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HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis
Objective: To assess evidence on the efficacy of adjuvant human papillomavirus (HPV) vaccination in patients treated for HPV-related disease across different susceptible organ sites. Methods: A systematic review was conducted to identify studies addressing the efficacy of adjuvant HPV vaccination on...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879645/ https://www.ncbi.nlm.nih.gov/pubmed/35214697 http://dx.doi.org/10.3390/vaccines10020239 |
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author | Di Donato, Violante Caruso, Giuseppe Bogani, Giorgio Cavallari, Eugenio Nelson Palaia, Gaspare Perniola, Giorgia Ralli, Massimo Sorrenti, Sara Romeo, Umberto Pernazza, Angelina Pierangeli, Alessandra Clementi, Ilaria Mingoli, Andrea Cassoni, Andrea Tanzi, Federica Cuccu, Ilaria Recine, Nadia Mancino, Pasquale de Vincentiis, Marco Valentini, Valentino d’Ettorre, Gabriella Della Rocca, Carlo Mastroianni, Claudio Maria Antonelli, Guido Polimeni, Antonella Muzii, Ludovico Palaia, Innocenza |
author_facet | Di Donato, Violante Caruso, Giuseppe Bogani, Giorgio Cavallari, Eugenio Nelson Palaia, Gaspare Perniola, Giorgia Ralli, Massimo Sorrenti, Sara Romeo, Umberto Pernazza, Angelina Pierangeli, Alessandra Clementi, Ilaria Mingoli, Andrea Cassoni, Andrea Tanzi, Federica Cuccu, Ilaria Recine, Nadia Mancino, Pasquale de Vincentiis, Marco Valentini, Valentino d’Ettorre, Gabriella Della Rocca, Carlo Mastroianni, Claudio Maria Antonelli, Guido Polimeni, Antonella Muzii, Ludovico Palaia, Innocenza |
author_sort | Di Donato, Violante |
collection | PubMed |
description | Objective: To assess evidence on the efficacy of adjuvant human papillomavirus (HPV) vaccination in patients treated for HPV-related disease across different susceptible organ sites. Methods: A systematic review was conducted to identify studies addressing the efficacy of adjuvant HPV vaccination on reducing the risk of recurrence of HPV-related preinvasive diseases. Results were reported as mean differences or pooled odds ratios (OR) with 95% confidence intervals (95% CI). Results: Sixteen studies were identified for the final analysis. Overall, 21,472 patients with cervical dysplasia were included: 4132 (19.2%) received the peri-operative HPV vaccine, while 17,340 (80.8%) underwent surgical treatment alone. The recurrences of CIN 1+ (OR 0.45, 95% CI 0.27 to 0.73; p = 0.001), CIN 2+ (OR 0.33, 95% CI 0.20 to 0.52; p < 0.0001), and CIN 3 (OR 0.28, 95% CI 0.13 to 0.59; p = 0.0009) were lower in the vaccinated than in unvaccinated group. Similarly, adjuvant vaccination reduced the risk of developing anal intraepithelial neoplasia (p = 0.005) and recurrent respiratory papillomatosis (p = 0.004). No differences in anogenital warts and vulvar intraepithelial neoplasia recurrence rate were observed comparing vaccinated and unvaccinated individuals. Conclusions: Adjuvant HPV vaccination is associated with a reduced risk of CIN recurrence, although there are limited data regarding its role in other HPV-related diseases. Further research is warranted to shed more light on the role of HPV vaccination as adjuvant therapy after primary treatment. |
format | Online Article Text |
id | pubmed-8879645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88796452022-02-26 HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis Di Donato, Violante Caruso, Giuseppe Bogani, Giorgio Cavallari, Eugenio Nelson Palaia, Gaspare Perniola, Giorgia Ralli, Massimo Sorrenti, Sara Romeo, Umberto Pernazza, Angelina Pierangeli, Alessandra Clementi, Ilaria Mingoli, Andrea Cassoni, Andrea Tanzi, Federica Cuccu, Ilaria Recine, Nadia Mancino, Pasquale de Vincentiis, Marco Valentini, Valentino d’Ettorre, Gabriella Della Rocca, Carlo Mastroianni, Claudio Maria Antonelli, Guido Polimeni, Antonella Muzii, Ludovico Palaia, Innocenza Vaccines (Basel) Systematic Review Objective: To assess evidence on the efficacy of adjuvant human papillomavirus (HPV) vaccination in patients treated for HPV-related disease across different susceptible organ sites. Methods: A systematic review was conducted to identify studies addressing the efficacy of adjuvant HPV vaccination on reducing the risk of recurrence of HPV-related preinvasive diseases. Results were reported as mean differences or pooled odds ratios (OR) with 95% confidence intervals (95% CI). Results: Sixteen studies were identified for the final analysis. Overall, 21,472 patients with cervical dysplasia were included: 4132 (19.2%) received the peri-operative HPV vaccine, while 17,340 (80.8%) underwent surgical treatment alone. The recurrences of CIN 1+ (OR 0.45, 95% CI 0.27 to 0.73; p = 0.001), CIN 2+ (OR 0.33, 95% CI 0.20 to 0.52; p < 0.0001), and CIN 3 (OR 0.28, 95% CI 0.13 to 0.59; p = 0.0009) were lower in the vaccinated than in unvaccinated group. Similarly, adjuvant vaccination reduced the risk of developing anal intraepithelial neoplasia (p = 0.005) and recurrent respiratory papillomatosis (p = 0.004). No differences in anogenital warts and vulvar intraepithelial neoplasia recurrence rate were observed comparing vaccinated and unvaccinated individuals. Conclusions: Adjuvant HPV vaccination is associated with a reduced risk of CIN recurrence, although there are limited data regarding its role in other HPV-related diseases. Further research is warranted to shed more light on the role of HPV vaccination as adjuvant therapy after primary treatment. MDPI 2022-02-04 /pmc/articles/PMC8879645/ /pubmed/35214697 http://dx.doi.org/10.3390/vaccines10020239 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Di Donato, Violante Caruso, Giuseppe Bogani, Giorgio Cavallari, Eugenio Nelson Palaia, Gaspare Perniola, Giorgia Ralli, Massimo Sorrenti, Sara Romeo, Umberto Pernazza, Angelina Pierangeli, Alessandra Clementi, Ilaria Mingoli, Andrea Cassoni, Andrea Tanzi, Federica Cuccu, Ilaria Recine, Nadia Mancino, Pasquale de Vincentiis, Marco Valentini, Valentino d’Ettorre, Gabriella Della Rocca, Carlo Mastroianni, Claudio Maria Antonelli, Guido Polimeni, Antonella Muzii, Ludovico Palaia, Innocenza HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
title | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
title_full | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
title_fullStr | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
title_full_unstemmed | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
title_short | HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis |
title_sort | hpv vaccination after primary treatment of hpv-related disease across different organ sites: a multidisciplinary comprehensive review and meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879645/ https://www.ncbi.nlm.nih.gov/pubmed/35214697 http://dx.doi.org/10.3390/vaccines10020239 |
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