Cargando…

Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review

Background: Acromegaly is a chronic disease caused by an abnormal secretion of growth hormone (GH) by a pituitary adenoma, resulting in an increased circulating concentration of insulin-like growth factor 1 (IGF-1). The main characteristics are a slow progression of signs and symptoms, with multisys...

Descripción completa

Detalles Bibliográficos
Autores principales: De Stefani, Alberto, Dassie, Francesca, Wennberg, Alexandra, Preo, Giorgia, Muneratto, Alice, Fabris, Roberto, Maffei, Pietro, Gracco, Antonio, Bruno, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878286/
https://www.ncbi.nlm.nih.gov/pubmed/35207363
http://dx.doi.org/10.3390/jcm11041092
_version_ 1784658625291091968
author De Stefani, Alberto
Dassie, Francesca
Wennberg, Alexandra
Preo, Giorgia
Muneratto, Alice
Fabris, Roberto
Maffei, Pietro
Gracco, Antonio
Bruno, Giovanni
author_facet De Stefani, Alberto
Dassie, Francesca
Wennberg, Alexandra
Preo, Giorgia
Muneratto, Alice
Fabris, Roberto
Maffei, Pietro
Gracco, Antonio
Bruno, Giovanni
author_sort De Stefani, Alberto
collection PubMed
description Background: Acromegaly is a chronic disease caused by an abnormal secretion of growth hormone (GH) by a pituitary adenoma, resulting in an increased circulating concentration of insulin-like growth factor 1 (IGF-1). The main characteristics are a slow progression of signs and symptoms, with multisystemic involvement, leading to acral overgrowth, progressive somatic changes, and a complex range of comorbidities. Most of these comorbidities can be controlled with treatment. The literature reveals that the most evident and early signs are those related to soft tissue thickening and skeletal growth, especially in the head and neck region. Methods: The authors reviewed the available literature on the clinical oro-dental features of acromegaly, selecting articles from PubMed and Google Scholar. The aim of this review was to summarize all the reported clinical oro-dental features of acromegalic patients. Results: The most common facial dimorphisms involved the maxillo-facial district, with hypertrophy of the paranasal sinuses, thickening of the frontal bones, and protruding glabella, which may be associated with joint pain and clicks. Regarding the oro-dental signs, the most frequent are dental diastema (40–43%), mandibular overgrowth (22–24%), mandibular prognathism (20–22%), and macroglossia (54–58%). These signs of acromegaly can be significantly reduced with adequate treatment, which is more effective when initiated early. Conclusions: Increased awareness of acromegaly among dentists and maxillo-facial surgeons, along with the early identification of oro-facial changes, could lead to an earlier diagnosis and treatment, thereby improving patients’ quality of life and prognosis.
format Online
Article
Text
id pubmed-8878286
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88782862022-02-26 Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review De Stefani, Alberto Dassie, Francesca Wennberg, Alexandra Preo, Giorgia Muneratto, Alice Fabris, Roberto Maffei, Pietro Gracco, Antonio Bruno, Giovanni J Clin Med Review Background: Acromegaly is a chronic disease caused by an abnormal secretion of growth hormone (GH) by a pituitary adenoma, resulting in an increased circulating concentration of insulin-like growth factor 1 (IGF-1). The main characteristics are a slow progression of signs and symptoms, with multisystemic involvement, leading to acral overgrowth, progressive somatic changes, and a complex range of comorbidities. Most of these comorbidities can be controlled with treatment. The literature reveals that the most evident and early signs are those related to soft tissue thickening and skeletal growth, especially in the head and neck region. Methods: The authors reviewed the available literature on the clinical oro-dental features of acromegaly, selecting articles from PubMed and Google Scholar. The aim of this review was to summarize all the reported clinical oro-dental features of acromegalic patients. Results: The most common facial dimorphisms involved the maxillo-facial district, with hypertrophy of the paranasal sinuses, thickening of the frontal bones, and protruding glabella, which may be associated with joint pain and clicks. Regarding the oro-dental signs, the most frequent are dental diastema (40–43%), mandibular overgrowth (22–24%), mandibular prognathism (20–22%), and macroglossia (54–58%). These signs of acromegaly can be significantly reduced with adequate treatment, which is more effective when initiated early. Conclusions: Increased awareness of acromegaly among dentists and maxillo-facial surgeons, along with the early identification of oro-facial changes, could lead to an earlier diagnosis and treatment, thereby improving patients’ quality of life and prognosis. MDPI 2022-02-18 /pmc/articles/PMC8878286/ /pubmed/35207363 http://dx.doi.org/10.3390/jcm11041092 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
De Stefani, Alberto
Dassie, Francesca
Wennberg, Alexandra
Preo, Giorgia
Muneratto, Alice
Fabris, Roberto
Maffei, Pietro
Gracco, Antonio
Bruno, Giovanni
Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review
title Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review
title_full Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review
title_fullStr Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review
title_full_unstemmed Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review
title_short Oral Manifestations and Maxillo-Facial Features in the Acromegalic Patient: A Literature Review
title_sort oral manifestations and maxillo-facial features in the acromegalic patient: a literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878286/
https://www.ncbi.nlm.nih.gov/pubmed/35207363
http://dx.doi.org/10.3390/jcm11041092
work_keys_str_mv AT destefanialberto oralmanifestationsandmaxillofacialfeaturesintheacromegalicpatientaliteraturereview
AT dassiefrancesca oralmanifestationsandmaxillofacialfeaturesintheacromegalicpatientaliteraturereview
AT wennbergalexandra oralmanifestationsandmaxillofacialfeaturesintheacromegalicpatientaliteraturereview
AT preogiorgia oralmanifestationsandmaxillofacialfeaturesintheacromegalicpatientaliteraturereview
AT munerattoalice oralmanifestationsandmaxillofacialfeaturesintheacromegalicpatientaliteraturereview
AT fabrisroberto oralmanifestationsandmaxillofacialfeaturesintheacromegalicpatientaliteraturereview
AT maffeipietro oralmanifestationsandmaxillofacialfeaturesintheacromegalicpatientaliteraturereview
AT graccoantonio oralmanifestationsandmaxillofacialfeaturesintheacromegalicpatientaliteraturereview
AT brunogiovanni oralmanifestationsandmaxillofacialfeaturesintheacromegalicpatientaliteraturereview