TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection

The core of HIV-1 viruses bearing the capsid change N74D (HIV-1-N74D) do not bind the human protein CPSF6. In primary human CD4(+) T cells, HIV-1-N74D viruses exhibit an infectivity defect when compared to wild-type. We first investigated whether loss of CPSF6 binding accounts for the loss of infect...

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Detalles Bibliográficos
Autores principales: Selyutina, Anastasia, Simons, Lacy M., Kirby, Karen A., Bulnes-Ramos, Angel, Hu, Pan, Sarafianos, Stefan G., Hultquist, Judd F., Diaz-Griffero, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879423/
https://www.ncbi.nlm.nih.gov/pubmed/35215956
http://dx.doi.org/10.3390/v14020363

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