Cargando…

Associations of Metabolic and Obstetric Risk Parameters with Timing of Lactogenesis II

Lactogenesis II is the onset of copious milk production following parturition. Delayed onset of lactogenesis II (DLII) often contributes to poorer lactation performance, which may adversely affect maternal and child health. The present study aims to identify the metabolic and obstetric risk factors...

Descripción completa

Detalles Bibliográficos
Autores principales: Mullen, Amber J., O’Connor, Deborah L., Hanley, Anthony J., Piedimonte, Giovanni, Wallace, Maeve, Ley, Sylvia H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879345/
https://www.ncbi.nlm.nih.gov/pubmed/35215526
http://dx.doi.org/10.3390/nu14040876
_version_ 1784658876736471040
author Mullen, Amber J.
O’Connor, Deborah L.
Hanley, Anthony J.
Piedimonte, Giovanni
Wallace, Maeve
Ley, Sylvia H.
author_facet Mullen, Amber J.
O’Connor, Deborah L.
Hanley, Anthony J.
Piedimonte, Giovanni
Wallace, Maeve
Ley, Sylvia H.
author_sort Mullen, Amber J.
collection PubMed
description Lactogenesis II is the onset of copious milk production following parturition. Delayed onset of lactogenesis II (DLII) often contributes to poorer lactation performance, which may adversely affect maternal and child health. The present study aims to identify the metabolic and obstetric risk factors for DLII in a secondary analysis of a prospective cohort study following pregnant women through postpartum. We defined the onset of lactogenesis II as delayed if it occurred ≥72 h postpartum. Multiple logistic regression analyses were conducted to evaluate the associations of metabolic and obstetric variables with DLII. Median onset of lactogenesis II was 72.4 h (IQR 60.4–91.6) postpartum, and 55.4% (98 of 177) of women experienced DLII. Time to first breast contact ≥ 2 h postpartum compared to ≤1 h postpartum was associated with DLII (OR 2.71 95% CI 1.12–6.53) with adjustment for age, race, pregravid BMI, primiparity, and mode of delivery, while metabolic variables were not significantly associated with DLII. In this comprehensive examination of potential metabolic and obstetric parameters, earlier timing of putting the infant to the breast remained significantly associated with earlier onset of milk coming in after consideration of the other potential risk factors. Obstetrical practices, including putting the baby to the breast later, may have an important impact on the timing of lactation, and interventions are needed to address this concern.
format Online
Article
Text
id pubmed-8879345
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88793452022-02-26 Associations of Metabolic and Obstetric Risk Parameters with Timing of Lactogenesis II Mullen, Amber J. O’Connor, Deborah L. Hanley, Anthony J. Piedimonte, Giovanni Wallace, Maeve Ley, Sylvia H. Nutrients Article Lactogenesis II is the onset of copious milk production following parturition. Delayed onset of lactogenesis II (DLII) often contributes to poorer lactation performance, which may adversely affect maternal and child health. The present study aims to identify the metabolic and obstetric risk factors for DLII in a secondary analysis of a prospective cohort study following pregnant women through postpartum. We defined the onset of lactogenesis II as delayed if it occurred ≥72 h postpartum. Multiple logistic regression analyses were conducted to evaluate the associations of metabolic and obstetric variables with DLII. Median onset of lactogenesis II was 72.4 h (IQR 60.4–91.6) postpartum, and 55.4% (98 of 177) of women experienced DLII. Time to first breast contact ≥ 2 h postpartum compared to ≤1 h postpartum was associated with DLII (OR 2.71 95% CI 1.12–6.53) with adjustment for age, race, pregravid BMI, primiparity, and mode of delivery, while metabolic variables were not significantly associated with DLII. In this comprehensive examination of potential metabolic and obstetric parameters, earlier timing of putting the infant to the breast remained significantly associated with earlier onset of milk coming in after consideration of the other potential risk factors. Obstetrical practices, including putting the baby to the breast later, may have an important impact on the timing of lactation, and interventions are needed to address this concern. MDPI 2022-02-19 /pmc/articles/PMC8879345/ /pubmed/35215526 http://dx.doi.org/10.3390/nu14040876 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mullen, Amber J.
O’Connor, Deborah L.
Hanley, Anthony J.
Piedimonte, Giovanni
Wallace, Maeve
Ley, Sylvia H.
Associations of Metabolic and Obstetric Risk Parameters with Timing of Lactogenesis II
title Associations of Metabolic and Obstetric Risk Parameters with Timing of Lactogenesis II
title_full Associations of Metabolic and Obstetric Risk Parameters with Timing of Lactogenesis II
title_fullStr Associations of Metabolic and Obstetric Risk Parameters with Timing of Lactogenesis II
title_full_unstemmed Associations of Metabolic and Obstetric Risk Parameters with Timing of Lactogenesis II
title_short Associations of Metabolic and Obstetric Risk Parameters with Timing of Lactogenesis II
title_sort associations of metabolic and obstetric risk parameters with timing of lactogenesis ii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879345/
https://www.ncbi.nlm.nih.gov/pubmed/35215526
http://dx.doi.org/10.3390/nu14040876
work_keys_str_mv AT mullenamberj associationsofmetabolicandobstetricriskparameterswithtimingoflactogenesisii
AT oconnordeborahl associationsofmetabolicandobstetricriskparameterswithtimingoflactogenesisii
AT hanleyanthonyj associationsofmetabolicandobstetricriskparameterswithtimingoflactogenesisii
AT piedimontegiovanni associationsofmetabolicandobstetricriskparameterswithtimingoflactogenesisii
AT wallacemaeve associationsofmetabolicandobstetricriskparameterswithtimingoflactogenesisii
AT leysylviah associationsofmetabolicandobstetricriskparameterswithtimingoflactogenesisii