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From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis

Background and objective: Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia resulting from impaired secretion or action of insulin. The high levels of glucose in the blood can negatively affect the healing processes through alterations in vascularization,...

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Autores principales: Dioguardi, Mario, Cantore, Stefania, Scacco, Salvatore, Quarta, Cristian, Sovereto, Diego, Spirito, Francesca, Alovisi, Mario, Troiano, Giuseppe, Aiuto, Riccardo, Garcovich, Daniele, Crincoli, Vito, Laino, Luigi, Covelli, Michele, Malcangi, Annarita, Lo Muzio, Lorenzo, Ballini, Andrea, Di Cosola, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878354/
https://www.ncbi.nlm.nih.gov/pubmed/35207724
http://dx.doi.org/10.3390/jpm12020235
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author Dioguardi, Mario
Cantore, Stefania
Scacco, Salvatore
Quarta, Cristian
Sovereto, Diego
Spirito, Francesca
Alovisi, Mario
Troiano, Giuseppe
Aiuto, Riccardo
Garcovich, Daniele
Crincoli, Vito
Laino, Luigi
Covelli, Michele
Malcangi, Annarita
Lo Muzio, Lorenzo
Ballini, Andrea
Di Cosola, Michele
author_facet Dioguardi, Mario
Cantore, Stefania
Scacco, Salvatore
Quarta, Cristian
Sovereto, Diego
Spirito, Francesca
Alovisi, Mario
Troiano, Giuseppe
Aiuto, Riccardo
Garcovich, Daniele
Crincoli, Vito
Laino, Luigi
Covelli, Michele
Malcangi, Annarita
Lo Muzio, Lorenzo
Ballini, Andrea
Di Cosola, Michele
author_sort Dioguardi, Mario
collection PubMed
description Background and objective: Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia resulting from impaired secretion or action of insulin. The high levels of glucose in the blood can negatively affect the healing processes through alterations in vascularization, bone remodeling, and with increased susceptibility to infections. Diabetes mellitus is therefore a risk factor not only for many systemic diseases, but also for localized problems such as peri-implantitis. The objective of this systematic review was to identify a clear relationship between peri-implant inflammation indices and glycemic levels, through the investigation of prospective studies that report data on a short-term follow-up period. Our hypothesis was that peri-implant inflammatory indices may already present themselves in a statistically significant way as altered in patients with DM compared to patients without DM. Materials and methods: This review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Results: More than 992 records were identified in the PubMed, Scopus, and Cochrane Central Register of Controlled Trial electronic databases and only seven studies were included in the meta-analysis. The results of the meta-analysis report worse outcomes in patients with DM, even in the short period of six months, for peri-implatitis inflammation indices, such as Marginal bone loss (standardized (Std). mean difference (MD) 12\6 months 0.81 [0.45, 1.17]\1.82 [0.53, 3.10]), Bleeding on probing (Std. MD 12\6 months 2.84 [1.34, 4.34]\3.44 [1.41, 5.50]), Probing depth (Std. MD 12\6 months 1.14 [0.60, 1.68]\2.24 [0.66, 3.83]), and the plaque index (Std. MD 12 months 2.83 [0.09, 5.57]). Conclusion: The literature linking glycaemic control to peri-implant disease is highly heterogeneous due to lack of consistency of the definition of peri-implantitis and its clinical indicators among studies. Therefore, interpretation of finding and relevance to clinical practice should be considered on individual bases. In the era of personalized medicine, the clinician should utilize individualized information from translational researches and analyze all risk factors to provide the patient with evidence-based treatment options.
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spelling pubmed-88783542022-02-26 From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis Dioguardi, Mario Cantore, Stefania Scacco, Salvatore Quarta, Cristian Sovereto, Diego Spirito, Francesca Alovisi, Mario Troiano, Giuseppe Aiuto, Riccardo Garcovich, Daniele Crincoli, Vito Laino, Luigi Covelli, Michele Malcangi, Annarita Lo Muzio, Lorenzo Ballini, Andrea Di Cosola, Michele J Pers Med Review Background and objective: Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia resulting from impaired secretion or action of insulin. The high levels of glucose in the blood can negatively affect the healing processes through alterations in vascularization, bone remodeling, and with increased susceptibility to infections. Diabetes mellitus is therefore a risk factor not only for many systemic diseases, but also for localized problems such as peri-implantitis. The objective of this systematic review was to identify a clear relationship between peri-implant inflammation indices and glycemic levels, through the investigation of prospective studies that report data on a short-term follow-up period. Our hypothesis was that peri-implant inflammatory indices may already present themselves in a statistically significant way as altered in patients with DM compared to patients without DM. Materials and methods: This review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Results: More than 992 records were identified in the PubMed, Scopus, and Cochrane Central Register of Controlled Trial electronic databases and only seven studies were included in the meta-analysis. The results of the meta-analysis report worse outcomes in patients with DM, even in the short period of six months, for peri-implatitis inflammation indices, such as Marginal bone loss (standardized (Std). mean difference (MD) 12\6 months 0.81 [0.45, 1.17]\1.82 [0.53, 3.10]), Bleeding on probing (Std. MD 12\6 months 2.84 [1.34, 4.34]\3.44 [1.41, 5.50]), Probing depth (Std. MD 12\6 months 1.14 [0.60, 1.68]\2.24 [0.66, 3.83]), and the plaque index (Std. MD 12 months 2.83 [0.09, 5.57]). Conclusion: The literature linking glycaemic control to peri-implant disease is highly heterogeneous due to lack of consistency of the definition of peri-implantitis and its clinical indicators among studies. Therefore, interpretation of finding and relevance to clinical practice should be considered on individual bases. In the era of personalized medicine, the clinician should utilize individualized information from translational researches and analyze all risk factors to provide the patient with evidence-based treatment options. MDPI 2022-02-08 /pmc/articles/PMC8878354/ /pubmed/35207724 http://dx.doi.org/10.3390/jpm12020235 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dioguardi, Mario
Cantore, Stefania
Scacco, Salvatore
Quarta, Cristian
Sovereto, Diego
Spirito, Francesca
Alovisi, Mario
Troiano, Giuseppe
Aiuto, Riccardo
Garcovich, Daniele
Crincoli, Vito
Laino, Luigi
Covelli, Michele
Malcangi, Annarita
Lo Muzio, Lorenzo
Ballini, Andrea
Di Cosola, Michele
From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis
title From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis
title_full From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis
title_fullStr From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis
title_full_unstemmed From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis
title_short From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis
title_sort from bench to bedside in precision medicine: diabetes mellitus and peri-implantitis clinical indices with a short-term follow-up: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878354/
https://www.ncbi.nlm.nih.gov/pubmed/35207724
http://dx.doi.org/10.3390/jpm12020235
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