Cargando…

Adaptive Cellular Immunity against African Swine Fever Virus Infections

African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as w...

Descripción completa

Detalles Bibliográficos
Autores principales: Schäfer, Alexander, Franzoni, Giulia, Netherton, Christopher L., Hartmann, Luise, Blome, Sandra, Blohm, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878497/
https://www.ncbi.nlm.nih.gov/pubmed/35215216
http://dx.doi.org/10.3390/pathogens11020274
Descripción
Sumario:African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as well. The complex responses remain not well understood, and, consequently, there is no commercially available vaccine. Here, we review the current knowledge about the induction of antiviral T cell responses by cells of the myeloid lineage, as well as T cell responses in infected animals, recent efforts in vaccine research, and T cell epitopes present in ASFV.