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Adaptive Cellular Immunity against African Swine Fever Virus Infections

African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as w...

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Autores principales: Schäfer, Alexander, Franzoni, Giulia, Netherton, Christopher L., Hartmann, Luise, Blome, Sandra, Blohm, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878497/
https://www.ncbi.nlm.nih.gov/pubmed/35215216
http://dx.doi.org/10.3390/pathogens11020274
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author Schäfer, Alexander
Franzoni, Giulia
Netherton, Christopher L.
Hartmann, Luise
Blome, Sandra
Blohm, Ulrike
author_facet Schäfer, Alexander
Franzoni, Giulia
Netherton, Christopher L.
Hartmann, Luise
Blome, Sandra
Blohm, Ulrike
author_sort Schäfer, Alexander
collection PubMed
description African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as well. The complex responses remain not well understood, and, consequently, there is no commercially available vaccine. Here, we review the current knowledge about the induction of antiviral T cell responses by cells of the myeloid lineage, as well as T cell responses in infected animals, recent efforts in vaccine research, and T cell epitopes present in ASFV.
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spelling pubmed-88784972022-02-26 Adaptive Cellular Immunity against African Swine Fever Virus Infections Schäfer, Alexander Franzoni, Giulia Netherton, Christopher L. Hartmann, Luise Blome, Sandra Blohm, Ulrike Pathogens Review African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as well. The complex responses remain not well understood, and, consequently, there is no commercially available vaccine. Here, we review the current knowledge about the induction of antiviral T cell responses by cells of the myeloid lineage, as well as T cell responses in infected animals, recent efforts in vaccine research, and T cell epitopes present in ASFV. MDPI 2022-02-20 /pmc/articles/PMC8878497/ /pubmed/35215216 http://dx.doi.org/10.3390/pathogens11020274 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schäfer, Alexander
Franzoni, Giulia
Netherton, Christopher L.
Hartmann, Luise
Blome, Sandra
Blohm, Ulrike
Adaptive Cellular Immunity against African Swine Fever Virus Infections
title Adaptive Cellular Immunity against African Swine Fever Virus Infections
title_full Adaptive Cellular Immunity against African Swine Fever Virus Infections
title_fullStr Adaptive Cellular Immunity against African Swine Fever Virus Infections
title_full_unstemmed Adaptive Cellular Immunity against African Swine Fever Virus Infections
title_short Adaptive Cellular Immunity against African Swine Fever Virus Infections
title_sort adaptive cellular immunity against african swine fever virus infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878497/
https://www.ncbi.nlm.nih.gov/pubmed/35215216
http://dx.doi.org/10.3390/pathogens11020274
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