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Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue—A Scoping Review

Background: pleural mesothelioma is a rare cancer in the general population, but it is more common in subjects occupationally exposed to asbestos. Studies with asbestos fiber quantification in pleural tissue are scarce: for this reason, we aimed at undertaking a scoping review to summarize the evide...

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Autores principales: Caraballo-Arias, Yohama, Caffaro, Paola, Boffetta, Paolo, Violante, Francesco Saverio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878760/
https://www.ncbi.nlm.nih.gov/pubmed/35207583
http://dx.doi.org/10.3390/life12020296
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author Caraballo-Arias, Yohama
Caffaro, Paola
Boffetta, Paolo
Violante, Francesco Saverio
author_facet Caraballo-Arias, Yohama
Caffaro, Paola
Boffetta, Paolo
Violante, Francesco Saverio
author_sort Caraballo-Arias, Yohama
collection PubMed
description Background: pleural mesothelioma is a rare cancer in the general population, but it is more common in subjects occupationally exposed to asbestos. Studies with asbestos fiber quantification in pleural tissue are scarce: for this reason, we aimed at undertaking a scoping review to summarize the evidence provided by studies in which asbestos fibers were determined by electron microscopy (SEM or TEM) in human pleural tissues, whether normal or pathologic. Materials and methods: A scoping review of articles that quantified asbestos fibers in human pleural tissue (normal or pathologic) by electron microscopy (SEM or TEM), in subjects with asbestos exposure (if any) was performed. Results: The 12 studies selected comprised 137 cases, out of which 142 samples were analyzed. Asbestos fibers were detected in 111 samples (78%) and were below the detectable limit in 31 samples (22%). The concentration of asbestos fibers detected in the positive samples was distributed from as low as 0.01 mfgdt (millions of fibers per gram of dry tissue) up to 240 mfgdt. However, the minimum concentration of fibers overlaps in the three types of tissues (normal pleura, pleural plaque, mesothelioma) in terms of magnitude; therefore, it is not possible to distinguish a definite pattern which differentiates one tissue from the other. Conclusions: The studies included were heterogeneous as to the representativeness of the samples and analytical techniques; the possibility of false negatives must be considered. It would be desirable to systematically search for asbestos fibers to fill the knowledge gap about the presence of asbestos fibers in normal or pathological pleural tissue in order to better understand the development of the different pleural diseases induced by this mineral.
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spelling pubmed-88787602022-02-26 Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue—A Scoping Review Caraballo-Arias, Yohama Caffaro, Paola Boffetta, Paolo Violante, Francesco Saverio Life (Basel) Review Background: pleural mesothelioma is a rare cancer in the general population, but it is more common in subjects occupationally exposed to asbestos. Studies with asbestos fiber quantification in pleural tissue are scarce: for this reason, we aimed at undertaking a scoping review to summarize the evidence provided by studies in which asbestos fibers were determined by electron microscopy (SEM or TEM) in human pleural tissues, whether normal or pathologic. Materials and methods: A scoping review of articles that quantified asbestos fibers in human pleural tissue (normal or pathologic) by electron microscopy (SEM or TEM), in subjects with asbestos exposure (if any) was performed. Results: The 12 studies selected comprised 137 cases, out of which 142 samples were analyzed. Asbestos fibers were detected in 111 samples (78%) and were below the detectable limit in 31 samples (22%). The concentration of asbestos fibers detected in the positive samples was distributed from as low as 0.01 mfgdt (millions of fibers per gram of dry tissue) up to 240 mfgdt. However, the minimum concentration of fibers overlaps in the three types of tissues (normal pleura, pleural plaque, mesothelioma) in terms of magnitude; therefore, it is not possible to distinguish a definite pattern which differentiates one tissue from the other. Conclusions: The studies included were heterogeneous as to the representativeness of the samples and analytical techniques; the possibility of false negatives must be considered. It would be desirable to systematically search for asbestos fibers to fill the knowledge gap about the presence of asbestos fibers in normal or pathological pleural tissue in order to better understand the development of the different pleural diseases induced by this mineral. MDPI 2022-02-16 /pmc/articles/PMC8878760/ /pubmed/35207583 http://dx.doi.org/10.3390/life12020296 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Caraballo-Arias, Yohama
Caffaro, Paola
Boffetta, Paolo
Violante, Francesco Saverio
Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue—A Scoping Review
title Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue—A Scoping Review
title_full Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue—A Scoping Review
title_fullStr Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue—A Scoping Review
title_full_unstemmed Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue—A Scoping Review
title_short Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue—A Scoping Review
title_sort quantitative assessment of asbestos fibers in normal and pathological pleural tissue—a scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878760/
https://www.ncbi.nlm.nih.gov/pubmed/35207583
http://dx.doi.org/10.3390/life12020296
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