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Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties

Neurological diseases represent one of the main causes of disability in human life. Consequently, investigating new strategies capable of improving the quality of life in neurological patients is necessary. For decades, researchers have been working to improve the efficacy and safety of mesenchymal...

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Detalles Bibliográficos
Autores principales: Schepici, Giovanni, Gugliandolo, Agnese, Mazzon, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878691/
https://www.ncbi.nlm.nih.gov/pubmed/35216215
http://dx.doi.org/10.3390/ijms23042088
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author Schepici, Giovanni
Gugliandolo, Agnese
Mazzon, Emanuela
author_facet Schepici, Giovanni
Gugliandolo, Agnese
Mazzon, Emanuela
author_sort Schepici, Giovanni
collection PubMed
description Neurological diseases represent one of the main causes of disability in human life. Consequently, investigating new strategies capable of improving the quality of life in neurological patients is necessary. For decades, researchers have been working to improve the efficacy and safety of mesenchymal stromal cells (MSCs) therapy based on MSCs’ regenerative and immunomodulatory properties and multilinear differentiation potential. Therefore, strategies such as MSCs preconditioning are useful to improve their application to restore damaged neuronal circuits following neurological insults. This review is focused on preconditioning MSCs therapy as a potential application to major neurological diseases. The aim of our work is to summarize both the in vitro and in vivo studies that demonstrate the efficacy of MSC preconditioning on neuronal regeneration and cell survival as a possible application to neurological damage.
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spelling pubmed-88786912022-02-26 Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties Schepici, Giovanni Gugliandolo, Agnese Mazzon, Emanuela Int J Mol Sci Review Neurological diseases represent one of the main causes of disability in human life. Consequently, investigating new strategies capable of improving the quality of life in neurological patients is necessary. For decades, researchers have been working to improve the efficacy and safety of mesenchymal stromal cells (MSCs) therapy based on MSCs’ regenerative and immunomodulatory properties and multilinear differentiation potential. Therefore, strategies such as MSCs preconditioning are useful to improve their application to restore damaged neuronal circuits following neurological insults. This review is focused on preconditioning MSCs therapy as a potential application to major neurological diseases. The aim of our work is to summarize both the in vitro and in vivo studies that demonstrate the efficacy of MSC preconditioning on neuronal regeneration and cell survival as a possible application to neurological damage. MDPI 2022-02-14 /pmc/articles/PMC8878691/ /pubmed/35216215 http://dx.doi.org/10.3390/ijms23042088 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schepici, Giovanni
Gugliandolo, Agnese
Mazzon, Emanuela
Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties
title Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties
title_full Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties
title_fullStr Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties
title_full_unstemmed Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties
title_short Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties
title_sort mesenchymal stromal cells preconditioning: a new strategy to improve neuroprotective properties
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878691/
https://www.ncbi.nlm.nih.gov/pubmed/35216215
http://dx.doi.org/10.3390/ijms23042088
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