Four Faces of Cell-Surface HLA Class-I: Their Antigenic and Immunogenic Divergence Generating Novel Targets for Vaccines

Leukocyte cell-surface HLA-I molecules, involved in antigen presentation of peptides to CD8+ T-cells, consist of a heavy chain (HC) non-covalently linked to β2-microglobulin (β2m) (Face-1). The HC amino acid composition varies across all six isoforms of HLA-I, while that of β2m remains the same. Eac...

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Detalles Bibliográficos
Autores principales: Ravindranath, Mepur H., Ravindranath, Narendranath M., Selvan, Senthamil R., Filippone, Edward J., Amato-Menker, Carly J., El Hilali, Fatiha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878457/
https://www.ncbi.nlm.nih.gov/pubmed/35214796
http://dx.doi.org/10.3390/vaccines10020339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878457/
https://www.ncbi.nlm.nih.gov/pubmed/35214796
http://dx.doi.org/10.3390/vaccines10020339

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