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Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential

A series of novel cannabinoid-type derivatives were synthesized by the coupling of (1S,4R)-(+) and (1R,4S)-(−)-fenchones with various resorcinols/phenols. The fenchone-resorcinol derivatives were fluorinated using Selectfluor and demethylated using sodium ethanethiolate in dimethylformamide (DMF). T...

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Detalles Bibliográficos
Autores principales:	Smoum, Reem, Haj, Christeene, Hirsch, Shira, Nemirovski, Alina, Yekhtin, Zhannah, Bogoslavsky, Benny, Bakshi, Gaganjyot Kaur, Chourasia, Mukesh, Gallily, Ruth, Tam, Joseph, Mechoulam, Raphael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878464/ https://www.ncbi.nlm.nih.gov/pubmed/35209170 http://dx.doi.org/10.3390/molecules27041382

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