Cargando…

Effect of Cholesterol Molecules on Aβ1-42 Wild-Type and Mutants Trimers

Alzheimer’s disease displays aggregates of the amyloid-beta (Aβ) peptide in the brain, and there is increasing evidence that cholesterol may contribute to the pathogenesis of the disease. Though many experimental and theoretical studies have focused on the interactions of Aβ oligomers with membrane...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Trung Hai, Nguyen, Phuong H., Ngo, Son Tung, Derreumaux, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879133/ https://www.ncbi.nlm.nih.gov/pubmed/35209177 http://dx.doi.org/10.3390/molecules27041395

Ejemplares similares

C-Terminal Plays as the Possible Nucleation of the Self-Aggregation of the S-Shape Aβ(11–42) Tetramer in Solution: Intensive MD Study
por: Tung, Nguyen Thanh, et al.
Publicado: (2019)

Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease
por: Nguyen, Phuong H., et al.
Publicado: (2023)

Atomistic investigation of an Iowa Amyloid-β trimer in aqueous solution
por: Ngo, Son Tung, et al.
Publicado: (2018)

Identifying Possible AChE Inhibitors from Drug-like Molecules via Machine Learning and Experimental Studies
por: Nguyen, Trung Hai, et al.
Publicado: (2022)

Adequate prediction for inhibitor affinity of Aβ(40) protofibril using the linear interaction energy method
por: Ngo, Son Tung, et al.
Publicado: (2019)

Comparison of in vitro and in vivo oligomeric states of a wild type and mutant trimeric inner membrane multidrug transporter
por: Wang, Zhaoshuai, et al.
Publicado: (2018)

Insights into the binding and covalent inhibition mechanism of PF-07321332 to SARS-CoV-2 M(pro)
por: Ngo, Son Tung, et al.
Publicado: (2022)

AFM Probing of Amyloid-Beta 42 Dimers and Trimers
por: Maity, Sibaprasad, et al.
Publicado: (2020)

Unbinding ligands from SARS-CoV-2 Mpro via umbrella sampling simulations
por: Tam, Nguyen Minh, et al.
Publicado: (2022)

Thermodynamics and kinetics in antibody resistance of the 501Y.V2 SARS-CoV-2 variant
por: Ngo, Son Tung, et al.
Publicado: (2021)

Emergence of Barrel Motif in Amyloid-β Trimer: A Computational Study
por: Nguyen, Hoang Linh, et al.
Publicado: (2020)

Evaluation of a DNA Aβ(42) Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ(42) Trimer
por: Lambracht-Washington, Doris, et al.
Publicado: (2017)

An automated clinical mass spectrometric method for identification and quantification of variant and wild‐type amyloid‐β 1‐40 and 1‐42 peptides in CSF
por: DeMarco, Mari L., et al.
Publicado: (2020)

Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer
por: Lambracht-Washington, Doris, et al.
Publicado: (2017)

Changes in the brain transcriptome after DNA Aβ42 trimer immunization in a 3xTg-AD mouse model
por: Lambracht-Washington, Doris, et al.
Publicado: (2020)

Upgrading nirmatrelvir to inhibit SARS-CoV-2 Mpro via DeepFrag and free energy calculations
por: Tam, Nguyen Minh, et al.
Publicado: (2023)

Capping of Aβ42 Oligomers by Small Molecule Inhibitors
por: Fu, Ziao, et al.
Publicado: (2014)

Searching for potential inhibitors of SARS-COV-2 main protease using supervised learning and perturbation calculations
por: Nguyen, Trung Hai, et al.
Publicado: (2023)

In vitro and in silico determination of glutaminyl cyclase inhibitors
por: Tran, Phuong-Thao, et al.
Publicado: (2019)

Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene
por: Ying, Hongyu, et al.
Publicado: (2015)

Cholesterol Pathways Affected by Small Molecules That Decrease Sterol Levels in Niemann-Pick Type C Mutant Cells
por: Rujoi, Madalina, et al.
Publicado: (2010)

Adsorption of β-galactosidase of Alicyclobacillus acidocaldarius on wild type and mutants spores of Bacillus subtilis
por: Sirec, Teja, et al.
Publicado: (2012)

The Position of Aβ(22−40) and Aβ(1−42) in Anionic Lipid Membranes Containing Cholesterol
por: Barrett, Matthew A., et al.
Publicado: (2015)

Trichoderma asperellum Chi42 Genes Encode Chitinase
por: Loc, Nguyen Hoang, et al.
Publicado: (2011)

1-Alkenyl-3-methylimidazolium trifluoromethanesulfonate ionic liquids: novel and low-viscosity ionic liquid electrolytes for dye-sensitized solar cells
por: Nguyen, Phuong Tuyet, et al.
Publicado: (2018)

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer
por: O’Connell, James, et al.
Publicado: (2019)

Etersalate prevents the formations of 6Aβ(16-22) oligomer: An in silico study
por: Ngo, Son Tung, et al.
Publicado: (2018)

Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila
por: Iijima, Koichi, et al.
Publicado: (2008)

Probing differences among Aβ oligomers with two triangular trimers derived from Aβ
por: Kreutzer, Adam G., et al.
Publicado: (2023)

Cancer: From Wild-Type to Mutant Huntingtin
por: Thion, Morgane Sonia, et al.
Publicado: (2018)

Entropy Correlation and Its Impacts on Data Aggregation in a Wireless Sensor Network
por: Nguyen Thi Thanh, Nga, et al.
Publicado: (2018)

Reply to Legat, B.; Rocher, L. The Limits of Pairwise Correlation to Model the Joint Entropy. Comment on “Nguyen Thi Thanh et al. Entropy Correlation and Its Impacts on Data Aggregation in a Wireless Sensor Network. Sensors 2018, 18, 3118”
por: Nguyen Thi Thanh, Nga, et al.
Publicado: (2021)

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
por: van den Boomen, Dick J. H., et al.
Publicado: (2020)

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model
por: Voss, James E., et al.
Publicado: (2017)

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model
por: Voss, James E., et al.
Publicado: (2018)

Trimerization and Genotype–Phenotype Correlation of COL4A5 Mutants in Alport Syndrome
por: Kamura, Misato, et al.
Publicado: (2020)

Anatomical Study of Femoral Condylar Index in Magnetic Resonance Imaging: Implication to Total Knee Replacement Surgery for Vietnamese People
por: Trung, Dung Tran, et al.
Publicado: (2019)

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
por: Pham, Minh Quan, et al.
Publicado: (2020)

Correction: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
por: Pham, Minh Quan, et al.
Publicado: (2022)

A Trimeric Lipoprotein Assists in Trimeric Autotransporter Biogenesis in Enterobacteria
por: Grin, Iwan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5sg71rco95cb6ap4oarn0aorvd