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Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties
Neurological diseases represent one of the main causes of disability in human life. Consequently, investigating new strategies capable of improving the quality of life in neurological patients is necessary. For decades, researchers have been working to improve the efficacy and safety of mesenchymal...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878691/ https://www.ncbi.nlm.nih.gov/pubmed/35216215 http://dx.doi.org/10.3390/ijms23042088 |
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author | Schepici, Giovanni Gugliandolo, Agnese Mazzon, Emanuela |
author_facet | Schepici, Giovanni Gugliandolo, Agnese Mazzon, Emanuela |
author_sort | Schepici, Giovanni |
collection | PubMed |
description | Neurological diseases represent one of the main causes of disability in human life. Consequently, investigating new strategies capable of improving the quality of life in neurological patients is necessary. For decades, researchers have been working to improve the efficacy and safety of mesenchymal stromal cells (MSCs) therapy based on MSCs’ regenerative and immunomodulatory properties and multilinear differentiation potential. Therefore, strategies such as MSCs preconditioning are useful to improve their application to restore damaged neuronal circuits following neurological insults. This review is focused on preconditioning MSCs therapy as a potential application to major neurological diseases. The aim of our work is to summarize both the in vitro and in vivo studies that demonstrate the efficacy of MSC preconditioning on neuronal regeneration and cell survival as a possible application to neurological damage. |
format | Online Article Text |
id | pubmed-8878691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88786912022-02-26 Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties Schepici, Giovanni Gugliandolo, Agnese Mazzon, Emanuela Int J Mol Sci Review Neurological diseases represent one of the main causes of disability in human life. Consequently, investigating new strategies capable of improving the quality of life in neurological patients is necessary. For decades, researchers have been working to improve the efficacy and safety of mesenchymal stromal cells (MSCs) therapy based on MSCs’ regenerative and immunomodulatory properties and multilinear differentiation potential. Therefore, strategies such as MSCs preconditioning are useful to improve their application to restore damaged neuronal circuits following neurological insults. This review is focused on preconditioning MSCs therapy as a potential application to major neurological diseases. The aim of our work is to summarize both the in vitro and in vivo studies that demonstrate the efficacy of MSC preconditioning on neuronal regeneration and cell survival as a possible application to neurological damage. MDPI 2022-02-14 /pmc/articles/PMC8878691/ /pubmed/35216215 http://dx.doi.org/10.3390/ijms23042088 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schepici, Giovanni Gugliandolo, Agnese Mazzon, Emanuela Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties |
title | Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties |
title_full | Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties |
title_fullStr | Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties |
title_full_unstemmed | Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties |
title_short | Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties |
title_sort | mesenchymal stromal cells preconditioning: a new strategy to improve neuroprotective properties |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878691/ https://www.ncbi.nlm.nih.gov/pubmed/35216215 http://dx.doi.org/10.3390/ijms23042088 |
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