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Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin

(1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the “Maskne”, caused by th...

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Autores principales: Sommatis, Sabrina, Capillo, Maria Chiara, Maccario, Cristina, Liga, Elsa, Grimaldi, Giulia, Rauso, Raffaele, Bencini, Pier Luca, Guida, Stefania, Zerbinati, Nicola, Mocchi, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879469/
https://www.ncbi.nlm.nih.gov/pubmed/35209043
http://dx.doi.org/10.3390/molecules27041255
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author Sommatis, Sabrina
Capillo, Maria Chiara
Maccario, Cristina
Liga, Elsa
Grimaldi, Giulia
Rauso, Raffaele
Bencini, Pier Luca
Guida, Stefania
Zerbinati, Nicola
Mocchi, Roberto
author_facet Sommatis, Sabrina
Capillo, Maria Chiara
Maccario, Cristina
Liga, Elsa
Grimaldi, Giulia
Rauso, Raffaele
Bencini, Pier Luca
Guida, Stefania
Zerbinati, Nicola
Mocchi, Roberto
author_sort Sommatis, Sabrina
collection PubMed
description (1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the “Maskne”, caused by the sebum excretion rate (SER) that stimulates microbial proliferation. (2) Methods: the present study was focused on the rheological characterization and quality assurance of the preservative system of an anti-acne serum. The biological effectiveness (cytotoxicity—skin and eye irritation—antimicrobial, biofilm eradication and anti-inflammatory activity) was evaluated in a monolayer cell line of keratinocytes (HaCaT) and on 3D models (reconstructed human epidermis, RHE and human reconstructed corneal epithelium, HCE). The Cutibacterium acnes, as the most relevant acne-inducing bacterium, is chosen as a pro-inflammatory stimulus and to evaluate the antimicrobial activity of the serum. (3) Results and Conclusions: Rheology allows to simulate serum behavior at rest, extrusion and application, so the serum could be defined as having a solid-like behavior and being pseudoplastic. The preservative system is in compliance with the criteria of the reference standard. Biological effectiveness evaluation shows non-cytotoxic and irritant behavior with a good antimicrobial and anti-inflammatory activity of the formulation, supporting the effectiveness of the serum for acne-prone skin treatment.
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spelling pubmed-88794692022-02-26 Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin Sommatis, Sabrina Capillo, Maria Chiara Maccario, Cristina Liga, Elsa Grimaldi, Giulia Rauso, Raffaele Bencini, Pier Luca Guida, Stefania Zerbinati, Nicola Mocchi, Roberto Molecules Article (1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the “Maskne”, caused by the sebum excretion rate (SER) that stimulates microbial proliferation. (2) Methods: the present study was focused on the rheological characterization and quality assurance of the preservative system of an anti-acne serum. The biological effectiveness (cytotoxicity—skin and eye irritation—antimicrobial, biofilm eradication and anti-inflammatory activity) was evaluated in a monolayer cell line of keratinocytes (HaCaT) and on 3D models (reconstructed human epidermis, RHE and human reconstructed corneal epithelium, HCE). The Cutibacterium acnes, as the most relevant acne-inducing bacterium, is chosen as a pro-inflammatory stimulus and to evaluate the antimicrobial activity of the serum. (3) Results and Conclusions: Rheology allows to simulate serum behavior at rest, extrusion and application, so the serum could be defined as having a solid-like behavior and being pseudoplastic. The preservative system is in compliance with the criteria of the reference standard. Biological effectiveness evaluation shows non-cytotoxic and irritant behavior with a good antimicrobial and anti-inflammatory activity of the formulation, supporting the effectiveness of the serum for acne-prone skin treatment. MDPI 2022-02-13 /pmc/articles/PMC8879469/ /pubmed/35209043 http://dx.doi.org/10.3390/molecules27041255 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sommatis, Sabrina
Capillo, Maria Chiara
Maccario, Cristina
Liga, Elsa
Grimaldi, Giulia
Rauso, Raffaele
Bencini, Pier Luca
Guida, Stefania
Zerbinati, Nicola
Mocchi, Roberto
Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin
title Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin
title_full Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin
title_fullStr Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin
title_full_unstemmed Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin
title_short Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin
title_sort biophysical and biological tools to better characterize the stability, safety and efficacy of a cosmeceutical for acne-prone skin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879469/
https://www.ncbi.nlm.nih.gov/pubmed/35209043
http://dx.doi.org/10.3390/molecules27041255
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