonzague, Ngo-Giang-Huong, Nicole, Khamduang, Woottichai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878279/
https://www.ncbi.nlm.nih.gov/pubmed/35215960
http://dx.doi.org/10.3390/v14020368
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author Choyrum, Sirinath
Wangsaeng, Nantawan
Nechba, Anouar
Salvadori, Nicolas
Saisom, Rumpaiphorn
Achalapong, Jullapong
Putiyanun, Chaiwat
Sabsanong, Prapan
Sangsawang, Suraphan
Patamasingh Na Ayudhaya, Orada
Jourdain, Gonzague
Ngo-Giang-Huong, Nicole
Khamduang, Woottichai
author_facet Choyrum, Sirinath
Wangsaeng, Nantawan
Nechba, Anouar
Salvadori, Nicolas
Saisom, Rumpaiphorn
Achalapong, Jullapong
Putiyanun, Chaiwat
Sabsanong, Prapan
Sangsawang, Suraphan
Patamasingh Na Ayudhaya, Orada
Jourdain, Gonzague
Ngo-Giang-Huong, Nicole
Khamduang, Woottichai
author_sort Choyrum, Sirinath
collection PubMed
description Zika virus (ZIKV) epidemiological data in Thailand are limited. We assessed ZIKV IgG seroprevalence among young adults during 1997–2017 and determined factors associated with ZIKV IgG seropositivity. This retrospective laboratory study included randomly selected subjects aged 18–25 years participating in large clinical studies conducted in Thailand during 1997–2017. Stored plasma samples were analyzed for ZIKV IgG using an ELISA test (Anti-Zika Virus IgG, EUROIMMUN, Lübeck, Germany). Sociodemographic, clinical and laboratory data were used in univariable and multivariable analyses to identify factors associated with ZIKV IgG positivity. Of the 1648 subjects included, 1259 were pregnant women, 844 were living with HIV and 111 were living with HBV. ZIKV IgG seroprevalence was similar among the HIV-infected and -uninfected pregnant women (22.8% vs. 25.8%, p-value = 0.335) and was overall stable among the pregnant women, with a 25.2% prevalence. Factors independently associated with ZIKV IgG positivity included an age of 23–25 years as compared to 18–20 years, an HIV RNA load below 3.88 log(10) copies/mL and birth in regions outside northern Thailand. Our study shows that a large proportion of the population in Thailand probably remains susceptible to ZIKV infection, which could be the ground for future outbreaks. Continued surveillance of ZIKV spread in Thailand is needed to inform public health policies.
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spelling pubmed-88782792022-02-26 Zika Virus Immunoglobulin G Seroprevalence among Young Adults Living with HIV or without HIV in Thailand from 1997 to 2017 Choyrum, Sirinath Wangsaeng, Nantawan Nechba, Anouar Salvadori, Nicolas Saisom, Rumpaiphorn Achalapong, Jullapong Putiyanun, Chaiwat Sabsanong, Prapan Sangsawang, Suraphan Patamasingh Na Ayudhaya, Orada Jourdain, Gonzague Ngo-Giang-Huong, Nicole Khamduang, Woottichai Viruses Article Zika virus (ZIKV) epidemiological data in Thailand are limited. We assessed ZIKV IgG seroprevalence among young adults during 1997–2017 and determined factors associated with ZIKV IgG seropositivity. This retrospective laboratory study included randomly selected subjects aged 18–25 years participating in large clinical studies conducted in Thailand during 1997–2017. Stored plasma samples were analyzed for ZIKV IgG using an ELISA test (Anti-Zika Virus IgG, EUROIMMUN, Lübeck, Germany). Sociodemographic, clinical and laboratory data were used in univariable and multivariable analyses to identify factors associated with ZIKV IgG positivity. Of the 1648 subjects included, 1259 were pregnant women, 844 were living with HIV and 111 were living with HBV. ZIKV IgG seroprevalence was similar among the HIV-infected and -uninfected pregnant women (22.8% vs. 25.8%, p-value = 0.335) and was overall stable among the pregnant women, with a 25.2% prevalence. Factors independently associated with ZIKV IgG positivity included an age of 23–25 years as compared to 18–20 years, an HIV RNA load below 3.88 log(10) copies/mL and birth in regions outside northern Thailand. Our study shows that a large proportion of the population in Thailand probably remains susceptible to ZIKV infection, which could be the ground for future outbreaks. Continued surveillance of ZIKV spread in Thailand is needed to inform public health policies. MDPI 2022-02-10 /pmc/articles/PMC8878279/ /pubmed/35215960 http://dx.doi.org/10.3390/v14020368 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choyrum, Sirinath
Wangsaeng, Nantawan
Nechba, Anouar
Salvadori, Nicolas
Saisom, Rumpaiphorn
Achalapong, Jullapong
Putiyanun, Chaiwat
Sabsanong, Prapan
Sangsawang, Suraphan
Patamasingh Na Ayudhaya, Orada
Jourdain, Gonzague
Ngo-Giang-Huong, Nicole
Khamduang, Woottichai
Zika Virus Immunoglobulin G Seroprevalence among Young Adults Living with HIV or without HIV in Thailand from 1997 to 2017
title Zika Virus Immunoglobulin G Seroprevalence among Young Adults Living with HIV or without HIV in Thailand from 1997 to 2017
title_full Zika Virus Immunoglobulin G Seroprevalence among Young Adults Living with HIV or without HIV in Thailand from 1997 to 2017
title_fullStr Zika Virus Immunoglobulin G Seroprevalence among Young Adults Living with HIV or without HIV in Thailand from 1997 to 2017
title_full_unstemmed Zika Virus Immunoglobulin G Seroprevalence among Young Adults Living with HIV or without HIV in Thailand from 1997 to 2017
title_short Zika Virus Immunoglobulin G Seroprevalence among Young Adults Living with HIV or without HIV in Thailand from 1997 to 2017
title_sort zika virus immunoglobulin g seroprevalence among young adults living with hiv or without hiv in thailand from 1997 to 2017
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878279/
https://www.ncbi.nlm.nih.gov/pubmed/35215960
http://dx.doi.org/10.3390/v14020368
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