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Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients

Lipids modified by oxidative stress are key players in atherosclerosis progression. Superimposed thrombosis with subsequent closure of the coronary artery leads to the clinical manifestation of acute coronary syndrome (ACS). While several studies focusing on alterations in lipid metabolism in the ac...

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Autores principales: Kosek, Vít, Hajšl, Martin, Bechyňská, Kamila, Kučerka, Ondřej, Suttnar, Jiří, Hlaváčková, Alžběta, Hajšlová, Jana, Malý, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878326/
https://www.ncbi.nlm.nih.gov/pubmed/35208199
http://dx.doi.org/10.3390/metabo12020124
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author Kosek, Vít
Hajšl, Martin
Bechyňská, Kamila
Kučerka, Ondřej
Suttnar, Jiří
Hlaváčková, Alžběta
Hajšlová, Jana
Malý, Martin
author_facet Kosek, Vít
Hajšl, Martin
Bechyňská, Kamila
Kučerka, Ondřej
Suttnar, Jiří
Hlaváčková, Alžběta
Hajšlová, Jana
Malý, Martin
author_sort Kosek, Vít
collection PubMed
description Lipids modified by oxidative stress are key players in atherosclerosis progression. Superimposed thrombosis with subsequent closure of the coronary artery leads to the clinical manifestation of acute coronary syndrome (ACS). While several studies focusing on alterations in lipid metabolism in the acute phase have been conducted, no information is available on patients’ lipidome alterations over longer time periods. In the current follow-up study, we analyzed plasma samples obtained from 17 patients three years after their ACS event (group AC). Originally, these patients were sampled 3–5 days after an index event (group B). Lipidome stability over time was studied by untargeted lipidomics using high performance liquid chromatography coupled to high resolution mass spectrometry (UHPLC–HRMS). Multi-dimensional statistics used for data processing indicated that plasmalogen lipids were the most prominent lipids separating the above patient groups and that they increased in the follow-up AC group. A similar trend was observed for lysophosphatidylethanolamine (LPE) and phosphatidylethanolamine (PE). The opposite trend was observed for two fatty acyls of hydroxy fatty acid (FAHFAs) lipids and free stearic acid. In addition, a decrease in the “classic” oxitadive stress marker, malondialdehyde (MDA), occurred during the follow-up period. Our findings present unique information about long-term lipidome changes in patients after ACS.
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spelling pubmed-88783262022-02-26 Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients Kosek, Vít Hajšl, Martin Bechyňská, Kamila Kučerka, Ondřej Suttnar, Jiří Hlaváčková, Alžběta Hajšlová, Jana Malý, Martin Metabolites Article Lipids modified by oxidative stress are key players in atherosclerosis progression. Superimposed thrombosis with subsequent closure of the coronary artery leads to the clinical manifestation of acute coronary syndrome (ACS). While several studies focusing on alterations in lipid metabolism in the acute phase have been conducted, no information is available on patients’ lipidome alterations over longer time periods. In the current follow-up study, we analyzed plasma samples obtained from 17 patients three years after their ACS event (group AC). Originally, these patients were sampled 3–5 days after an index event (group B). Lipidome stability over time was studied by untargeted lipidomics using high performance liquid chromatography coupled to high resolution mass spectrometry (UHPLC–HRMS). Multi-dimensional statistics used for data processing indicated that plasmalogen lipids were the most prominent lipids separating the above patient groups and that they increased in the follow-up AC group. A similar trend was observed for lysophosphatidylethanolamine (LPE) and phosphatidylethanolamine (PE). The opposite trend was observed for two fatty acyls of hydroxy fatty acid (FAHFAs) lipids and free stearic acid. In addition, a decrease in the “classic” oxitadive stress marker, malondialdehyde (MDA), occurred during the follow-up period. Our findings present unique information about long-term lipidome changes in patients after ACS. MDPI 2022-01-27 /pmc/articles/PMC8878326/ /pubmed/35208199 http://dx.doi.org/10.3390/metabo12020124 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kosek, Vít
Hajšl, Martin
Bechyňská, Kamila
Kučerka, Ondřej
Suttnar, Jiří
Hlaváčková, Alžběta
Hajšlová, Jana
Malý, Martin
Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients
title Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients
title_full Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients
title_fullStr Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients
title_full_unstemmed Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients
title_short Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients
title_sort long-term effects on the lipidome of acute coronary syndrome patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878326/
https://www.ncbi.nlm.nih.gov/pubmed/35208199
http://dx.doi.org/10.3390/metabo12020124
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