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Post-Vaccination SARS-CoV-2 Infections among Health Workers at the University Hospital of Verona, Italy: A Retrospective Cohort Survey

Background: The SARS-CoV-2 vaccination campaign began on 27 December 2020 in Europe, primarily involving health workers. This study aimed to assess the SARS-CoV-2 vaccination effectiveness, as assessed by reductions in incidence, symptom severity, and further infection spreading. Methods: A retrospe...

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Autores principales: Porru, Stefano, Spiteri, Gianluca, Monaco, Maria Grazia Lourdes, Valotti, Alessandro, Carta, Angela, Lotti, Virginia, Diani, Erica, Lippi, Giuseppe, Gibellini, Davide, Verlato, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879605/
https://www.ncbi.nlm.nih.gov/pubmed/35214733
http://dx.doi.org/10.3390/vaccines10020272
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author Porru, Stefano
Spiteri, Gianluca
Monaco, Maria Grazia Lourdes
Valotti, Alessandro
Carta, Angela
Lotti, Virginia
Diani, Erica
Lippi, Giuseppe
Gibellini, Davide
Verlato, Giuseppe
author_facet Porru, Stefano
Spiteri, Gianluca
Monaco, Maria Grazia Lourdes
Valotti, Alessandro
Carta, Angela
Lotti, Virginia
Diani, Erica
Lippi, Giuseppe
Gibellini, Davide
Verlato, Giuseppe
author_sort Porru, Stefano
collection PubMed
description Background: The SARS-CoV-2 vaccination campaign began on 27 December 2020 in Europe, primarily involving health workers. This study aimed to assess the SARS-CoV-2 vaccination effectiveness, as assessed by reductions in incidence, symptom severity, and further infection spreading. Methods: A retrospective cohort study was conducted on 9811 health workers operating at the Verona University Hospital, Italy, from 27 December 2020 to 3 May 2021. All health workers were offered vaccination with Comirnaty (BNT162b2, BioNTech/Pfizer, Mainz, Germany/New York, United States), and a health surveillance program was implemented with periodical swab testing. Vaccination status and clinical data were collected using an ad hoc semi-structured questionnaire and health surveillance charts. Results: As of 3rd of May, 82.5% of health workers had been vaccinated against SAR-CoV-2, and 177 (1.8%) had tested positive for SARS-CoV-2. Vaccination more than halved the cumulative incidence of SARS-CoV-2 infection and reduced by two-thirds the cumulative incidence of symptomatic subjects. In detail, most unvaccinated HWs were symptomatic; 50% reported fever, 45% reported ageusia/anosmia, and nearly 20% reported dyspnea. These percentages were much lower in HWs who had been vaccinated for at least 14 days (18% for fever and anosmia, 6% for dyspnea and ageusia). Moreover, cases of vaccine breakthrough were sixfold less likely to further spread the infection than unvaccinated HWs. Conclusions: SARS-CoV-2 vaccination reduced the infection frequency among HWs, further spreading of the infection, and the presence, severity, and duration of COVID-19-related symptoms.
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spelling pubmed-88796052022-02-26 Post-Vaccination SARS-CoV-2 Infections among Health Workers at the University Hospital of Verona, Italy: A Retrospective Cohort Survey Porru, Stefano Spiteri, Gianluca Monaco, Maria Grazia Lourdes Valotti, Alessandro Carta, Angela Lotti, Virginia Diani, Erica Lippi, Giuseppe Gibellini, Davide Verlato, Giuseppe Vaccines (Basel) Article Background: The SARS-CoV-2 vaccination campaign began on 27 December 2020 in Europe, primarily involving health workers. This study aimed to assess the SARS-CoV-2 vaccination effectiveness, as assessed by reductions in incidence, symptom severity, and further infection spreading. Methods: A retrospective cohort study was conducted on 9811 health workers operating at the Verona University Hospital, Italy, from 27 December 2020 to 3 May 2021. All health workers were offered vaccination with Comirnaty (BNT162b2, BioNTech/Pfizer, Mainz, Germany/New York, United States), and a health surveillance program was implemented with periodical swab testing. Vaccination status and clinical data were collected using an ad hoc semi-structured questionnaire and health surveillance charts. Results: As of 3rd of May, 82.5% of health workers had been vaccinated against SAR-CoV-2, and 177 (1.8%) had tested positive for SARS-CoV-2. Vaccination more than halved the cumulative incidence of SARS-CoV-2 infection and reduced by two-thirds the cumulative incidence of symptomatic subjects. In detail, most unvaccinated HWs were symptomatic; 50% reported fever, 45% reported ageusia/anosmia, and nearly 20% reported dyspnea. These percentages were much lower in HWs who had been vaccinated for at least 14 days (18% for fever and anosmia, 6% for dyspnea and ageusia). Moreover, cases of vaccine breakthrough were sixfold less likely to further spread the infection than unvaccinated HWs. Conclusions: SARS-CoV-2 vaccination reduced the infection frequency among HWs, further spreading of the infection, and the presence, severity, and duration of COVID-19-related symptoms. MDPI 2022-02-10 /pmc/articles/PMC8879605/ /pubmed/35214733 http://dx.doi.org/10.3390/vaccines10020272 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Porru, Stefano
Spiteri, Gianluca
Monaco, Maria Grazia Lourdes
Valotti, Alessandro
Carta, Angela
Lotti, Virginia
Diani, Erica
Lippi, Giuseppe
Gibellini, Davide
Verlato, Giuseppe
Post-Vaccination SARS-CoV-2 Infections among Health Workers at the University Hospital of Verona, Italy: A Retrospective Cohort Survey
title Post-Vaccination SARS-CoV-2 Infections among Health Workers at the University Hospital of Verona, Italy: A Retrospective Cohort Survey
title_full Post-Vaccination SARS-CoV-2 Infections among Health Workers at the University Hospital of Verona, Italy: A Retrospective Cohort Survey
title_fullStr Post-Vaccination SARS-CoV-2 Infections among Health Workers at the University Hospital of Verona, Italy: A Retrospective Cohort Survey
title_full_unstemmed Post-Vaccination SARS-CoV-2 Infections among Health Workers at the University Hospital of Verona, Italy: A Retrospective Cohort Survey
title_short Post-Vaccination SARS-CoV-2 Infections among Health Workers at the University Hospital of Verona, Italy: A Retrospective Cohort Survey
title_sort post-vaccination sars-cov-2 infections among health workers at the university hospital of verona, italy: a retrospective cohort survey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879605/
https://www.ncbi.nlm.nih.gov/pubmed/35214733
http://dx.doi.org/10.3390/vaccines10020272
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