Cargando…
Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin
(1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the “Maskne”, caused by th...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879469/ https://www.ncbi.nlm.nih.gov/pubmed/35209043 http://dx.doi.org/10.3390/molecules27041255 |
_version_ | 1784658898935873536 |
---|---|
author | Sommatis, Sabrina Capillo, Maria Chiara Maccario, Cristina Liga, Elsa Grimaldi, Giulia Rauso, Raffaele Bencini, Pier Luca Guida, Stefania Zerbinati, Nicola Mocchi, Roberto |
author_facet | Sommatis, Sabrina Capillo, Maria Chiara Maccario, Cristina Liga, Elsa Grimaldi, Giulia Rauso, Raffaele Bencini, Pier Luca Guida, Stefania Zerbinati, Nicola Mocchi, Roberto |
author_sort | Sommatis, Sabrina |
collection | PubMed |
description | (1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the “Maskne”, caused by the sebum excretion rate (SER) that stimulates microbial proliferation. (2) Methods: the present study was focused on the rheological characterization and quality assurance of the preservative system of an anti-acne serum. The biological effectiveness (cytotoxicity—skin and eye irritation—antimicrobial, biofilm eradication and anti-inflammatory activity) was evaluated in a monolayer cell line of keratinocytes (HaCaT) and on 3D models (reconstructed human epidermis, RHE and human reconstructed corneal epithelium, HCE). The Cutibacterium acnes, as the most relevant acne-inducing bacterium, is chosen as a pro-inflammatory stimulus and to evaluate the antimicrobial activity of the serum. (3) Results and Conclusions: Rheology allows to simulate serum behavior at rest, extrusion and application, so the serum could be defined as having a solid-like behavior and being pseudoplastic. The preservative system is in compliance with the criteria of the reference standard. Biological effectiveness evaluation shows non-cytotoxic and irritant behavior with a good antimicrobial and anti-inflammatory activity of the formulation, supporting the effectiveness of the serum for acne-prone skin treatment. |
format | Online Article Text |
id | pubmed-8879469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88794692022-02-26 Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin Sommatis, Sabrina Capillo, Maria Chiara Maccario, Cristina Liga, Elsa Grimaldi, Giulia Rauso, Raffaele Bencini, Pier Luca Guida, Stefania Zerbinati, Nicola Mocchi, Roberto Molecules Article (1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the “Maskne”, caused by the sebum excretion rate (SER) that stimulates microbial proliferation. (2) Methods: the present study was focused on the rheological characterization and quality assurance of the preservative system of an anti-acne serum. The biological effectiveness (cytotoxicity—skin and eye irritation—antimicrobial, biofilm eradication and anti-inflammatory activity) was evaluated in a monolayer cell line of keratinocytes (HaCaT) and on 3D models (reconstructed human epidermis, RHE and human reconstructed corneal epithelium, HCE). The Cutibacterium acnes, as the most relevant acne-inducing bacterium, is chosen as a pro-inflammatory stimulus and to evaluate the antimicrobial activity of the serum. (3) Results and Conclusions: Rheology allows to simulate serum behavior at rest, extrusion and application, so the serum could be defined as having a solid-like behavior and being pseudoplastic. The preservative system is in compliance with the criteria of the reference standard. Biological effectiveness evaluation shows non-cytotoxic and irritant behavior with a good antimicrobial and anti-inflammatory activity of the formulation, supporting the effectiveness of the serum for acne-prone skin treatment. MDPI 2022-02-13 /pmc/articles/PMC8879469/ /pubmed/35209043 http://dx.doi.org/10.3390/molecules27041255 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sommatis, Sabrina Capillo, Maria Chiara Maccario, Cristina Liga, Elsa Grimaldi, Giulia Rauso, Raffaele Bencini, Pier Luca Guida, Stefania Zerbinati, Nicola Mocchi, Roberto Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin |
title | Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin |
title_full | Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin |
title_fullStr | Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin |
title_full_unstemmed | Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin |
title_short | Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin |
title_sort | biophysical and biological tools to better characterize the stability, safety and efficacy of a cosmeceutical for acne-prone skin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879469/ https://www.ncbi.nlm.nih.gov/pubmed/35209043 http://dx.doi.org/10.3390/molecules27041255 |
work_keys_str_mv | AT sommatissabrina biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin AT capillomariachiara biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin AT maccariocristina biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin AT ligaelsa biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin AT grimaldigiulia biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin AT rausoraffaele biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin AT bencinipierluca biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin AT guidastefania biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin AT zerbinatinicola biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin AT mocchiroberto biophysicalandbiologicaltoolstobettercharacterizethestabilitysafetyandefficacyofacosmeceuticalforacneproneskin |