Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential

Fungi are well-known for their abundant supply of metabolites with unrivaled structure and promising bioactivities. Naphthalenones are among these fungal metabolites, that are biosynthesized through the 1,8-dihydroxy-naphthalene polyketide pathway. They revealed a wide spectrum of bioactivities, inc...

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Autores principales: Ibrahim, Sabrin R. M., Fadil, Sana A., Fadil, Haifa A., Eshmawi, Bayan A., Mohamed, Shaimaa G. A., Mohamed, Gamal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879409/
https://www.ncbi.nlm.nih.gov/pubmed/35202181
http://dx.doi.org/10.3390/toxins14020154
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author Ibrahim, Sabrin R. M.
Fadil, Sana A.
Fadil, Haifa A.
Eshmawi, Bayan A.
Mohamed, Shaimaa G. A.
Mohamed, Gamal A.
author_facet Ibrahim, Sabrin R. M.
Fadil, Sana A.
Fadil, Haifa A.
Eshmawi, Bayan A.
Mohamed, Shaimaa G. A.
Mohamed, Gamal A.
author_sort Ibrahim, Sabrin R. M.
collection PubMed
description Fungi are well-known for their abundant supply of metabolites with unrivaled structure and promising bioactivities. Naphthalenones are among these fungal metabolites, that are biosynthesized through the 1,8-dihydroxy-naphthalene polyketide pathway. They revealed a wide spectrum of bioactivities, including phytotoxic, neuro-protective, cytotoxic, antiviral, nematocidal, antimycobacterial, antimalarial, antimicrobial, and anti-inflammatory. The current review emphasizes the reported naphthalenone derivatives produced by various fungal species, including their sources, structures, biosynthesis, and bioactivities in the period from 1972 to 2021. Overall, more than 167 references with 159 metabolites are listed.
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spelling pubmed-88794092022-02-26 Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential Ibrahim, Sabrin R. M. Fadil, Sana A. Fadil, Haifa A. Eshmawi, Bayan A. Mohamed, Shaimaa G. A. Mohamed, Gamal A. Toxins (Basel) Review Fungi are well-known for their abundant supply of metabolites with unrivaled structure and promising bioactivities. Naphthalenones are among these fungal metabolites, that are biosynthesized through the 1,8-dihydroxy-naphthalene polyketide pathway. They revealed a wide spectrum of bioactivities, including phytotoxic, neuro-protective, cytotoxic, antiviral, nematocidal, antimycobacterial, antimalarial, antimicrobial, and anti-inflammatory. The current review emphasizes the reported naphthalenone derivatives produced by various fungal species, including their sources, structures, biosynthesis, and bioactivities in the period from 1972 to 2021. Overall, more than 167 references with 159 metabolites are listed. MDPI 2022-02-19 /pmc/articles/PMC8879409/ /pubmed/35202181 http://dx.doi.org/10.3390/toxins14020154 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ibrahim, Sabrin R. M.
Fadil, Sana A.
Fadil, Haifa A.
Eshmawi, Bayan A.
Mohamed, Shaimaa G. A.
Mohamed, Gamal A.
Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential
title Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential
title_full Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential
title_fullStr Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential
title_full_unstemmed Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential
title_short Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential
title_sort fungal naphthalenones; promising metabolites for drug discovery: structures, biosynthesis, sources, and pharmacological potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879409/
https://www.ncbi.nlm.nih.gov/pubmed/35202181
http://dx.doi.org/10.3390/toxins14020154
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