The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity

A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related disorders; therefore, identification of the structural determinants of toxicity is of upmost im...

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Detalles Bibliográficos
Autores principales: Xu, Catherine K., Castellana-Cruz, Marta, Chen, Serene W., Du, Zhen, Meisl, Georg, Levin, Aviad, Mannini, Benedetta, Itzhaki, Laura S., Knowles, Tuomas P. J., Dobson, Christopher M., Cremades, Nunilo, Kumita, Janet R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879557/
https://www.ncbi.nlm.nih.gov/pubmed/35209093
http://dx.doi.org/10.3390/molecules27041293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879557/
https://www.ncbi.nlm.nih.gov/pubmed/35209093
http://dx.doi.org/10.3390/molecules27041293

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