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The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity

A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related disorders; therefore, identification of the structural determinants of toxicity is of upmost im...

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Detalles Bibliográficos
Autores principales:	Xu, Catherine K., Castellana-Cruz, Marta, Chen, Serene W., Du, Zhen, Meisl, Georg, Levin, Aviad, Mannini, Benedetta, Itzhaki, Laura S., Knowles, Tuomas P. J., Dobson, Christopher M., Cremades, Nunilo, Kumita, Janet R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879557/ https://www.ncbi.nlm.nih.gov/pubmed/35209093 http://dx.doi.org/10.3390/molecules27041293

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