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Adaptive Cellular Immunity against African Swine Fever Virus Infections
African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878497/ https://www.ncbi.nlm.nih.gov/pubmed/35215216 http://dx.doi.org/10.3390/pathogens11020274 |
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author | Schäfer, Alexander Franzoni, Giulia Netherton, Christopher L. Hartmann, Luise Blome, Sandra Blohm, Ulrike |
author_facet | Schäfer, Alexander Franzoni, Giulia Netherton, Christopher L. Hartmann, Luise Blome, Sandra Blohm, Ulrike |
author_sort | Schäfer, Alexander |
collection | PubMed |
description | African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as well. The complex responses remain not well understood, and, consequently, there is no commercially available vaccine. Here, we review the current knowledge about the induction of antiviral T cell responses by cells of the myeloid lineage, as well as T cell responses in infected animals, recent efforts in vaccine research, and T cell epitopes present in ASFV. |
format | Online Article Text |
id | pubmed-8878497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88784972022-02-26 Adaptive Cellular Immunity against African Swine Fever Virus Infections Schäfer, Alexander Franzoni, Giulia Netherton, Christopher L. Hartmann, Luise Blome, Sandra Blohm, Ulrike Pathogens Review African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as well. The complex responses remain not well understood, and, consequently, there is no commercially available vaccine. Here, we review the current knowledge about the induction of antiviral T cell responses by cells of the myeloid lineage, as well as T cell responses in infected animals, recent efforts in vaccine research, and T cell epitopes present in ASFV. MDPI 2022-02-20 /pmc/articles/PMC8878497/ /pubmed/35215216 http://dx.doi.org/10.3390/pathogens11020274 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schäfer, Alexander Franzoni, Giulia Netherton, Christopher L. Hartmann, Luise Blome, Sandra Blohm, Ulrike Adaptive Cellular Immunity against African Swine Fever Virus Infections |
title | Adaptive Cellular Immunity against African Swine Fever Virus Infections |
title_full | Adaptive Cellular Immunity against African Swine Fever Virus Infections |
title_fullStr | Adaptive Cellular Immunity against African Swine Fever Virus Infections |
title_full_unstemmed | Adaptive Cellular Immunity against African Swine Fever Virus Infections |
title_short | Adaptive Cellular Immunity against African Swine Fever Virus Infections |
title_sort | adaptive cellular immunity against african swine fever virus infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878497/ https://www.ncbi.nlm.nih.gov/pubmed/35215216 http://dx.doi.org/10.3390/pathogens11020274 |
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