Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease

Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elde...

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Autor principal: Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Themed Section: Neurodegenerative Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879631/
https://www.ncbi.nlm.nih.gov/pubmed/35229998
http://dx.doi.org/10.1002/ame2.12212
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author Zheng, Jie
author_facet Zheng, Jie
author_sort Zheng, Jie
collection PubMed
description Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elderly. Pro‐neurogenic therapies including rescuing innate AHN, cell engraftment and glia‐neuron reprogramming hold great potential for compensating the neuronal loss and rewiring the degenerated neuronal network in AD, but there are still great challenges to be overcome. This review covers recent advances in unraveling the involvement of AHN in AD and highlights the prospect of emerging pro‐neurogenic remedies.
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spelling pubmed-88796312022-03-01 Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease Zheng, Jie Animal Model Exp Med Themed Section: Neurodegenerative Disease Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elderly. Pro‐neurogenic therapies including rescuing innate AHN, cell engraftment and glia‐neuron reprogramming hold great potential for compensating the neuronal loss and rewiring the degenerated neuronal network in AD, but there are still great challenges to be overcome. This review covers recent advances in unraveling the involvement of AHN in AD and highlights the prospect of emerging pro‐neurogenic remedies. John Wiley and Sons Inc. 2022-02-06 /pmc/articles/PMC8879631/ /pubmed/35229998 http://dx.doi.org/10.1002/ame2.12212 Text en © 2022 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Themed Section: Neurodegenerative Disease
Zheng, Jie
Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease
title Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease
title_full Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease
title_fullStr Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease
title_full_unstemmed Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease
title_short Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease
title_sort hippocampal neurogenesis and pro‐neurogenic therapies for alzheimer's disease
topic Themed Section: Neurodegenerative Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879631/
https://www.ncbi.nlm.nih.gov/pubmed/35229998
http://dx.doi.org/10.1002/ame2.12212
work_keys_str_mv AT zhengjie hippocampalneurogenesisandproneurogenictherapiesforalzheimersdisease

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