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In-Hospital and Long-Term Outcomes in Patients with Head and Neck Cancer Bleeding
Background and Objectives: The purpose of the present study was to elucidate the in-hospital and long-term outcomes of patients with head and neck cancer (HNC) bleeding and to analyze the risk factors for mortality. Materials and Methods: We included patients who presented to the emergency departmen...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878826/ https://www.ncbi.nlm.nih.gov/pubmed/35208501 http://dx.doi.org/10.3390/medicina58020177 |
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author | Yen, Chieh-Ching Ho, Che-Fang Wu, Chia-Chien Tsao, Yu-Ning Chaou, Chung-Hsien Chen, Shou-Yen Ng, Chip-Jin Yeh, Heng |
author_facet | Yen, Chieh-Ching Ho, Che-Fang Wu, Chia-Chien Tsao, Yu-Ning Chaou, Chung-Hsien Chen, Shou-Yen Ng, Chip-Jin Yeh, Heng |
author_sort | Yen, Chieh-Ching |
collection | PubMed |
description | Background and Objectives: The purpose of the present study was to elucidate the in-hospital and long-term outcomes of patients with head and neck cancer (HNC) bleeding and to analyze the risk factors for mortality. Materials and Methods: We included patients who presented to the emergency department (ED) with HNC bleeding. Variables of patients who survived and died were compared and associated factors were investigated by logistic regression and Cox’s proportional hazard model. Results: A total of 125 patients were enrolled in the present study. Fifty-nine (52.8%) patients experienced a recurrent bleeding event. The in-hospital mortality rate was 16%. The overall survival at 1, 3 and 5 years was 48%, 41% and 34%, respectively. The median survival time was 9.2 months. Multivariate logistic regression analyses revealed that risk factors for in-hospital mortality were inotropic support (OR = 10.41; Cl 1.81–59.84; p = 0.009), hypopharyngeal cancer (OR = 4.32; Cl 1.29–14.46; p = 0.018), and M stage (OR = 5.90; Cl 1.07–32.70; p = 0.042). Multivariate Cox regression analyses indicate that heart rate >110 (beats/min) (HR = 2.02; Cl 1.16–3.51; p = 0.013), inotropic support (HR = 3.25; Cl 1.20–8.82; p = 0.021), and hypopharygneal cancer (HR = 2.22; Cl 1.21–4.06; p = 0.010) were all significant independent predictors of poorer overall survival. Conclusions: HNC bleeding commonly represents the advanced disease stage. Recognition of associated factors aids in the risk stratification of patients with HNC bleeding. |
format | Online Article Text |
id | pubmed-8878826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88788262022-02-26 In-Hospital and Long-Term Outcomes in Patients with Head and Neck Cancer Bleeding Yen, Chieh-Ching Ho, Che-Fang Wu, Chia-Chien Tsao, Yu-Ning Chaou, Chung-Hsien Chen, Shou-Yen Ng, Chip-Jin Yeh, Heng Medicina (Kaunas) Article Background and Objectives: The purpose of the present study was to elucidate the in-hospital and long-term outcomes of patients with head and neck cancer (HNC) bleeding and to analyze the risk factors for mortality. Materials and Methods: We included patients who presented to the emergency department (ED) with HNC bleeding. Variables of patients who survived and died were compared and associated factors were investigated by logistic regression and Cox’s proportional hazard model. Results: A total of 125 patients were enrolled in the present study. Fifty-nine (52.8%) patients experienced a recurrent bleeding event. The in-hospital mortality rate was 16%. The overall survival at 1, 3 and 5 years was 48%, 41% and 34%, respectively. The median survival time was 9.2 months. Multivariate logistic regression analyses revealed that risk factors for in-hospital mortality were inotropic support (OR = 10.41; Cl 1.81–59.84; p = 0.009), hypopharyngeal cancer (OR = 4.32; Cl 1.29–14.46; p = 0.018), and M stage (OR = 5.90; Cl 1.07–32.70; p = 0.042). Multivariate Cox regression analyses indicate that heart rate >110 (beats/min) (HR = 2.02; Cl 1.16–3.51; p = 0.013), inotropic support (HR = 3.25; Cl 1.20–8.82; p = 0.021), and hypopharygneal cancer (HR = 2.22; Cl 1.21–4.06; p = 0.010) were all significant independent predictors of poorer overall survival. Conclusions: HNC bleeding commonly represents the advanced disease stage. Recognition of associated factors aids in the risk stratification of patients with HNC bleeding. MDPI 2022-01-25 /pmc/articles/PMC8878826/ /pubmed/35208501 http://dx.doi.org/10.3390/medicina58020177 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yen, Chieh-Ching Ho, Che-Fang Wu, Chia-Chien Tsao, Yu-Ning Chaou, Chung-Hsien Chen, Shou-Yen Ng, Chip-Jin Yeh, Heng In-Hospital and Long-Term Outcomes in Patients with Head and Neck Cancer Bleeding |
title | In-Hospital and Long-Term Outcomes in Patients with Head and Neck Cancer Bleeding |
title_full | In-Hospital and Long-Term Outcomes in Patients with Head and Neck Cancer Bleeding |
title_fullStr | In-Hospital and Long-Term Outcomes in Patients with Head and Neck Cancer Bleeding |
title_full_unstemmed | In-Hospital and Long-Term Outcomes in Patients with Head and Neck Cancer Bleeding |
title_short | In-Hospital and Long-Term Outcomes in Patients with Head and Neck Cancer Bleeding |
title_sort | in-hospital and long-term outcomes in patients with head and neck cancer bleeding |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878826/ https://www.ncbi.nlm.nih.gov/pubmed/35208501 http://dx.doi.org/10.3390/medicina58020177 |
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