Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel Na(V)1.5

The cardiac sodium ion channel (Na(V)1.5) is a protein with four domains (DI-DIV), each with six transmembrane segments. Its opening and subsequent inactivation results in the brief rapid influx of Na(+) ions resulting in the depolarization of cardiomyocytes. The neurotoxin veratridine (VTD) inhibit...

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Detalles Bibliográficos
Autores principales: Gulsevin, Alican, Glazer, Andrew M., Shields, Tiffany, Kroncke, Brett M., Roden, Dan M., Meiler, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878851/
https://www.ncbi.nlm.nih.gov/pubmed/35216338
http://dx.doi.org/10.3390/ijms23042225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878851/
https://www.ncbi.nlm.nih.gov/pubmed/35216338
http://dx.doi.org/10.3390/ijms23042225

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